National Cancer Institute Alliance for nanotechnology in cancer—Catalyzing research and translation toward novel cancer diagnostics and therapeutics

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

NCI Alliance for Nanotechnology in Cancer – from academic research to clinical interventions

(2019) Piotr Grodzinski et al.   BIOMEDICAL MICRODEVICES

Melanocortin-1 Receptor-Targeting Ultrasmall Silica Nanoparticles for Dual-Modality Human Melanoma Imaging

(2018) Feng Chen et al.   ACS Applied Materials & Interfaces

Smaller CpG-Conjugated Gold Nanoconstructs Achieve Higher Targeting Specificity of Immune Activation

(2018) Jun Yue et al.   ACS Applied Materials & Interfaces

Big Potential from Small Agents: Nanoparticles for Imaging-Based Companion Diagnostics

(2018) Emily B. Ehlerding et al.   ACS Nano

Estimation of clinical trial success rates and related parameters

(2018) Chi Heem Wong et al.   BIOSTATISTICS

Emerging trends in the immunotherapy of pancreatic cancer

(2018) Kasturi Banerjee et al.   CANCER LETTERS

Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation

(2018) Susan M. Keating et al.   CTS-Clinical and Translational Science

Enhancing proteasome-inhibitory activity and specificity of bortezomib by CD38 targeted nanoparticles in multiple myeloma

(2018) Pilar de la Puente et al.   JOURNAL OF CONTROLLED RELEASE

Conjugation Chemistry-Dependent T-Cell Activation with Spherical Nucleic Acids

(2018) Kacper Skakuj et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Treatment of Canine Oral Melanoma with Nanotechnology-Based Immunotherapy and Radiation

(2018) P. Jack Hoopes et al.   MOLECULAR PHARMACEUTICS

Acoustically modulated magnetic resonance imaging of gas-filled protein nanostructures

(2018) George J. Lu et al.   NATURE MATERIALS

A kinetic investigation of interacting, stimulated T cells identifies conditions for rapid functional enhancement, minimal phenotype differentiation, and improved adoptive cell transfer tumor eradication

(2018) Jing Zhou et al.   PLoS One

Molecular spherical nucleic acids

(2018) Hui Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy

(2018) Kaiyuan Ni et al.   Nature Communications

Low-dose X-ray radiotherapy–radiodynamic therapy via nanoscale metal–organic frameworks enhances checkpoint blockade immunotherapy

(2018) Kuangda Lu et al.   Nature Biomedical Engineering

Nanoscale Metal–Organic Layers for Radiotherapy–Radiodynamic Therapy

(2018) Guangxu Lan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy

(2018) Kaiyuan Ni et al.   Nature Communications

Novel window for cancer nanotheranostics: non-invasive ocular assessments of tumor growth and nanotherapeutic treatment efficacy in vivo

(2018) Mayank Goswami et al.   Biomedical Optics Express

Magnetoresistive biosensors with on-chip pulsed excitation and magnetic correlated double sampling

(2018) Kyunglok Kim et al.   Scientific Reports

Measuring the knowledge translation and convergence in pharmaceutical innovation by funding-science-technology-innovation linkages analysis

(2018) Jian Du et al.   Journal of Informetrics

Ultrasound Molecular Imaging With BR55 in Patients With Breast and Ovarian Lesions: First-in-Human Results

(2017) Jürgen K. Willmann et al.   JOURNAL OF CLINICAL ONCOLOGY

Synthetic nanovaccines for immunotherapy

(2017) Min Luo et al.   JOURNAL OF CONTROLLED RELEASE

An Assay Based on SAMDI Mass Spectrometry for Profiling Protein Interaction Domains

(2017) Patrick T. O’Kane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tumor-Penetrating Nanosystem Strongly Suppresses Breast Tumor Growth

(2017) Shweta Sharma et al.   NANO LETTERS

The evolving landscape of drug products containing nanomaterials in the United States

(2017) Sheetal R. D'Mello et al.   Nature Nanotechnology

Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

(2017) Yuanzeng Min et al.   Nature Nanotechnology

Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice

(2017) Moustafa R. K. Ali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression

(2017) Jianqin Lu et al.   Nature Communications

Therapeutic Targeting of AXL Receptor Tyrosine Kinase Inhibits Tumor Growth and Intraperitoneal Metastasis in Ovarian Cancer Models

