Gating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis

Inverted allosteric coupling between activation and inactivation gates in K+channels

(2018) Alain J. Labro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A conserved glycine harboring disease-associated mutations permits NMDA receptor slow deactivation and high Ca2+ permeability

(2018) Johansen B. Amin et al.   Nature Communications

Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors

(2017) Johansen B. Amin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Channel opening and gating mechanism in AMPA-subtype glutamate receptors

(2017) Edward C. Twomey et al.   NATURE

Hysteresis of KcsA potassium channel's activation– deactivation gating is caused by structural changes at the channel’s selectivity filter

(2017) Cholpon Tilegenova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating

(2017) Maria V. Yelshanskaya et al.   Scientific Reports

Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology

(2017) Kevin K. Ogden et al.   PLoS Genetics

Optocontrol of glutamate receptor activity by single side-chain photoisomerization

(2017) Viktoria Klippenstein et al.   eLife

Control of AMPA receptor activity by the extracellular loops of auxiliary proteins

(2017) Irene Riva et al.   eLife

Dynamics of the Ligand Binding Domain Layer during AMPA Receptor Activation

(2016) Jelena Baranovic et al.   BIOPHYSICAL JOURNAL

Pharmacological Correction of Trafficking Defects in ATP-sensitive Potassium Channels Caused by Sulfonylurea Receptor 1 Mutations

(2016) Gregory M. Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors

(2016) Matthew Alsaloum et al.   JOURNAL OF NEUROSCIENCE

Architecture of fully occupied GluA2 AMPA receptor–TARP complex elucidated by cryo-EM

(2016) Yan Zhao et al.   NATURE

Structural rearrangement of the intracellular domains during AMPA receptor activation

(2016) Linda G. Zachariassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and organization of heteromeric AMPA-type glutamate receptors

(2016) Beatriz Herguedas et al.   SCIENCE

Superactivation of AMPA receptors by auxiliary proteins

(2016) Anna L. Carbone et al.   Nature Communications

Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors

(2016) Maria V. Yelshanskaya et al.   Scientific Reports

Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4

(2016) Christopher I Murray et al.   eLife

Allosteric regulation in NMDA receptors revealed by the genetically encoded photo-cross-linkers

(2016) Meilin Tian et al.   Scientific Reports

Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States

(2014) Katharina L. Dürr et al.   CELL

Photoinactivation of Glutamate Receptors by Genetically Encoded Unnatural Amino Acids

(2014) Viktoria Klippenstein et al.   JOURNAL OF NEUROSCIENCE

X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism

(2014) L. Chen et al.   SCIENCE

Evolutionarily conserved intracellular gate of voltage-dependent sodium channels

(2014) Kevin Oelstrom et al.   Nature Communications

Site-Specific Epitope Tagging of G Protein-Coupled Receptors by Bioorthogonal Modification of a Genetically Encoded Unnatural Amino Acid

(2013) Saranga Naganathan et al.   BIOCHEMISTRY

A Eukaryotic Specific Transmembrane Segment is Required for Tetramerization in AMPA Receptors

(2013) C. L. Salussolia et al.   JOURNAL OF NEUROSCIENCE

Energetic role of the paddle motif in voltage gating of Shaker K+ channels

(2013) Yanping Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Conformational Intermediate in Glutamate Receptor Activation

(2013) Albert Y. Lau et al.   NEURON

Semisynthetic K+ channels show that the constricted conformation of the selectivity filter is not the C-type inactivated state

(2013) P. K. Devaraneni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selectivity filter gating in large-conductance Ca2+-activated K+channels

(2012) Jill Thompson et al.   JOURNAL OF GENERAL PHYSIOLOGY

The voltage-dependent gate in MthK potassium channels is located at the selectivity filter

(2012) David J Posson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Coupled Control of Desensitization and Gating by the Ligand Binding Domain of Glutamate Receptors

(2012) Anna L. Carbone et al.   NEURON

Mechanism of AMPA Receptor Activation by Partial Agonists

(2011) Ahmed H. Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of the M4 Segment with Other Transmembrane Segments Is Required for Surface Expression of Mammalian α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors

(2011) Catherine L. Salussolia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region

(2011) Y. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tracking G-protein-coupled receptor activation using genetically encoded infrared probes

(2010) Shixin Ye et al.   NATURE

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

FTIR analysis of GPCR activation using azido probes

(2009) Shixin Ye et al.   Nature Chemical Biology

Gating at the selectivity filter in cyclic nucleotide-gated channels

(2008) J. E. Contreras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA