Structural and functional consequences of the STAT5BN642H driver mutation

Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia

(2019) Sebastian Kollmann et al.   LEUKEMIA

Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2

(2018) Constance Baer et al.   HAEMATOLOGICA

Molecular Insights Into Pathogenesis of Peripheral T Cell Lymphoma: a Review

(2018) Waseem Lone et al.   Current Hematologic Malignancy Reports

Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2

(2018) Constance Baer et al.   HAEMATOLOGICA

A functional in vitro assay for screening inhibitors of STAT5B phosphorylation

(2018) Elvin D. de Araujo et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia

(2018) Nicholas C. P. Cross et al.   LEUKEMIA

STAT5BN642H is a driver mutation for T cell neoplasia

(2017) Ha Thi Thanh Pham et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling

(2017) E I Andersson et al.   LEUKEMIA

Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome

(2017) Omer Schwartzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strategies for over-expression and purification of recombinant full length STAT5B in Escherichia coli

(2017) Elvin D. de Araujo et al.   PROTEIN EXPRESSION AND PURIFICATION

STAT3 mutation impacts biological and clinical features of T-LGL leukemia

(2017) Antonella Teramo et al.   Oncotarget

Somatic STAT5b gain-of-function mutations in early onset nonclonal eosinophilia, urticaria, dermatitis, and diarrhea

(2016) Chi A. Ma et al.   BLOOD

High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia

(2016) E. I. Andersson et al.   BLOOD

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors

(2016) V.-P. Lavallee et al.   BLOOD

CSF3R T618I, ASXL1 G942 fs and STAT5B N642H trimutation co-contribute to a rare chronic neutrophilic leukaemia manifested by rapidly progressive leucocytosis, severe infections, persistent fever and deep venous thrombosis

(2016) Qianhui Luo et al.   BRITISH JOURNAL OF HAEMATOLOGY

Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia

(2016) Cristina López et al.   BRITISH JOURNAL OF HAEMATOLOGY

Identification of Gene Mutations and Fusion Genes in Patients with Sézary Syndrome

(2016) Aparna Prasad et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma

(2016) M-L Nairismägi et al.   LEUKEMIA

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations

(2016) Annalisa Roberti et al.   Nature Communications

Prognostic significance of signal transducer and activator of transcription 5 and 5b expression in Epstein-Barr virus-positive patients with chronic lymphocytic leukemia

(2016) Panagiotis T. Diamantopoulos et al.   Cancer Medicine

Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization

(2016) Dirk Fahrenkamp et al.   Scientific Reports

Primary CNS T-cell Lymphomas

(2015) Madhu P. Menon et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma

(2015) Lu Jiang et al.   NATURE GENETICS

Tandem SUMO fusion vectors for improving soluble protein expression and purification

(2015) Fernando Guerrero et al.   PROTEIN EXPRESSION AND PURIFICATION

Rare occurrence of a STAT5B N642H mutation in adult T-cell acute lymphoblastic leukemia

(2015) Xiaolin Ma et al.   Cancer Genetics

Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

(2015) Daria V. Babushok et al.   Cancer Genetics

Concurrent Mutations in ATM and Genes Associated with Common γ Chain Signaling in Peripheral T Cell Lymphoma

(2015) Haley M. Simpson et al.   PLoS One

Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia

(2014) M. J. Kiel et al.   BLOOD

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

(2014) O. R. Bandapalli et al.   HAEMATOLOGICA

Frequent STAT5B mutations in γδ hepatosplenic T-cell lymphomas

(2014) A Nicolae et al.   LEUKEMIA

Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

(2014) M Kontro et al.   LEUKEMIA

BCR-ABL Affects STAT5A and STAT5B Differentially

(2014) Michael Schaller-Schönitz et al.   PLoS One

Bulk-solvent and overall scaling revisited: faster calculations, improved results

(2013) P. V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

(2013) H. L. M. Rajala et al.   BLOOD

Comprehensive Analysis of Transcriptome Variation Uncovers Known and Novel Driver Events in T-Cell Acute Lymphoblastic Leukemia

(2013) Zeynep Kalender Atak et al.   PLoS Genetics

Use of knowledge-based restraints inphenix.refineto improve macromolecular refinement at low resolution

(2012) Jeffrey J. Headd et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The language of SH2 domain interactions defines phosphotyrosine-mediated signal transduction

(2012) Bernard A. Liu et al.   FEBS LETTERS

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Automatic multiple-zone rigid-body refinement with a large convergence radius

(2009) Pavel V. Afonine et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

xia2: an expert system for macromolecular crystallography data reduction

(2009) G. Winter   JOURNAL OF APPLIED CRYSTALLOGRAPHY

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

(2009) Silvia Buonamici et al.   NATURE

Crystal structure of unphosphorylated STAT3 core fragment

(2008) Zhiyong Ren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B

(2008) L. Hennighausen et al.   GENES & DEVELOPMENT