Neuronal ribonucleoprotein granules: Dynamic sensors of localized signals

Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

(2019) Jean-Michel Cioni et al.   CELL

Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity

(2019) Vidhya Rangaraju et al.   CELL

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation

(2019) Brian Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

(2019) Peipei Zhang et al.   eLife

The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivo

(2019) Jeshlee Vijayakumar et al.   Nature Communications

Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions

(2018) Erik W. Martin et al.   BIOCHEMISTRY

Neuronal RNP granules: from physiological to pathological assemblies

(2018) Fabienne De Graeve et al.   BIOLOGICAL CHEMISTRY

mRNP assembly, axonal transport, and local translation in neurodegenerative diseases

(2018) Bilal Khalil et al.   BRAIN RESEARCH

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

(2018) Mario Hofweber et al.   CELL

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

(2018) Seema Qamar et al.   CELL

Advances in Understanding Stimulus-Responsive Phase Behavior of Intrinsically Disordered Protein Polymers

(2018) Kiersten M. Ruff et al.   JOURNAL OF MOLECULAR BIOLOGY

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome

(2018) Roberta Cagnetta et al.   NEURON

mRNA structure determines specificity of a polyQ-driven phase separation

(2018) Erin M. Langdon et al.   SCIENCE

Phase separation of a yeast prion protein promotes cellular fitness

(2018) Titus M. Franzmann et al.   SCIENCE

Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation

(2018) Anouar Khayachi et al.   Nature Communications

TIA-1 Self-Multimerization, Phase Separation, and Recruitment into Stress Granules Are Dynamically Regulated by Zn 2+

(2018) Joseph B. Rayman et al.   Cell Reports

Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly

(2018) David S.W. Protter et al.   Cell Reports

Reconstituted Postsynaptic Density as a Molecular Platform for Understanding Synapse Formation and Plasticity

(2018) Menglong Zeng et al.   CELL

Emerging Roles for Intermolecular RNA-RNA Interactions in RNP Assemblies

(2018) Briana Van Treeck et al.   CELL

Who's In and Who's Out—Compositional Control of Biomolecular Condensates

(2018) Jonathon A. Ditlev et al.   JOURNAL OF MOLECULAR BIOLOGY

Multiple Modes of Protein–Protein Interactions Promote RNP Granule Assembly

(2018) Tanja Mittag et al.   JOURNAL OF MOLECULAR BIOLOGY

hnRNPs interacting with mRNA localization motifs define axonal RNA regulons

(2018) Seung Joon Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

C9orf72-mediated ALS and FTD: multiple pathways to disease

(2018) Rubika Balendra et al.   Nature Reviews Neurology

Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons

(2018) Benita Turner-Bridger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration

(2018) Pabitra K. Sahoo et al.   Nature Communications

Friend or foe — post-translational modifications as regulators of phase separation and RNP granule dynamics

(2018) Mario Hofweber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ageing as a risk factor for ALS/FTD

(2017) Teresa Niccoli et al.   HUMAN MOLECULAR GENETICS

Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation

(2017) Léa Lepelletier et al.   JOURNAL OF NEUROSCIENCE

Components of RNA granules affect their localization and dynamics in neuronal dendrites

(2017) Kazuhiko Mitsumori et al.   MOLECULAR BIOLOGY OF THE CELL

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

(2017) Steven Boeynaems et al.   MOLECULAR CELL

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo

(2017) Hovy Ho-Wai Wong et al.   NEURON

Synaptic Vesicle Clusters at Synapses: A Distinct Liquid Phase?

(2017) Dragomir Milovanovic et al.   NEURON

Compartmentalized Signaling in Neurons: From Cell Biology to Neuroscience

(2017) Marco Terenzio et al.   NEURON

Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons

(2017) Pallavi P. Gopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP as a biological hydrotrope

(2017) Avinash Patel et al.   SCIENCE

ALS/FTD-Associated C9ORF72 Repeat RNA Promotes Phase Transitions In Vitro and in Cells

(2017) Marta M. Fay et al.   Cell Reports

The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly

(2017) Paul G. Donlin-Asp et al.   Cell Reports

Are aberrant phase transitions a driver of cellular aging?

