Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage

Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation

(2015) Xiangzi Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of Chk1 with Treslin Negatively Regulates the Initiation of Chromosomal DNA Replication

(2015) Cai Guo et al.   MOLECULAR CELL

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage

(2015) Eun-Yeung Gong et al.   Scientific Reports

The Interaction between Checkpoint Kinase 1 (Chk1) and the Minichromosome Maintenance (MCM) Complex Is Required for DNA Damage-induced Chk1 Phosphorylation

(2014) Xiangzi Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UbcH7 regulates 53BP1 stability and DSB repair

(2014) Xiangzi Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of Chk1 in cell biology and cancer therapy

(2013) Youwei Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Autoregulatory Mechanisms of Phosphorylation of Checkpoint Kinase 1

(2012) J. Wang et al.   CANCER RESEARCH

Coupling Cellular Localization and Function of Checkpoint Kinase 1 (Chk1) in Checkpoints and Cell Viability

(2012) Jingna Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma

(2012) Jian Hong et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer

(2012) J Xu et al.   ONCOGENE

Conserved ATRMec1phosphorylation-independent activation of Chk1 by single amino acid substitution in the GD domain

(2011) Elizabeth Pereira et al.   CELL CYCLE

Quantitative Co-Expression of Proteins at the Single Cell Level – Application to a Multimeric FRET Sensor

(2011) Joachim Goedhart et al.   PLoS One

Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints

(2011) N. Pabla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Förster resonance energy transfer as a tool to study photoreceptor biology

(2010) Stephanie C. Hovan et al.   JOURNAL OF BIOMEDICAL OPTICS

The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress

(2009) You-Wei Zhang et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity

(2009) M Walker et al.   ONCOGENE

Bimolecular Fluorescence Complementation (BiFC) Analysis as a Probe of Protein Interactions in Living Cells

(2008) Tom K. Kerppola   Annual Review of Biophysics

ATRMec1Phosphorylation-independent Activation of Chk1in Vivo

(2008) Yinhuai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Chk1 by Its C-terminal Domain

(2008) Ana Kosoy et al.   MOLECULAR BIOLOGY OF THE CELL

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

(2008) D. Wilsker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA