The Role of Checkpoint Inhibitors in Glioblastoma

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

(2019) Robert M. Samstein et al.   NATURE GENETICS

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

(2019) Timothy F. Cloughesy et al.   NATURE MEDICINE

Temozolomide combined with PD-1 Antibody therapy for mouse orthotopic glioma model

(2018) Bailing Dai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma

(2018) Saskia Roesch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunotherapy in CNS cancers: the role of immune cell trafficking

(2018) Nivedita M Ratnam et al.   NEURO-ONCOLOGY

The Choroid Plexus Functions as a Niche for T-Cell Stimulation Within the Central Nervous System

(2018) Itai Strominger et al.   Frontiers in Immunology

Epacadostat (E) plus pembrolizumab (P) versus pembrolizumab alone in patients (pts) with unresectable or metastatic melanoma: Results of the phase 3 ECHO-301/KEYNOTE-252 study.

(2018) Georgina V. Long et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II study of pembrolizumab or pembrolizumab plus bevacizumab for recurrent glioblastoma (rGBM) patients.

(2018) David A. Reardon et al.   JOURNAL OF CLINICAL ONCOLOGY

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors

(2018) Pakawat Chongsathidkiet et al.   NATURE MEDICINE

Immuno-Oncology: Emerging Targets and Combination Therapies

(2018) Henry T. Marshall et al.   Frontiers in Oncology

Mutant IDH1 regulates the tumor-associated immune system in gliomas

(2017) Nduka M. Amankulor et al.   GENES & DEVELOPMENT

Tim-3 and its role in regulating anti-tumor immunity

(2017) Madhumita Das et al.   IMMUNOLOGICAL REVIEWS

Radiation Therapy for Glioblastoma: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Guideline

(2017) Erik P. Sulman et al.   JOURNAL OF CLINICAL ONCOLOGY

Blocking the PD-1/PD-L1 pathway in glioma: a potential new treatment strategy

(2017) Song Xue et al.   Journal of Hematology & Oncology

Nivolumab for patients with recurrent glioblastoma progressing on bevacizumab: a retrospective case series

(2017) Marc C. Chamberlain et al.   JOURNAL OF NEURO-ONCOLOGY

Immune microenvironment of gliomas

(2017) Anna Gieryng et al.   LABORATORY INVESTIGATION

CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010–2014

(2017) Quinn T Ostrom et al.   NEURO-ONCOLOGY

OS10.3 Randomized Phase 3 Study Evaluating the Efficacy and Safety of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma: CheckMate 143

(2017) D. A. Reardon et al.   NEURO-ONCOLOGY

Lomustine and Bevacizumab in Progressive Glioblastoma

(2017) Wolfgang Wick et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vascular, glial, and lymphatic immune gateways of the central nervous system

(2016) Britta Engelhardt et al.   ACTA NEUROPATHOLOGICA

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Corticosteroids compromise survival in glioblastoma

(2016) Kenneth L. Pitter et al.   BRAIN

Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas

(2016) Jennifer E. Kim et al.   CLINICAL CANCER RESEARCH

Pembrolizumab: first experience with recurrent primary central nervous system (CNS) tumors

(2016) Deborah T. Blumenthal et al.   JOURNAL OF NEURO-ONCOLOGY

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

ATIM-15. A PHASE I TRIAL OF HYPOFRACTIONATED STEREOTACTIC IRRADIATION (HFSRT) WITH PEMBROLIZUMAB AND BEVACIZUMAB IN patients with recurrent high grade gliomas

(2016) Solmaz Sahebjam et al.   NEURO-ONCOLOGY

ATIM-35. RESULTS OF THE PHASE IB KEYNOTE-028 MULTI-COHORT TRIAL OF PEMBROLIZUMAB MONOTHERAPY IN PATIENTS WITH RECURRENT PD-L1-POSITIVE GLIOBLASTOMA MULTIFORME (GBM)

(2016) David A. Reardon et al.   NEURO-ONCOLOGY

Dexamethasone enhances programmed cell death 1 (PD-1) expression during T cell activation: an insight into the optimum application of glucocorticoids in anti-cancer therapy

(2015) Kailin Xing et al.   BMC IMMUNOLOGY

Dexamethasone exerts profound immunologic interference on treatment efficacy for recurrent glioblastoma

(2015) E T Wong et al.   BRITISH JOURNAL OF CANCER

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

(2015) Douglas Marvel et al.   JOURNAL OF CLINICAL INVESTIGATION

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glioma cells escaped from cytotoxicity of temozolomide and vincristine by communicating with human astrocytes

(2015) Weiliang Chen et al.   MEDICAL ONCOLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Immunosuppressive mechanisms in glioblastoma: Fig. 1.

