Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS

Testing the Neurovascular Hypothesis of Alzheimer's Disease: LRP-1 Antisense Reduces Blood-brain Barrier Clearance, Increases Brain Levels of Amyloid-β Protein, and Impairs Cognition

(2017) Laura B. Jaeger et al.   JOURNAL OF ALZHEIMERS DISEASE

γ-Secretase inhibitors and modulators

(2013) Todd E. Golde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β

(2013) Simon J. Henderson et al.   BRAIN

Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions

(2013) Fredrik Olsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AZ-4217: A High Potency BACE Inhibitor Displaying Acute Central Efficacy in Different In Vivo Models and Reduced Amyloid Deposition in Tg2576 Mice

(2013) S. Eketjall et al.   JOURNAL OF NEUROSCIENCE

Presystemic Metabolism of AZ’0908, A Novel mPGES-1 Inhibitor: An In Vitro and In Vivo Cross-Species Comparison

(2013) Johan Bylund et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43

(2013) Masayasu Okochi et al.   Cell Reports

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

(2012) Fredrik Jeppsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Aminoimidazoles as β-Secretase (BACE-1) Inhibitors Showing Amyloid-β (Aβ) Lowering in Brain

(2012) Ylva Gravenfors et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β-Amyloid Peptides

(2012) Britt-Marie Swahn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reducing Available Soluble β-Amyloid Prevents Progression of Cerebral Amyloid Angiopathy in Transgenic Mice

(2012) Julia L. Gregory et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Alzheimer's Disease: Presenilin 2-Sparing  -Secretase Inhibition Is a Tolerable A  Peptide-Lowering Strategy

(2012) T. Borgegard et al.   JOURNAL OF NEUROSCIENCE

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

(2012) N. Sehgal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the Nogo Receptor Complex in Diseases of the Central Nervous System

(2011) C. L. McDonald et al.   CURRENT MEDICINAL CHEMISTRY

Robust Central Reduction of Amyloid-  in Humans with an Orally Available, Non-Peptidic  -Secretase Inhibitor

(2011) P. C. May et al.   JOURNAL OF NEUROSCIENCE

Sink Hypothesis and Therapeutic Strategies for Attenuating Aβ Levels

(2011) Yan Zhang et al.   NEUROSCIENTIST

Evidence for dimeric BACE-mediated APP processing

(2010) Shaobo Jin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain

(2010) Berislav V. Zlokovic et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Cell biology, regulation and inhibition of β-secretase (BACE-1)

(2009) Clare E. Hunt et al.   FEBS Journal

A  Immunotherapy: Intracerebral Sequestration of A  by an Anti-A  Monoclonal Antibody 266 with High Affinity to Soluble A 

(2009) K. Yamada et al.   JOURNAL OF NEUROSCIENCE

An amyloid-β protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

(2009) Anna Lord et al.   NEUROBIOLOGY OF DISEASE