Cellular stress leads to the formation of membraneless stress assemblies in eukaryotic cells

Single-Molecule Imaging of mRNA Localization and Regulation during the Integrated Stress Response

(2019) Johannes H. Wilbertz et al.   MOLECULAR CELL

Ribosomal RNA genes shape chromatin domains associating with the nucleolus

(2019) Ariadna Picart-Picolo et al.   Nucleus

Stress-induced mRNP granules: Form and function of processing bodies and stress granules

(2019) Anna R. Guzikowski et al.   Wiley Interdisciplinary Reviews-RNA

Coming together to define membrane contact sites

(2019) Luca Scorrano et al.   Nature Communications

Membraneless organelles: P granules in C. elegans

(2019) Elisabeth A. Marnik et al.   TRAFFIC

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation

(2019) Brian Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos

(2019) Andrea Putnam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic Recruitment of Single RNAs to Processing Bodies Depends on RNA Functionality

(2019) Sethuramasundaram Pitchiaya et al.   MOLECULAR CELL

Phase Separation Comes of Age: From Phenomenology to Single Molecules

(2019) Aritra Chowdhury et al.   MOLECULAR CELL

ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97

(2019) Bo Wang et al.   MOLECULAR CELL

CO 2 ‐fixing liquid droplets: Towards a dissection of the microalgal pyrenoid

(2019) Tobias Wunder et al.   TRAFFIC

Germ granules in Drosophila

(2019) Tatjana Trcek et al.   TRAFFIC

Neuronal ribonucleoprotein granules: Dynamic sensors of localized signals

(2019) Nadia Formicola et al.   TRAFFIC

P-Bodies: Composition, Properties, and Functions

(2018) Yang Luo et al.   BIOCHEMISTRY

It Pays To Be in Phase

(2018) Alan K. Itakura et al.   BIOCHEMISTRY

Neuronal RNP granules: from physiological to pathological assemblies

(2018) Fabienne De Graeve et al.   BIOLOGICAL CHEMISTRY

Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites

(2018) Takuya Yoshizawa et al.   CELL

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

(2018) Mario Hofweber et al.   CELL

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules

(2018) Sebastian Markmiller et al.   CELL

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

(2018) Lin Guo et al.   CELL

PML nuclear bodies: from architecture to function

(2018) Valérie Lallemand-Breitenbach et al.   CURRENT OPINION IN CELL BIOLOGY

The solvent side of proteinaceous membrane-less organelles in light of aqueous two-phase systems

(2018) Boris Y. Zaslavsky et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Systematic Characterization of Stress-Induced RNA Granulation

(2018) Sim Namkoong et al.   MOLECULAR CELL

mRNA structure determines specificity of a polyQ-driven phase separation

(2018) Erin M. Langdon et al.   SCIENCE

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks

(2018) Michael P. Hughes et al.   SCIENCE

Phase separation of a yeast prion protein promotes cellular fitness

(2018) Titus M. Franzmann et al.   SCIENCE

Context-dependent deposition and regulation of mRNAs in P-bodies

(2018) Congwei Wang et al.   eLife

Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy

(2018) Lara Marrone et al.   Stem Cell Reports

Emerging Roles for Intermolecular RNA-RNA Interactions in RNP Assemblies

(2018) Briana Van Treeck et al.   CELL

The molecular language of membraneless organelles

(2018) Edward Gomes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic starvation induces non-canonical pro-death stress granules

(2018) Lucas C. Reineke et al.   JOURNAL OF CELL SCIENCE

Multiple Modes of Protein–Protein Interactions Promote RNP Granule Assembly

(2018) Tanja Mittag et al.   JOURNAL OF MOLECULAR BIOLOGY

Kinase-controlled phase transition of membraneless organelles in mitosis

(2018) Arpan Kumar Rai et al.   NATURE

Analysis of eIF2B bodies and their relationships with stress granules and P-bodies

(2018) Stephanie L. Moon et al.   Scientific Reports

Friend or foe — post-translational modifications as regulators of phase separation and RNP granule dynamics

(2018) Mario Hofweber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mRNP architecture in translating and stress conditions reveals an ordered pathway of mRNP compaction

(2018) Anthony Khong et al.   JOURNAL OF CELL BIOLOGY

A Systems-Level Study Reveals Regulators of Membrane-less Organelles in Human Cells

(2018) Doris Berchtold et al.   MOLECULAR CELL

The phase separation underlying the pyrenoid-based microalgal Rubisco supercharger

