Article
Pharmacology & Pharmacy
Todd A. Miano, Lei Wang, Charles E. Leonard, Colleen M. Brensinger, Emily K. Acton, Ghadeer K. Dawwas, Warren B. Bilker, Samantha E. Soprano, Thanh Phuong Pham Nguyen, George Woody, Elmer Yu, Mark Neuman, Lang Li, Sean Hennessy
Summary: This study performed a high-throughput screening for drug-drug interactions with methadone and buprenorphine using a combination of pharmacoepidemiologic and pharmacokinetic approaches. The results identified several statistically significant interactions, including gabapentinoids, baclofen, and benzodiazepines with either methadone or buprenorphine. Clonidine and fluconazole with buprenorphine were also found to have potential interactions. These findings provide important targets for future confirmation studies.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Adriana Manas, Kristina Aaltonen, Natalie Andersson, Karin Hansson, Aleksandra Adamska, Alexandra Seger, Hiroaki Yasui, Hilda van den Bos, Katarzyna Radke, Javanshir Esfandyari, Madhura Satish Bhave, Jenny Karlsson, Diana Spierings, Floris Foijer, David Gisselsson, Daniel Bexell
Summary: This study investigates the mechanisms of chemotherapy resistance in high-risk neuroblastoma (NB) and highlights the significance of transcriptional cell states in chemoresistance.
Article
Medicine, Research & Experimental
Libin Song, Simin Qi, Wei Hu, Zhixiao Fang, Dehua Yu, Teng Liu, Jingni Wu, Yangjun Wu, Aiwei Wu, Lanyun Feng, Jing Xie, Bo Zhang, Wenguang He, Zhouyu Ning, Luming Liu, Jiang-Jiang Qin, Shengli Li
Summary: Pancreatic cancer cell lines were classified into two subgroups based on transcriptomic mRNA expression, with distinct protein profiles and differential proteins involved in specific signaling pathways. Patients in different subgroups exhibited varying clinical outcomes and drug sensitivities, suggesting potential for precision treatments based on molecular characteristics.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Multidisciplinary Sciences
Elpida Kontsioti, Simon Maskell, Bhaskar Dutta, Munir Pirmohamed
Summary: The accurate and timely detection of adverse drug-drug interactions (DDIs) during the postmarketing phase is important. This study proposes a scalable approach for generating a reference set for DDIs by automatically extracting and aggregating information from multiple clinical resources, supporting research in postmarketing safety surveillance.
Review
Biochemistry & Molecular Biology
Mackenzie Newman, Heather Connery, Jonathan Boyd
Summary: Opioids are widely used but have side effects such as central respiratory depression. Vitamin C has been shown to reduce these effects, but the underlying mechanisms are unclear. This review provides a signaling framework for the interaction between MOR activation and vitamin C, indicating the need for further research on their crosstalk in alleviating the negative side effects of opioids.
Article
Medicine, Research & Experimental
Xuesong Liu, Ruoxi Hong, Peina Du, Di Yang, Meibo He, Qingnan Wu, Lin Li, Yan Wang, Jie Chen, Qingjie Min, Jinting Li, Weimin Zhang, Qimin Zhan
Summary: The study investigated the metabolic genomic variations in patients with esophageal squamous cell carcinoma (ESCC) and identified genetic alterations associated with metabolic pathways. They identified potential metabolic drivers and validated their role in the malignancy of ESCC. Additionally, they found genetic panels that could stratify patients into different prognostic groups based on metabolic gene alterations.
Article
Biochemistry & Molecular Biology
Li Guo, Yihao Kang, Yiqi Xiong, Lin Jia, Xiaoqiang Yan, Daoliang Xia, Jiafeng Yu, Jun Wang, Tingming Liang
Summary: This study identified key genes and RNAs associated with prostate adenocarcinoma (PRAD) and constructed a risk model that could potentially serve as a biomarker for cancer prognosis. The study also revealed potential interactions among different RNAs and surveyed the landscape of isomiRs in homologous miRNA loci. Furthermore, the study characterized TK1, miR-222-3p, and SNHG3 as crucial RNAs with correlations to poor survival outcomes.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemical Research Methods
Daniel E. Mattox, Chris Bailey-Kellogg
Summary: The study comprehensively investigates specificity-conferring features of lectin-glycan interactions and provides a novel approach for predicting the identity of bound glycans and understanding lectin specificity through systematic characterization and analysis.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Oncology
Stefan G. van Ravensteijn, Yvonne M. H. Versleijen-Jonkers, Melissa H. S. Hillebrandt-Roeffen, Marije E. Weidema, Maikel J. L. Nederkoorn, Kalijn F. Bol, Mark A. J. Gorris, Kiek Verrijp, Leonie I. Kroeze, Tessa J. J. de Bitter, Richarda M. de Voer, Uta E. Flucke, Ingrid M. E. Desar
Summary: This study investigates the immunological and genomic profiles of angiosarcomas (AS) and identifies significant differences between primary AS and secondary AS. The T-cell infiltrated tumor microenvironment and frequent DNA damage response gene mutations, especially in secondary AS, suggest the potential for immunotherapy in this subgroup.