(2015) Edjah K. Nduom et al.   NEURO-ONCOLOGY

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction

(2015) Sherin J. Rouhani et al.   Nature Communications

Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model

(2015) D. A. Reardon et al.   Cancer Immunology Research

Glioma

(2015) Michael Weller et al.   Nature Reviews Disease Primers

Immunosuppressive Mechanisms of Malignant Gliomas: Parallels at Non-CNS Sites

(2015) Powell Perng et al.   Frontiers in Oncology

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival

(2015) Aurelie Poli et al.   Oncotarget

RAGE Expression in Tumor-Associated Macrophages Promotes Angiogenesis in Glioma

(2014) X. Chen et al.   CANCER RESEARCH

Enhancement of T cell recruitment and infiltration into tumours

(2014) C. Oelkrug et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors

(2014) D. A. Wainwright et al.   CLINICAL CANCER RESEARCH

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

A vaccine targeting mutant IDH1 induces antitumour immunity

(2014) Theresa Schumacher et al.   NATURE

A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

(2014) Mark R. Gilbert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma

(2014) Olivier L. Chinot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tolerogenic Properties of Lymphatic Endothelial Cells Are Controlled by the Lymph Node Microenvironment

(2014) Jarish N. Cohen et al.   PLoS One

CNS-specific T cells shape brain function via the choroid plexus

(2013) Kuti Baruch et al.   BRAIN BEHAVIOR AND IMMUNITY

Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas

(2013) Jing Zeng et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Natural killer cells in intracranial neoplasms: presence and therapeutic efficacy against brain tumours

(2013) Justyna Kmiecik et al.   JOURNAL OF NEURO-ONCOLOGY

Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level

(2013) Justyna Kmiecik et al.   JOURNAL OF NEUROIMMUNOLOGY

Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

(2013) Lijun Yang et al.   Journal of Translational Medicine

Immune Heterogeneity of Glioblastoma Subtypes: Extrapolation from the Cancer Genome Atlas

(2013) T. Doucette et al.   Cancer Immunology Research

VEGFA-VEGFR Pathway Blockade Inhibits Tumor-Induced Regulatory T-cell Proliferation in Colorectal Cancer

(2012) M. Terme et al.   CANCER RESEARCH

Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype

(2012) Y. Piao et al.   NEURO-ONCOLOGY

Monitoring of Regulatory T Cell Frequencies and Expression of CTLA-4 on T Cells, before and after DC Vaccination, Can Predict Survival in GBM Patients

(2012) Brendan Fong et al.   PLoS One

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Cell trafficking through the choroid plexus

(2012) Rick B. Meeker et al.   Cell Adhesion & Migration

A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis

(2011) J. Zhang et al.   CARCINOGENESIS

Immunosuppression in Patients with High-Grade Gliomas Treated with Radiation and Temozolomide

(2011) Stuart A. Grossman et al.   CLINICAL CANCER RESEARCH

Galectin-9 and T Cell Immunoglobulin Mucin-3 Pathway Is a Therapeutic Target for Type 1 Diabetes

(2011) Motoko Kanzaki et al.   ENDOCRINOLOGY

Mechanisms of Dendritic Cell Trafficking Across the Blood–brain Barrier

(2011) Divya Sagar et al.   Journal of Neuroimmune Pharmacology

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Immune modulation effects of concomitant temozolomide and radiation therapy on peripheral blood mononuclear cells in patients with glioblastoma multiforme

(2011) C. E. Fadul et al.   NEURO-ONCOLOGY

Hypoxia Potentiates Glioma-Mediated Immunosuppression

(2011) Jun Wei et al.   PLoS One

Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer

(2010) R. K. Shrimali et al.   CANCER RESEARCH

Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients

(2010) T. Di Tomaso et al.   CLINICAL CANCER RESEARCH

Trafficking of immune cells in the central nervous system

(2010) Emma H. Wilson et al.   JOURNAL OF CLINICAL INVESTIGATION

Glioblastoma Cancer-Initiating Cells Inhibit T-Cell Proliferation and Effector Responses by the Signal Transducers and Activators of Transcription 3 Pathway

(2010) J. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Glioma cancer stem cells induce immunosuppressive macrophages/microglia

(2010) Adam Wu et al.   NEURO-ONCOLOGY

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

(2009) Henry S. Friedman et al.   JOURNAL OF CLINICAL ONCOLOGY

Incidence and Prognostic Impact of FoxP3+ Regulatory T Cells in Human Gliomas

(2008) A. B. Heimberger et al.   CLINICAL CANCER RESEARCH

Phase II Trial of Single-Agent Bevacizumab Followed by Bevacizumab Plus Irinotecan at Tumor Progression in Recurrent Glioblastoma

(2008) Teri N. Kreisl et al.   JOURNAL OF CLINICAL ONCOLOGY