(2018) Tobias Wunder et al.   Nature Communications

Conformational preferences and phase behavior of intrinsically disordered low complexity sequences: insights from multiscale simulations

(2018) Kiersten M Ruff et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Stress-specific differences in assembly and composition of stress granules and related foci

(2017) Anaïs Aulas et al.   JOURNAL OF CELL SCIENCE

P-Body Purification Reveals the Condensation of Repressed mRNA Regulons

(2017) Arnaud Hubstenberger et al.   MOLECULAR CELL

The Dynamics of mRNA Turnover Revealed by Single-Molecule Imaging in Single Cells

(2017) Ivana Horvathova et al.   MOLECULAR CELL

Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress

(2017) Shady Saad et al.   NATURE CELL BIOLOGY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation

(2017) Angelica Aguilera-Gomez et al.   Cell Reports

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles

(2016) Kyung-Ha Lee et al.   CELL

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Droplet organelles?

(2016) Edward M Courchaine et al.   EMBO JOURNAL

Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications

(2016) Alaji Bah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein sorting at the ER–Golgi interface

(2016) Natalia Gomez-Navarro et al.   JOURNAL OF CELL BIOLOGY

Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization

(2016) Jason A. West et al.   JOURNAL OF CELL BIOLOGY

G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits

(2016) Nancy Kedersha et al.   JOURNAL OF CELL BIOLOGY

Sumoylation of eIF4A2 affects stress granule formation

(2016) Jirapas Jongjitwimol et al.   JOURNAL OF CELL SCIENCE

Emerging Role of PML Nuclear Bodies in Innate Immune Signaling

(2016) Myriam Scherer et al.   JOURNAL OF VIROLOGY

Engineering therapeutic protein disaggregases

(2016) James Shorter   MOLECULAR BIOLOGY OF THE CELL

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

Localized Translation of gurken/TGF-α mRNA during Axis Specification Is Controlled by Access to Orb/CPEB on Processing Bodies

(2016) Alexander Davidson et al.   Cell Reports

In vivo vizualisation of mono-ADP-ribosylation by dPARP16 upon amino-acid starvation

(2016) Angelica Aguilera-Gomez et al.   eLife

A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy

(2016) Matthias Christoph Munder et al.   eLife

Distinct stages in stress granule assembly and disassembly

(2016) Joshua R Wheeler et al.   eLife

SEC16 in COPII coat dynamics at ER exit sites

(2015) Joep Sprangers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Wispy and Orb cooperate in the cytoplasmic polyadenylation of localizedgurkenmRNA

(2015) Amanda Norvell et al.   DEVELOPMENTAL DYNAMICS

TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules

(2015) Irena Jevtov et al.   JOURNAL OF CELL SCIENCE

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

PrionW: a server to identify proteins containing glutamine/asparagine rich prion-like domains and their amyloid cores

(2015) Rafael Zambrano et al.   NUCLEIC ACIDS RESEARCH

Amyloids or prions? That is the question

(2015) Raimon Sabate et al.   Prion

Drosophila germ granules are structured and contain homotypic mRNA clusters

(2015) Tatjana Trcek et al.   Nature Communications

Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules

(2015) Sonja Kroschwald et al.   eLife

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Poly(ADP-ribose): An organizer of cellular architecture

(2014) Anthony K.L. Leung   JOURNAL OF CELL BIOLOGY

The polysome-associated proteins Scp160 and Bfr1 prevent P body formation under normal growth conditions

(2014) J. Weidner et al.   JOURNAL OF CELL SCIENCE

Cytosolic pH Regulates Cell Growth through Distinct GTPases, Arf1 and Gtr1, to Promote Ras/PKA and TORC1 Activity

(2014) Reinhard Dechant et al.   MOLECULAR CELL

Promoter sequences direct cytoplasmic localization and translation of mRNAs during starvation in yeast

(2014) Brian M. Zid et al.   NATURE

A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation

(2014) Margarita Zacharogianni et al.   eLife

Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation

(2014) Ivana Petrovska et al.   eLife

Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function

(2013) J. Ross Buchan et al.   CELL

Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling

(2013) Frank Wippich et al.   CELL

The eIF2α kinases: their structures and functions

(2013) Neysan Donnelly et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Formation and dissociation of proteasome storage granules are regulated by cytosolic pH

(2013) Lee Zeev Peters et al.   JOURNAL OF CELL BIOLOGY

Phase transitions and size scaling of membrane-less organelles

(2013) Clifford P. Brangwynne   JOURNAL OF CELL BIOLOGY

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress

(2013) Reddy Ranjith K. Sama et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Vesicular transport earns a Nobel