Article
Biochemistry & Molecular Biology
Si Li, Weiwei Zhou, Donghao Li, Tao Pan, Jing Guo, Haozhe Zou, Zhanyu Tian, Kongning Li, Juan Xu, Xia Li, Yongsheng Li
Summary: This study investigates the regulatory pattern of human-virus interactions by analyzing experimentally validated protein-protein interactions (PPIs) between humans and viruses. The research reveals that viral interacting proteins are enriched in cell cycle and immune-related pathways, and tend to locate in central regions of the human PPI network. The study also uncovers associations between complex diseases and viral infections through network proximity analysis and identifies potential antiviral drugs. Additionally, the researchers have developed a Human-Virus Protein-Protein Interaction database that provides experimentally validated human-virus PPIs and functional analysis tools.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Benjamin Lang, Jae-Seong Yang, Mireia Garriga-Canut, Silvia Speroni, Moritz Aschern, Maria Gili, Tobias Hoffmann, Gian Gaetano Tartaglia, Sebastian P. Maurer
Summary: RNA-binding proteins (RBPs) play critical roles in post-transcriptional gene regulation, interacting with RNA structures to increase specificity and regulatory possibilities. RBPs form complexes through interactions in vivo, which influence RNA processing and splicing.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Oncology
Jinfeng Liu, Jian Hao, Yangyang Niu, Xiongzhi Wu
Summary: This study aimed to identify the molecular targets of effective Chinese herbs in treating stage IV lung adenocarcinoma through clinical data and network pharmacology. It found that Chinese Herbal Medicine (CHM) treatment was associated with survival benefit and identified 18 herbs beneficial to survival. The study provides a foundation for herbal research based on clinical data.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Evelyn Jiagge, Dexter X. Jin, Justin Y. Newberg, Tomin Perea-Chamblee, Kelly R. Pekala, Christopher Fong, Michele Waters, David Ma, Yvonne Dei-Adomakoh, Gilles Erb, Kanika S. Arora, Sophia L. Maund, Njoki Njiraini, Atara Ntekim, Susie Kim, Xuechun Bai, Marlene Thomas, Ronwyn van Eeden, Priti Hegde, Justin Jee, Debyani Chakravarthy, Nikolaus Schultz, Michael F. Berger, Garrett M. Frampton, Ethan S. Sokol, Jian Carrot-Zhang
Summary: This study investigates genomic alterations in cancer patients with African ancestry and identifies cross-cancer type associations as well as differences in actionable alterations. The study also highlights the impact of ancestry-environment interaction on driver rates.
Article
Food Science & Technology
Shanoo Suroowan, Hassan Hadi Abdallah, Mohamad Fawzi Mahomoodally
Summary: Herbal and conventional medicine combination can be potentially dangerous, leading to perilous herb-drug interactions and toxicity. Different plant species have different pharmacological properties, and should not be mixed with drugs having the same properties. Herbal medicines should be used at low doses for a short period of time and under the supervision of healthcare professionals to avoid potential adverse and toxic effects.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Oncology
Bo Li, Ning Pu, Qiangda Chen, Yong Mei, Dansong Wang, Dayong Jin, Wenchuan Wu, Lei Zhang, Wenhui Lou
Summary: This study established a diagnostic nomogram based on postoperative objective parameters that can predict the development of CR-POPF after PD with good discriminative ability and predictive accuracy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
John M. Streicher
MOLECULAR PHARMACOLOGY
(2019)
Article
Clinical Neurology
Wei Lei, Rakesh H. Vekariya, Subramaniam Ananthan, John M. Streicher
Article
Chemistry, Medicinal
Azzurra Stefanucci, Marilisa Pia Dimmito, Giorgia Macedonio, Laura Ciarlo, Stefano Pieretti, Ettore Novellino, Wei Lei, Deborah Barlow, Karen L. Houseknecht, John M. Streicher, Adriano Mollica
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Justin LaVigne, Attila Keresztes, Daniel Chiem, John M. Streicher
PHARMACOLOGICAL REPORTS
(2020)
Article
Chemistry, Medicinal
Azzurra Stefanucci, Marilisa Pia Dimmito, Gabriela Molnar, John M. Streicher, Ettore Novellino, Gokhan Zengin, Adriano Mollica
ACS MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Biochemistry & Molecular Biology
David Duron, Wei Lei, Natalie K. Barker, Carrie Stine, Sanket Mishra, Brian S. J. Blagg, Paul R. Langlais, John M. Streicher
Article
Behavioral Sciences
Michael M. Morgan, Danielle L. Peecher, John M. Streicher
Summary: This study evaluated a novel antagonist (D24M) of the mu-/delta-opioid receptor (MOR/DOR) heterodimer in male rats. The results showed that D24M did not have disruptive side effects and tended to prolong morphine's antinociceptive effects in non-tolerant rats. Further studies are needed to assess the effects of D24M on withdrawal to continuous morphine administration in rats with persistent pain.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Justin E. LaVigne, Ryan Hecksel, Attila Keresztes, John M. Streicher
Summary: Limited evidence suggests that terpenes found in Cannabis sativa may have cannabimimetic activity and can enhance cannabinoid activity. These multifunctional cannabimimetic ligands provide support for the entourage effect hypothesis, potentially enhancing the therapeutic properties of cannabinoids.