(2017) Pinar Kanlikilicer et al.   Molecular Therapy-Nucleic Acids

Magnetic Nanoparticle Facilitated Drug Delivery for Cancer Therapy with Targeted and Image-Guided Approaches

(2016) Jing Huang et al.   ADVANCED FUNCTIONAL MATERIALS

Frequency-Domain Approach To Determine Magnetic Address-Sensor Separation Distance Using the Harmonic Ratio Method

(2016) Colin C. Young et al.   ANALYTICAL CHEMISTRY

A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity

(2016) Zhijian He et al.   BIOMATERIALS

Nanoscale Coordination Polymers Codeliver Chemotherapeutics and siRNAs to Eradicate Tumors of Cisplatin-Resistant Ovarian Cancer

(2016) Chunbai He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas

(2016) Tracey L. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release

(2016) Hitomi Hosoya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular profiling of single circulating tumor cells from lung cancer patients

(2016) Seung-min Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crossing the barrier: treatment of brain tumors using nanochain particles

(2016) Efstathios Karathanasis et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

(2016) Chunbai He et al.   Nature Communications

Liposomes in Drug Delivery: How It All Happened

(2016) Gregory Gregoriadis   Pharmaceutics

Nanoparticle Probes for the Detection of Cancer Biomarkers, Cells, and Tissues by Fluorescence

(2015) Alyssa B. Chinen et al.   CHEMICAL REVIEWS

A Systematic Comparison of 18F-C-SNAT to Established Radiotracer Imaging Agents for the Detection of Tumor Response to Treatment

(2015) T. H. Witney et al.   CLINICAL CANCER RESEARCH

Multifunctional Polymeric Micelles Co-loaded with Anti-Survivin siRNA and Paclitaxel Overcome Drug Resistance in an Animal Model of Ovarian Cancer

(2015) G. Salzano et al.   MOLECULAR CANCER THERAPEUTICS

Rapid and Persistent Delivery of Antigen by Lymph Node Targeting PRINT Nanoparticle Vaccine Carrier To Promote Humoral Immunity

(2015) Sarah N. Mueller et al.   MOLECULAR PHARMACEUTICS

Breaking the depth dependency of phototherapy with Cerenkov radiation and low-radiance-responsive nanophotosensitizers

(2015) Nalinikanth Kotagiri et al.   Nature Nanotechnology

Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core

(2015) Andrew J. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle

(2015) Miles A. Miller et al.   Science Translational Medicine

Intraoperative mapping of sentinel lymph node metastases using a clinically translated ultrasmall silica nanoparticle

(2015) Michelle S. Bradbury et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Sedimentary archaeal amoA gene abundance reflects historic nutrient level and salinity fluctuations in Qinghai Lake, Tibetan Plateau

(2015) Jian Yang et al.   Scientific Reports

Nanostructure Embedded Microchips for Detection, Isolation, and Characterization of Circulating Tumor Cells

(2014) Millicent Lin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Future Opportunities in Cancer Nanotechnology--NCI Strategic Workshop Report

(2014) P. Grodzinski et al.   CANCER RESEARCH

Dual Targeting of Integrin  v 3 and Matrix Metalloproteinase-2 for Optical Imaging of Tumors and Chemotherapeutic Delivery

(2014) J. L. Crisp et al.   MOLECULAR CANCER THERAPEUTICS

Biogenic gas nanostructures as ultrasonic molecular reporters

(2014) Mikhail G. Shapiro et al.   Nature Nanotechnology

NanoFlares for the detection, isolation, and culture of live tumor cells from human blood

(2014) Tiffany L. Halo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NCI investment in nanotechnology: achievements and challenges for the future

(2014) Anthony Dickherber et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

A first generation compact microbeam radiation therapy system based on carbon nanotube X-ray technology

(2013) M. Hadsell et al.   APPLIED PHYSICS LETTERS

Engineering multi-stage nanovectors for controlled degradation and tunable release kinetics

(2013) Jonathan O. Martinez et al.   BIOMATERIALS

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

(2013) U. Prabhakar et al.   CANCER RESEARCH

Enhancing Chemotherapy Response with Sustained EphA2 Silencing Using Multistage Vector Delivery

