An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication

Genome-wide analysis of replication timing by next-generation sequencing with E/L Repli-seq

(2018) Claire Marchal et al.   Nature Protocols

Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins

(2018) Isha Nasa et al.   Science Signaling

Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins

(2018) Isha Nasa et al.   Science Signaling

The ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase

(2018) Miiko Sokka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An intrinsic S/G2 checkpoint enforced by ATR

(2018) Joshua C. Saldivar et al.   SCIENCE

ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1

(2017) Tatiana Moiseeva et al.   Nature Communications

Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1

(2017) Robert C. Alver et al.   Cell Reports

Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage

(2016) Xiangzi Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

4D Visualization of replication foci in mammalian cells corresponding to individual replicons

(2016) V. O. Chagin et al.   Nature Communications

Replication landscape of the human genome

(2016) Nataliya Petryk et al.   Nature Communications

3D replicon distributions arise from stochastic initiation and domino-like DNA replication progression

(2016) D. Löb et al.   Nature Communications

Interaction of Chk1 with Treslin Negatively Regulates the Initiation of Chromosomal DNA Replication

(2015) Cai Guo et al.   MOLECULAR CELL

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage

(2015) Eun-Yeung Gong et al.   Scientific Reports

A chromatin structure-based model accurately predicts DNA replication timing in human cells

(2014) Y. Gindin et al.   Molecular Systems Biology

Topologically associating domains are stable units of replication-timing regulation

(2014) Benjamin D. Pope et al.   NATURE

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

(2013) F. B. Couch et al.   GENES & DEVELOPMENT

Interrogating cAMP-dependent Kinase Signaling in Jurkat T Cells via a Protein Kinase A Targeted Immune-precipitation Phosphoproteomics Approach

(2013) Piero Giansanti et al.   MOLECULAR & CELLULAR PROTEOMICS

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Autoregulatory Mechanisms of Phosphorylation of Checkpoint Kinase 1

(2012) J. Wang et al.   CANCER RESEARCH

Rif1 regulates the replication timing domains on the human genome

(2012) Satoshi Yamazaki et al.   EMBO JOURNAL

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Conserved ATRMec1phosphorylation-independent activation of Chk1 by single amino acid substitution in the GD domain

(2011) Elizabeth Pereira et al.   CELL CYCLE

Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features

(2011) C. Cayrou et al.   GENOME RESEARCH

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Probing protein heterogeneity in the plasma membrane using PALM and pair correlation analysis

(2011) Prabuddha Sengupta et al.   NATURE METHODS

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1

(2011) Melanie Blasius et al.   GENOME BIOLOGY

Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication

(2010) Akiko Kumagai et al.   CELL

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories

(2010) Xin Quan Ge et al.   JOURNAL OF CELL BIOLOGY

Chk1 promotes replication fork progression by controlling replication initiation

(2010) E. Petermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress

(2009) You-Wei Zhang et al.   MOLECULAR CELL

Quantitation of cellular deoxynucleoside triphosphates

(2009) Paola Ferraro et al.   NUCLEIC ACIDS RESEARCH

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity

(2009) M Walker et al.   ONCOGENE

Plx1 is required for chromosomal DNA replication under stressful conditions

(2008) Kristina Trenz et al.   EMBO JOURNAL

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

(2008) D. Wilsker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

(2008) Arkaitz Ibarra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA