Activation of PTEN by inhibition of TRPV4 suppresses colon cancer development

Orai1 is critical for Notch-driven aggressiveness under hypoxic conditions in triple-negative breast cancers

(2018) Xiaoyu Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway

(2018) Yu Fang et al.   BIOMEDICINE & PHARMACOTHERAPY

Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes

(2018) Aida Olivan-Viguera et al.   PLoS One

TRPV4 (Transient Receptor Potential Vanilloid 4) Mediates Endothelium-Dependent Contractions in the Aortas of Hypertensive MiceNovelty and Significance

(2017) Peng Zhang et al.   HYPERTENSION

LinkedOmics: analyzing multi-omics data within and across 32 cancer types

(2017) Suhas V Vasaikar et al.   NUCLEIC ACIDS RESEARCH

Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells

(2017) A A Peters et al.   ONCOGENE

TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway

(2017) Peng Zhang et al.   Scientific Reports

Mechanistic study of TRPM2-Ca2+-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition

(2016) Qian Wang et al.   Autophagy

Functional role of TRP channels in modulating ER stress and Autophagy

(2016) Pramod Sukumaran et al.   CELL CALCIUM

Natural product modulators of transient receptor potential (TRP) channels as potential anti-cancer agents

(2016) Tiago Rodrigues et al.   CHEMICAL SOCIETY REVIEWS

Activation of Transient Receptor Potential Vanilloid 4 Promotes the Proliferation of Stem Cells in the Adult Hippocampal Dentate Gyrus

(2016) Yujing Tian et al.   MOLECULAR NEUROBIOLOGY

TRPV4: Molecular Conductor of a Diverse Orchestra

(2016) John P. M. White et al.   PHYSIOLOGICAL REVIEWS

TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway

(2016) Roslin J. Thoppil et al.   Oncotarget

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Transient receptor potential vanilloid 4 inhibits rat HSC-T6 apoptosis through induction of autophagy

(2015) Lei Zhan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancer

(2015) S-J Kim et al.   ONCOGENE

Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy

(2015) R K Adapala et al.   ONCOGENE

Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways

(2015) P Jie et al.   Cell Death & Disease

TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation

(2015) Roslin J. Thoppil et al.   Scientific Reports

PTEN

(2014) Carolyn A. Worby et al.   Annual Review of Biochemistry

Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells

(2014) Chuan-Ming Xie et al.   Autophagy

TRPM3 and miR-204 Establish a Regulatory Circuit that Controls Oncogenic Autophagy in Clear Cell Renal Cell Carcinoma

(2014) Daniel P. Hall et al.   CANCER CELL

Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes

(2014) Attila Oláh et al.   JOURNAL OF CLINICAL INVESTIGATION

Transient Receptor Potential Vanilloid 4 (TRPV4) Is Downregulated in Keratinocytes in Human Non-Melanoma Skin Cancer

(2014) Camilla Fusi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The puzzle of TRPV4 channelopathies

(2013) Bernd Nilius et al.   EMBO REPORTS

Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression

(2013) Rachana Patel et al.   JOURNAL OF CLINICAL INVESTIGATION

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia

(2012) Olena Butenko et al.   PLoS One

Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

(2011) Min Sup Song et al.   CELL

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling

(2011) A Fiorio Pla et al.   ONCOGENE

Activation of Trpv4 Reduces the Hyperproliferative Phenotype of Cystic Cholangiocytes From an Animal Model of ARPKD

(2010) Sergio A. Gradilone et al.   GASTROENTEROLOGY

Essential Role of TRPC6 Channels in G2/M Phase Transition and Development of Human Glioma

(2010) Xia Ding et al.   JNCI-Journal of the National Cancer Institute

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

(2010) W. Everaerts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer

(2009) Y Shi et al.   GUT

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transient receptor potential channel C3 contributes to the progression of human ovarian cancer

(2009) S L Yang et al.   ONCOGENE

N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

(2008) K. S. Thorneloe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS