Review
Chemistry, Medicinal
Komal Gupta, Pooja A. Chawla, Deepika Sharma
Summary: NSAIDs have beneficial properties but are associated with various side effects, which can be effectively curbed using the prodrug approach. Many synthesis strategies focus on creating drugs that are devoid of undesired side effects.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Review
Obstetrics & Gynecology
Kamran Hessami, Jennifer Welch, Anja Frost, Abdelrahman AlAshqar, Sara E. Arian, Ethan Gough, Mostafa A. Borahay
Summary: In this meta-analysis, we examined the quantity and dose of opioids dispensed during the perioperative period for benign hysterectomy, as well as the predictors of persistent opioid use after the procedure. A total of 8 studies involving 377,569 women were included. The findings showed that 83% of women were dispensed opioids during the perioperative period, and the rate of persistent opioid use after benign hysterectomy was 5%.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Anesthesiology
Daniel B. Larach, Jennifer F. Waljee, Mark C. Bicket, Chad M. Brummett, Stephen Bruehl
Summary: This article reviews the connection between perioperative opioid prescribing and postoperative OUD and overdose, and summarizes the existing evidence. The identified risk factors are mainly related to opioid use and demographic attributes.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Review
Urology & Nephrology
Kevin M. Carnes, Zorawar Singh, Ashar Ata, Badar M. Mian
Summary: This study evaluated the effectiveness of interventions in reducing opioid prescriptions after urological surgery. The research found that direct interventions were more effective in reducing opioid prescriptions, leading to a significant decrease in opioid consumption by patients.
JOURNAL OF UROLOGY
(2022)
Article
Surgery
Kevin K. Zhang, Kevin M. Blum, Jacqueline J. Chu, Abeba Zewdu, Sarah Janse, Roman Skoracki, Jeffrey E. Janis, Jenny C. Barker
Summary: This study tested the efficacy of a patient-specific opioid prescribing framework for estimating postdischarge opioid consumption and found that it accurately estimates opioid need and risk of persistent use in plastic surgery patients.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Review
Pharmacology & Pharmacy
Eric M. Kinney, Sandhya Vijapurapu, Jordan R. Covvey, Branden D. Nemecek
Summary: The concurrent use of opioids and rifamycins may lead to decreased analgesic effects, prompting further research on specific mitigation strategies.
Review
Clinical Neurology
Kanishka Rajput, Sukhman Shergill, Robert M. Chow, Nalini Vadivelu, Alan David Kaye
Summary: Many surgical subspecialties have developed ERAS protocols focusing on multimodal analgesia to limit opioid use during hospital stay. However, there is a lack of research on non-opioid strategies for postoperative pain management after discharge. Studies trying to reduce opioid overprescription might lead to inadequate pain control, highlighting the need for further research on non-opioid therapies.
CURRENT PAIN AND HEADACHE REPORTS
(2022)
Review
Anesthesiology
Celeste A. Mallama, Christina Greene, Apostolos A. Alexandridis, Jana K. McAninch, Gerald Dal Pan, Tamra Meyer
Summary: The use of outpatient opioid analgesics reported by patients after surgery varies widely across different types of procedures, with knee and hip arthroplasty showing the highest usage. Many procedures resulted in reported usage of less than 5 tablets.
Review
Anesthesiology
Kuo-Chuan Hung, Po-Chih Chang, Chih-Wei Hsu, Kuo-Mao Lan, Shu-Wei Liao, Yao-Tsung Lin, Ping-Wen Huang, Cheuk-Kwan Sun
Summary: This study aimed to investigate the effectiveness of using Analgesia Nociception Index (ANI) to guide opioid administration during surgery under general anesthesia. A systematic review and meta-analysis of six studies were conducted, which indicated that using ANI did not reduce intraoperative opioid administration compared to conventional clinical measurements. However, it showed potential effectiveness in reducing opioid administration in female patients. Further research is needed to support these findings.
MINERVA ANESTESIOLOGICA
(2023)
Review
Anesthesiology
Kevin Gorsky, Nick D. Black, Ayan Niazi, Aparna Saripella, Marina Englesakis, Timothy Leroux, Frances Chung, Ahtsham U. Niazi
Summary: Psychological interventions, including relaxation, psychoeducation, and behavioral modification therapy, have shown promise in reducing postoperative opioid use and pain scores. However, further research is needed to strengthen the evidence for these interventions and determine optimal techniques, timing, and strategies.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Keith M. Olson, Andrea L. Devereaux, Payal Chatterjee, Savanah L. Saldana-Shumaker, Amanda Shafer, Adam Plotkin, Ram Kandasamy, Alexander D. MacKerell, John R. Traynor, Christopher W. Cunningham
Summary: This study investigates the structure-activity relationships of benzylideneoxymorphone analogs in order to develop analgesics with reduced tolerance and side effects. One compound, nitro-BOM (NBOM), showed high-efficacy antinociception but also exhibited tolerance and toxicity upon repeated administration. Despite these issues, NBOM provides an important tool for understanding MOPr/DOPr pharmacology.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Otorhinolaryngology
Peter K. Moon, Eric X. Wei, Marzan S. Hamid, John A. Borghi, Uchechukwu C. Megwalu
Summary: This study aimed to compare the pain outcomes between nonopioid analgesic regimens and opioid analgesic regimens after thyroid and parathyroid surgery. The results showed that there were no significant differences in postoperative pain scores between the two regimens. Therefore, nonopioid analgesic regimens are recommended to reduce the risk of opioid dependence associated with prescription opioids.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Review
Engineering, Aerospace
Frederico Afonso, Martin Sohst, Carlos M. A. Diogo, Simao S. Rodrigues, Ana Ferreira, Ines Ribeiro, Ricardo Marques, Francisco F. C. Rego, Abdolrasoul Sohouli, Joana Portugal-Pereira, Hugo Policarpo, Bruno Soares, Bruna Ferreira, Edgar C. Fernandes, Fernando Lau, Afzal Suleman
Summary: As climate change worsens and resources continue to be depleted, the importance of sustainable industries, including aviation, becomes even more crucial. Although current carbon dioxide emissions from aviation only account for 2%-4%, future projections indicate significant annual growth, making it necessary to find ways to reduce emissions through renewable energy use. However, the aviation industry faces challenges due to the need for efficient and lightweight energy storage systems, as battery technology falls short of fossil fuel energy densities and is not environmentally friendly to produce. Therefore, an integrated effort is required to implement various mitigation strategies. This paper reviews and categorizes the most innovative solutions for greener aviation, covering concepts of operations, energy storage, propulsion systems, aerodynamics, structures, materials, and manufacturing processes. Additionally, potential synergies between different technologies are proposed to achieve green aviation.