(2013) Juan S. Bonifacino   TRENDS IN CELL BIOLOGY

JC Virus Intranuclear Inclusions Associated with PML-NBs

(2012) Yukiko Shishido-Hara et al.   AMERICAN JOURNAL OF PATHOLOGY

Dynamic Reorganization of Metabolic Enzymes into Intracellular Bodies

(2012) Jeremy D. O'Connell et al.   Annual Review of Cell and Developmental Biology

Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Nonamyloid Clients

(2012) Morgan E. DeSantis et al.   CELL

Getting RNA and Protein in Phase

(2012) Stephanie C. Weber et al.   CELL

Alternative 3′-end processing of long noncoding RNA initiates construction of nuclear paraspeckles

(2012) Takao Naganuma et al.   EMBO JOURNAL

Processing Body and Stress Granule Assembly Occur by Independent and Differentially Regulated Pathways in Saccharomyces cerevisiae

(2012) K. H. Shah et al.   GENETICS

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Drosophila patterning is established by differential association of mRNAs with P bodies

(2012) Timothy T. Weil et al.   NATURE CELL BIOLOGY

Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules

(2012) Ken Fujimura et al.   NUCLEIC ACIDS RESEARCH

Reversible response of protein localization and microtubule organization to nutrient stress during Drosophila early oogenesis

(2011) Yuko Shimada et al.   DEVELOPMENTAL BIOLOGY

Beyond Stereospecificity: Liquids and Mesoscale Organization of Cytoplasm

(2011) Anthony A. Hyman et al.   DEVELOPMENTAL CELL

U bodies respond to nutrient stress in Drosophila

(2011) Mickey Buckingham et al.   EXPERIMENTAL CELL RESEARCH

Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR

(2011) C. K. Damgaard et al.   GENES & DEVELOPMENT

The cAMP-Dependent Protein Kinase Signaling Pathway Is a Key Regulator of P Body Foci Formation

(2011) Vidhya Ramachandran et al.   MOLECULAR CELL

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity

(2010) Tjakko J. van Ham et al.   CELL

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

Vgl1, a multi-KH domain protein, is a novel component of the fission yeast stress granules required for cell survival under thermal stress

(2010) W.-L. Wen et al.   NUCLEIC ACIDS RESEARCH

Cellular stress induces cytoplasmic RNA granules in fission yeast

(2010) D. Nilsson et al.   RNA

The Nucleolus

(2010) T. Pederson   Cold Spring Harbor Perspectives in Biology

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

Stress granules

(2009) Paul Anderson et al.   CURRENT BIOLOGY

The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body–P body pathway

(2009) Lin Lee et al.   DEVELOPMENTAL BIOLOGY

Unravelling the ultrastructure of stress granules and associated P-bodies in human cells

(2009) S. Souquere et al.   JOURNAL OF CELL SCIENCE

Robust heat shock induces eIF2 -phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae

(2009) T. Grousl et al.   JOURNAL OF CELL SCIENCE

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation

(2009) R. Narayanaswamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific and global regulation of mRNA stability during osmotic stress in Saccharomyces cerevisiae

(2009) L. Romero-Santacreu et al.   RNA

Metazoan stress granule assembly is mediated by P-eIF2 -dependent and -independent mechanisms

(2009) N. G. Farny et al.   RNA

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

(2008) Yan Zeng et al.   BIOCHEMICAL JOURNAL

P bodies promote stress granule assembly inSaccharomyces cerevisiae

(2008) J. Ross Buchan et al.   JOURNAL OF CELL BIOLOGY

Reversible cytoplasmic localization of the proteasome in quiescent yeast cells

(2008) Damien Laporte et al.   JOURNAL OF CELL BIOLOGY

Translationally Repressed mRNA Transiently Cycles through Stress Granules during Stress

(2008) Stephanie Mollet et al.   MOLECULAR BIOLOGY OF THE CELL

Codependent Functions of RSK2 and the Apoptosis-Promoting Factor TIA-1 in Stress Granule Assembly and Cell Survival

(2008) T.S. Karin Eisinger-Mathason et al.   MOLECULAR CELL

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

(2008) Kyoko Arimoto et al.   NATURE CELL BIOLOGY

Stress granules: the Tao of RNA triage

(2008) Paul Anderson et al.   TRENDS IN BIOCHEMICAL SCIENCES