(2016) Simon Alberti et al.   BIOESSAYS

C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles

(2016) Kyung-Ha Lee et al.   CELL

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

A role for the survival of motor neuron protein in mRNP assembly and transport

(2016) Paul G Donlin-Asp et al.   CURRENT OPINION IN NEUROBIOLOGY

Altered mRNP granule dynamics in FTLD pathogenesis

(2016) Hilary A. Bowden et al.   JOURNAL OF NEUROCHEMISTRY

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Nascent Proteome Remodeling following Homeostatic Scaling at Hippocampal Synapses

(2016) Christoph T. Schanzenbächer et al.   NEURON

Long-term memory consolidation: The role of RNA-binding proteins with prion-like domains

(2016) Indulekha P. Sudhakaran et al.   RNA Biology

Translation dynamics of single mRNAs in live cells and neurons

(2016) B. Wu et al.   SCIENCE

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

Hypo- and Hyper-Assembly Diseases of RNA–Protein Complexes

(2016) Siddharth Shukla et al.   TRENDS IN MOLECULAR MEDICINE

The Role of Functional Prion-Like Proteins in the Persistence of Memory

(2016) Kausik Si et al.   Cold Spring Harbor Perspectives in Biology

Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA Granules

(2016) Rachid El Fatimy et al.   PLoS Genetics

Amyloidogenic Oligomerization Transforms Drosophila Orb2 from a Translation Repressor to an Activator

(2015) Mohammed Repon Khan et al.   CELL

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Synaptic control of mRNA translation by reversible assembly of XRN1 bodies

(2015) L. Luchelli et al.   JOURNAL OF CELL SCIENCE

Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome

(2015) M. F. Ifrim et al.   JOURNAL OF NEUROSCIENCE

Disease Mechanisms and Therapeutic Approaches in Spinal Muscular Atrophy

(2015) S. Tisdale et al.   JOURNAL OF NEUROSCIENCE

RNA Controls PolyQ Protein Phase Transitions

(2015) Huaiying Zhang et al.   MOLECULAR CELL

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

(2015) Tetsuro Murakami et al.   NEURON

The CPEB3 Protein Is a Functional Prion that Interacts with the Actin Cytoskeleton

(2015) Joseph S. Stephan et al.   Cell Reports

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Remote Control of Gene Function by Local Translation

(2014) Hosung Jung et al.   CELL

In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics

(2014) Ute Distler et al.   PROTEOMICS

mRNP granules

(2014) J Ross Buchan   RNA Biology

Single  -Actin mRNA Detection in Neurons Reveals a Mechanism for Regulating Its Translatability

(2014) A. R. Buxbaum et al.   SCIENCE

Visualization of Dynamics of Single Endogenous mRNA Labeled in Live Mouse

(2014) H. Y. Park et al.   SCIENCE

Calcium signaling in axon guidance

(2014) Daniel J. Sutherland et al.   TRENDS IN NEUROSCIENCES

Contribution of Orb2A Stability in Regulated Amyloid-Like Oligomerization of Drosophila Orb2

(2014) Erica White-Grindley et al.   PLOS BIOLOGY

Translation and silencing in RNA granules: a tale of sand grains

(2014) Jerónimo Pimentel et al.   Frontiers in Molecular Neuroscience

Protein disorder, prion propensities, and self-organizing macromolecular collectives

(2013) Liliana Malinovska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

(2013) Mani Ramaswami et al.   CELL

Dynamics of survival of motor neuron (SMN) protein interaction with the mRNA-binding protein IMP1 facilitates its trafficking into motor neuron axons

(2013) Claudia Fallini et al.   Developmental Neurobiology

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

Activity-dependent synaptic localization of processing bodies and their role in dendritic structural plasticity

(2013) J.-Y. Oh et al.   JOURNAL OF CELL SCIENCE

Phosphorylation of Zipcode Binding Protein 1 Is Required for Brain-Derived Neurotrophic Factor Signaling of Local  -Actin Synthesis and Growth Cone Turning

(2013) Y. Sasaki et al.   JOURNAL OF NEUROSCIENCE

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Spatial Organization of the Cell Cytoplasm by Position-Dependent Phase Separation

(2013) Chiu Fan Lee et al.   PHYSICAL REVIEW LETTERS

Reactivation of stalled polyribosomes in synaptic plasticity

(2013) T. E. Graber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria Coordinate Sites of Axon Branching through Localized Intra-axonal Protein Synthesis

