Cryptic genetic variation accelerates evolution by opening access to diverse adaptive peaks

Pervasive contingency and entrenchment in a billion years of Hsp90 evolution

(2018) Tyler N. Starr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative evolutionary histories in the sequence space of an ancient protein

(2017) Tyler N. Starr et al.   NATURE

Adaptive benefits from small mutation supplies in an antibiotic resistance enzyme

(2017) Merijn L. M. Salverda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-order epistasis shapes evolutionary trajectories

(2017) Zachary R. Sailer et al.   PLoS Computational Biology

Genetic variation in adaptability and pleiotropy in budding yeast

(2017) Elizabeth R Jerison et al.   eLife

On the (un)predictability of a large intragenic fitness landscape

(2016) Claudia Bank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divergent evolution peaks under intermediate population bottlenecks during bacterial experimental evolution

(2016) Tom Vogwill et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The fitness landscape of a tRNA gene

(2016) C. Li et al.   SCIENCE

Enhancing effect of phenotype mutational robustness on adaptation inEscherichia coli

(2015) Emanuele Rigato et al.   JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

Methods for the directed evolution of proteins

(2015) Michael S. Packer et al.   NATURE REVIEWS GENETICS

Mistranslation drives the evolution of robustness in TEM-1 β-lactamase

(2015) Sinisa Bratulic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pervasive degeneracy and epistasis in a protein-protein interface

(2015) A. I. Podgornaia et al.   SCIENCE

Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes

(2015) Adam C. Palmer et al.   Nature Communications

Cryptic genetic variation can make “irreducible complexity” a common mode of adaptation in sexual populations

(2014) Meredith V. Trotter et al.   EVOLUTION

PAPNC, a novel method to calculate nucleotide diversity from large scale next generation sequencing data

(2014) Wei Shao et al.   JOURNAL OF VIROLOGICAL METHODS

Cryptic genetic variation: evolution's hidden substrate

(2014) Annalise B. Paaby et al.   NATURE REVIEWS GENETICS

Global epistasis makes adaptation predictable despite sequence-level stochasticity

(2014) S. Kryazhimskiy et al.   SCIENCE

Long-read, whole-genome shotgun sequence data for five model organisms

(2014) Kristi E Kim et al.   Scientific Data

Genomic mining of prokaryotic repressors for orthogonal logic gates

(2013) Brynne C Stanton et al.   Nature Chemical Biology

Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish

(2013) N. Rohner et al.   SCIENCE

Predictability of evolution depends nonmonotonically on population size

(2012) I. G. Szendro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme

(2012) Nobuhiko Tokuriki et al.   Nature Communications

Role of Pleiotropy in the Evolution of a Cryptic Developmental Variation in Caenorhabditis elegans

(2012) Fabien Duveau et al.   PLOS BIOLOGY

Preparation of highly efficient electrocompetent Escherichia coli using glycerol/mannitol density step centrifugation

(2011) David J. Warren   ANALYTICAL BIOCHEMISTRY

Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme

(2011) Eric J. Hayden et al.   NATURE

Predicting mutation outcome from early stochastic variation in genetic interaction partners

(2011) Alejandro Burga et al.   NATURE

Initial Mutations Direct Alternative Pathways of Protein Evolution

(2011) Merijn L. M. Salverda et al.   PLoS Genetics

CRYPTIC GENETIC VARIATION AND BODY SIZE EVOLUTION IN THREESPINE STICKLEBACK

(2010) Katrina McGuigan et al.   EVOLUTION

The Rate of Fitness-Valley Crossing in Sexual Populations

(2010) D. B. Weissman et al.   GENETICS

Sequence space and the ongoing expansion of the protein universe

(2010) Inna S. Povolotskaya et al.   NATURE

Compensatory evolution in mitochondrial tRNAs navigates valleys of low fitness

(2010) Margarita V. Meer et al.   NATURE

Phenotypic robustness conferred by apparently redundant transcriptional enhancers

(2010) Nicolás Frankel et al.   NATURE

The molecular evolutionary basis of species formation

(2010) Daven C. Presgraves   NATURE REVIEWS GENETICS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Chaperonin overexpression promotes genetic variation and enzyme evolution

(2009) Nobuhiko Tokuriki et al.   NATURE

Experimental evolution reveals natural selection on standing genetic variation

(2009) Henrique Teotónio et al.   NATURE GENETICS

Detecting gene–gene interactions that underlie human diseases

(2009) Heather J Cordell   NATURE REVIEWS GENETICS

Exploring protein fitness landscapes by directed evolution

(2009) Philip A. Romero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evolutionary consequences of cryptic genetic variation

(2009) Katrina McGuigan et al.   TRENDS IN ECOLOGY & EVOLUTION

Genomic Consequences of Background Effects on scalloped Mutant Expressivity in the Wing of Drosophila melanogaster

(2008) I. Dworkin et al.   GENETICS

Directed enzyme evolution via small and effective neutral drift libraries

(2008) Rinkoo D Gupta et al.   NATURE METHODS