(2013) H. Shen et al.   CLINICAL CANCER RESEARCH

Emerging protein array technologies for proteomics

(2013) Jung-Rok Lee et al.   Expert Review of Proteomics

Imaging Primary Mouse Sarcomas After Radiation Therapy Using Cathepsin-Activatable Fluorescent Imaging Agents

(2013) Kyle C. Cuneo et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

High-sensitivity, real-time, ratiometric imaging of surface-enhanced Raman scattering nanoparticles with a clinically translatable Raman endoscope device

(2013) Ellis Garai et al.   JOURNAL OF BIOMEDICAL OPTICS

Multifunctional nanoparticles co-delivering Trp2 peptide and CpG adjuvant induce potent cytotoxic T-lymphocyte response against melanoma and its lung metastasis

(2013) Zhenghong Xu et al.   JOURNAL OF CONTROLLED RELEASE

Measuring single cell mass, volume, and density with dual suspended microchannel resonators

(2013) Andrea K. Bryan et al.   LAB ON A CHIP

Intravenous Delivery of siRNA Targeting CD47 Effectively Inhibits Melanoma Tumor Growth and Lung Metastasis

(2013) Yuhua Wang et al.   MOLECULAR THERAPY

Nanoparticles for cancer imaging: The good, the bad, and the promise

(2013) Sandra Chapman et al.   Nano Today

Biotargeted nanomedicines for cancer: six tenets before you begin

(2013) Michael S Goldberg et al.   Nanomedicine

Targeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells

(2013) Wenxue Chen et al.   Nanomedicine

Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance

(2013) Arezou A. Ghazani et al.   Nanomedicine-Nanotechnology Biology and Medicine

Fluorescent Affibody Peptide Penetration in Glioma Margin Is Superior to Full Antibody

(2013) Kristian Sexton et al.   PLoS One

Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma

(2013) S. A. Jensen et al.   Science Translational Medicine

Multifunctional T-cell Analyses to Study Response and Progression in Adoptive Cell Transfer Immunotherapy

(2013) Chao Ma et al.   Cancer Discovery

Scanometric MicroRNA Array Profiling of Prostate Cancer Markers Using Spherical Nucleic Acid–Gold Nanoparticle Conjugates

(2012) Ali H. Alhasan et al.   ANALYTICAL CHEMISTRY

Multiplexed Nanoflares: mRNA Detection in Live Cells

(2012) Andrew E. Prigodich et al.   ANALYTICAL CHEMISTRY

Porous silicon nanocarriers for dual targeting tumor associated endothelial cells and macrophages in stroma of orthotopic human pancreatic cancers

(2012) Kenji Yokoi et al.   CANCER LETTERS

Genome-wide Single-Cell Analysis of Recombination Activity and De Novo Mutation Rates in Human Sperm

(2012) Jianbin Wang et al.   CELL

Common pitfalls in nanotechnology: lessons learned from NCI's Nanotechnology Characterization Laboratory

(2012) Rachael M. Crist et al.   Integrative Biology

Cellular Delivery of Doxorubicin via pH-Controlled Hydrazone Linkage Using Multifunctional Nano Vehicle Based on Poly(β-L-Malic Acid)

(2012) Rameshwar Patil et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synergistic Combinations of Multiple Chemotherapeutic Agents in High Capacity Poly(2-oxazoline) Micelles

(2012) Yingchao Han et al.   MOLECULAR PHARMACEUTICS

Quantitating Cell–Cell Interaction Functions with Applications to Glioblastoma Multiforme Cancer Cells

(2012) Jun Wang et al.   NANO LETTERS

Company Profile: Kindling translational cancer nanotechnology research

(2012) Sandra Chapman et al.   Nanomedicine

A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle

(2012) Moritz F Kircher et al.   NATURE MEDICINE

M13-templated magnetic nanoparticles for targeted in vivo imaging of prostate cancer

(2012) Debadyuti Ghosh et al.   Nature Nanotechnology

Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4

(2012) Y. Ren et al.   Science Translational Medicine

A Dense Poly(Ethylene Glycol) Coating Improves Penetration of Large Polymeric Nanoparticles Within Brain Tissue

(2012) E. A. Nance et al.   Science Translational Medicine

PRINT: A Novel Platform Toward Shape and Size Specific Nanoparticle Theranostics

(2011) Jillian L. Perry et al.   ACCOUNTS OF CHEMICAL RESEARCH

Peptide-conjugated polymeric micellar nanoparticles for Dual SPECT and optical imaging of EphB4 receptors in prostate cancer xenografts