(2013) Mirela Spillane et al.   Cell Reports

Staufen2 Regulates Neuronal Target RNAs

(2013) Jacki E. Heraud-Farlow et al.   Cell Reports

Interactome of Two Diverse RNA Granules Links mRNA Localization to Translational Repression in Neurons

(2013) Renate Fritzsche et al.   Cell Reports

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

(2012) Oliver D. King et al.   BRAIN RESEARCH

Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory

(2012) Amitabha Majumdar et al.   CELL

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Getting RNA and Protein in Phase

(2012) Stephanie C. Weber et al.   CELL

Principles and roles of mRNA localization in animal development

(2012) C. Medioni et al.   DEVELOPMENT

Spatial arrangement of an RNA zipcode identifies mRNAs under post-transcriptional control

(2012) V. L. Patel et al.   GENES & DEVELOPMENT

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Drosophila CPEB Orb2A Mediates Memory Independent of Its RNA-Binding Domain

(2012) Sebastian Krüttner et al.   NEURON

Functional Complexity of the Axonal Growth Cone: A Proteomic Analysis

(2012) Adriana Estrada-Bernal et al.   PLoS One

Neuronal mRNAs travel singly into dendrites

(2012) M. Batish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the role of TDP-43 and FUS/TLS in ALS and beyond

(2011) Sandrine Da Cruz et al.   CURRENT OPINION IN NEUROBIOLOGY

Mechanisms of dendritic mRNA transport and its role in synaptic tagging

(2011) Michael Doyle et al.   EMBO JOURNAL

Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers

(2011) Martin Mikl et al.   EMBO REPORTS

Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation

(2011) María Verónica Baez et al.   JOURNAL OF CELL BIOLOGY

Long-term Consequences of Repetitive Brain Trauma: Chronic Traumatic Encephalopathy

(2011) Robert A. Stern et al.   PM&R

Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation

(2010) Kausik Si et al.   CELL

Neuronal RNA granule contains ApCPEB1, a novel cytoplasmic polyadenylation element binding protein, in Aplysia sensory neuron

(2010) Yeon-Su Chae et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules

(2010) Daryl A. Bosco et al.   HUMAN MOLECULAR GENETICS

Dendritically Localized Transcripts Are Sorted into Distinct Ribonucleoprotein Particles That Display Fast Directional Motility along Dendrites of Hippocampal Neurons

(2010) F. Tubing et al.   JOURNAL OF NEUROSCIENCE

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

(2010) Andrew C. Elden et al.   NATURE

Characterization of the proteome, diseases and evolution of the human postsynaptic density

(2010) Àlex Bayés et al.   NATURE NEUROSCIENCE

Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue

(2010) Liqun Liu-Yesucevitz et al.   PLoS One

The Me31B DEAD-Box Helicase Localizes to Postsynaptic Foci and Regulates Expression of a CaMKII Reporter mRNA in Dendrites of Drosophila Olfactory Projection Neurons

(2010) Jens Hillebrand et al.   Frontiers in Neural Circuits

TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity

(2009) Brian S. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combinations of DEAD box proteins distinguish distinct types of RNA: Protein complexes in neurons

(2009) Linda C. Miller et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Identification of functional marker proteins in the mammalian growth cone

(2009) M. Nozumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

A Direct Role for FMRP in Activity-Dependent Dendritic mRNA Transport Links Filopodial-Spine Morphogenesis to Fragile X Syndrome

(2008) Jason B. Dictenberg et al.   DEVELOPMENTAL CELL

TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor

(2008) I.-Fan Wang et al.   JOURNAL OF NEUROCHEMISTRY

Dendrites of Mammalian Neurons Contain Specialized P-Body-Like Structures That Respond to Neuronal Activation

(2008) N. Cougot et al.   JOURNAL OF NEUROSCIENCE

Dynamic Interaction between P-Bodies and Transport Ribonucleoprotein Particles in Dendrites of Mature Hippocampal Neurons

(2008) M. Zeitelhofer et al.   JOURNAL OF NEUROSCIENCE

Ca2+microdomains near plasma membrane Ca2+channels: impact on cell function

(2008) Anant B. Parekh   JOURNAL OF PHYSIOLOGY-LONDON

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

(2008) Edor Kabashi et al.   NATURE GENETICS