SCIENTIFIC REPORTS
(2021)
Article
Anesthesiology
Attila Keresztes, Keith Olson, Paul Nguyen, Marissa A. Lopez-Pier, Ryan Hecksel, Natalie K. Barker, Zekun Liu, Victor Hruby, John Konhilas, Paul R. Langlais, John M. Streicher
Summary: This study reveals a new function of opioid receptors as a negative feedback brake on opioid-induced analgesia. By using a selective antagonist for the mu and delta opioid receptors (MDOR), the researchers found that the antagonist could enhance the analgesic effect of oxymorphone in mice, suggesting a role for MDOR in regulating pain. Additionally, the study found that the enhancement effect was selective to MDOR and occurred through the repression of Src and CaMKII signal transduction. These findings suggest that MDOR antagonism could be a potential approach to improve clinical opioid therapy.
Review
Pharmacology & Pharmacy
Balazs R. Varga, John M. Streicher, Susruta Majumdar
Summary: This article discusses the current status of using opioids for pain treatment and some potential new targets that may lead to safer next generation analgesics.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Parthasaradhireddy Tanguturi, Vibha Pathak, Sixue Zhang, Omar Moukha-Chafiq, Corinne E. Augelli-Szafran, John M. Streicher
Summary: The study successfully developed novel inverse agonists and irreversible antagonists for the delta opioid receptor, providing new tools to investigate its biology or potential therapeutics.
Correction
Biochemistry & Molecular Biology
Parthasaradhireddy Tanguturi, Vibha Pathak, Sixue Zhang, Omar Moukha-Chafiq, Corinne E. Augelli-Szafran, John M. Streicher
Article
Pharmacology & Pharmacy
Jared R. Wahl, Anjali Vivek, Seph M. Palomino, Moyad Almuslim, Karissa E. Cottier, Paul R. Langlais, John M. Streicher, Todd W. Vanderah, Erika Liktor-Busa, Tally M. Largent-Milnes
Summary: This study investigates the role of cortical spreading depression (CSD) in blood-brain barrier (BBB) pathology using an in vitro model. The findings suggest that CSD can lead to relocalization and functional alteration of proteins associated with the actin cytoskeleton and endothelial tight junctions. Additionally, unique phosphorylation signatures were identified in phospho-proteomic analysis, highlighting Zona Occludins 1 (ZO-1) as a potential pathologic checkpoint of the BBB.
Article
Pharmacology & Pharmacy
Seph M. Palomino, Aidan A. Levine, Jared Wahl, Erika Liktor-Busa, John M. Streicher, Tally M. Largent-Milnes
Summary: This study investigated the role of heat shock protein HSP90 in blood-brain barrier leak associated with cortical spreading depression (CSD). The results showed that inhibition of HSP90 reduced CSD-induced blood-brain barrier leak, suggesting a potential therapeutic approach for headache disorders targeting HSP90.
Article
Biochemistry & Molecular Biology
Katherin A. Gabriel, John M. Streicher
Summary: Opioids are effective for acute pain but chronic use leads to tolerance. Inhibiting the chaperone protein HSP90 increases the antinociceptive effects of opioids by activating the kinase ERK. This activation is mediated by the relief of a negative feedback loop involving the kinase AMPK.