(2011) Rui Zhang et al.   BIOMATERIALS

P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment

(2011) A. K. Azab et al.   BLOOD

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers

(2011) Carlee E. Ashley et al.   NATURE MATERIALS

A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells

(2011) Chao Ma et al.   NATURE MEDICINE

Recent Advances from the National Cancer Institute Alliance for Nanotechnology in Cancer

(2010) Dorothy Farrell et al.   ACS Nano

Development and applications of photo-triggered theranostic agents

(2010) Prakash Rai et al.   ADVANCED DRUG DELIVERY REVIEWS

Strategic Workshops on Cancer Nanotechnology

(2010) Larry A. Nagahara et al.   CANCER RESEARCH

Nanoparticle-based theragnostics: Integrating diagnostic and therapeutic potentials in nanomedicine

(2010) Chen Fang et al.   JOURNAL OF CONTROLLED RELEASE

Polymer-Caged Nanobins for Synergistic Cisplatin−Doxorubicin Combination Chemotherapy

(2010) Sang-Min Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Tumor-specific imaging through progression elevated gene-3 promoter-driven gene expression

(2010) Hyo-eun C Bhang et al.   NATURE MEDICINE

Design and feasibility studies of a stationary digital breast tomosynthesis system

(2010) G. Yang et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Nanotechnology-Based Cancer Therapeutics—Promise and Challenge—Lessons Learned Through the NCI Alliance for Nanotechnology in Cancer

(2010) Dorothy Farrell et al.   PHARMACEUTICAL RESEARCH

Magnetic Luminescent Porous Silicon Microparticles for Localized Delivery of Molecular Drug Payloads

(2010) Luo Gu et al.   Small

Short-term molecular polarization of cells on symmetric and asymmetric micropatterns

(2010) Kristiana Kandere-Grzybowska et al.   Soft Matter

Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges

(2010) Xiaoxiao He et al.   TRENDS IN MOLECULAR MEDICINE

The NCI Alliance for Nanotechnology in Cancer: achievement and path forward

(2010) Krzysztof Ptak et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Tumor Targeting and Imaging in Live Animals with Functionalized Semiconductor Quantum Rods

(2009) Ken-Tye Yong et al.   ACS Applied Materials & Interfaces

Design and development of IT-101, a cyclodextrin-containing polymer conjugate of camptothecin

(2009) Mark E. Davis   ADVANCED DRUG DELIVERY REVIEWS

Targeting the efficacy of a dendrimer-based nanotherapeutic in heterogeneous xenograft tumors in vivo

(2009) Andrzej Myc et al.   ANTI-CANCER DRUGS

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

Modular Nucleic Acid Assembled p/MHC Microarrays for Multiplexed Sorting of Antigen-Specific T Cells

(2009) Gabriel A. Kwong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-powered microfluidic chips for multiplexed protein assays from whole blood

(2009) Lidong Qin et al.   LAB ON A CHIP

An integrated microfluidic device for large-scale in situ click chemistry screening

(2009) Yanju Wang et al.   LAB ON A CHIP

Coadministration of Paclitaxel and Curcumin in Nanoemulsion Formulations To Overcome Multidrug Resistance in Tumor Cells

(2009) Srinivas Ganta et al.   MOLECULAR PHARMACEUTICS

Radioactive gold nanoparticles in cancer therapy: therapeutic efficacy studies of GA-198AuNP nanoconstruct in prostate tumor–bearing mice

(2009) Nripen Chanda et al.   Nanomedicine-Nanotechnology Biology and Medicine

A biocompatible condensation reaction for controlled assembly of nanostructures in living cells

(2009) Gaolin Liang et al.   Nature Chemistry

Rapid detection and profiling of cancer cells in fine-needle aspirates

(2009) H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanomaterial standards for efficacy and toxicity assessment

(2009) Pavan P. Adiseshaiah et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Porous silicon in drug delivery devices and materials☆

(2008) E ANGLIN et al.   ADVANCED DRUG DELIVERY REVIEWS

Minute dosages of ανβ3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbits

(2008) Patrick M. Winter et al.   FASEB JOURNAL

Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood

(2008) Rong Fan et al.   NATURE BIOTECHNOLOGY