PROGRESS IN AEROSPACE SCIENCES
(2023)
Review
Green & Sustainable Science & Technology
Shan Hu, Xin Zhou, Da Yan, Fei Guo, Tianzhen Hong, Yi Jiang
Summary: Building Energy Sufficiency (BES) is gaining attention as an important framework for reducing energy use and carbon emissions in buildings. However, there is a lack of research on the drivers, technologies, and policy instruments needed to achieve BES during the building operational phase. This study provides a systematic review of BES and suggests that it should address both occupant demand and energy requirements. The characteristics of occupant demand and technical options for building systems are discussed, along with policy implications and recommendations. Further research and policy implementation in both developed and developing countries are justified due to the multiple benefits and multidisciplinary nature of BES.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
Article
Medicine, General & Internal
Deanne E. Jenkin, Justine M. Naylor, Joseph Descallar, Ian A. Harris
Summary: This study found that treatment with strong opioid medication subacutely was not superior to treatment with milder medication for the management of pain in surgically managed orthopedic fracture patients. Therefore, ongoing first-line strong opioid use after discharge from the hospital should not be supported.
Article
Chemistry, Medicinal
Azzurra Stefanucci, Marilisa Pia Dimmito, Giorgia Macedonio, Laura Ciarlo, Stefano Pieretti, Ettore Novellino, Wei Lei, Deborah Barlow, Karen L. Houseknecht, John M. Streicher, Adriano Mollica
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Cell Biology
Steven G. Grinnell, Rajendra Uprety, Andras Varadi, Joan Subrath, Amanda Hunkele, Ying Xian Pan, Gavril W. Pasternak, Susruta Majumdar
Summary: Mu opioid receptors (MOR-1) play a crucial role in the biological effects of clinically used opioids, with the OPRM1 gene generating multiple splice variants including 6TM variants associated with the analgesic effects of novel opioids. IBNtxA has been identified as a potent analgesic with reduced side effects compared to traditional opiates, and can be used to photolabel mouse mu opioid receptors for further investigation into ligand-protein contacts and signaling complexes.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
David Duron, Wei Lei, Natalie K. Barker, Carrie Stine, Sanket Mishra, Brian S. J. Blagg, Paul R. Langlais, John M. Streicher
Article
Biochemistry & Molecular Biology
Soumen Chakraborty, Susruta Majumdar
Summary: Pain management has been a significant issue in medicine, with efforts focused on developing alternative opioids without side effects.
Article
Behavioral Sciences
Michael M. Morgan, Danielle L. Peecher, John M. Streicher
Summary: This study evaluated a novel antagonist (D24M) of the mu-/delta-opioid receptor (MOR/DOR) heterodimer in male rats. The results showed that D24M did not have disruptive side effects and tended to prolong morphine's antinociceptive effects in non-tolerant rats. Further studies are needed to assess the effects of D24M on withdrawal to continuous morphine administration in rats with persistent pain.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Cell Biology
Lisa L. Wilson, Soumen Chakraborty, Shainnel O. Eans, Thomas J. Cirino, Heather M. Stacy, Chloe A. Simons, Rajendra Uprety, Susruta Majumdar, Jay P. McLaughlin
Summary: The study confirmed the medicinal value of Thai traditional tea kratom, showing that kratom and its alkaloids can reduce dependence on opioids and alleviate withdrawal symptoms.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Justin E. LaVigne, Ryan Hecksel, Attila Keresztes, John M. Streicher
Summary: Limited evidence suggests that terpenes found in Cannabis sativa may have cannabimimetic activity and can enhance cannabinoid activity. These multifunctional cannabimimetic ligands provide support for the entourage effect hypothesis, potentially enhancing the therapeutic properties of cannabinoids.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Parthasaradhireddy Tanguturi, Vibha Pathak, Sixue Zhang, Omar Moukha-Chafiq, Corinne E. Augelli-Szafran, John M. Streicher
Summary: The study successfully developed novel inverse agonists and irreversible antagonists for the delta opioid receptor, providing new tools to investigate its biology or potential therapeutics.
Review
Biochemistry & Molecular Biology
Shan Liu, Wen-Jia Kang, Anna Abrimian, Jin Xu, Luca Cartegni, Susruta Majumdar, Patrick Hesketh, Alex Bekker, Ying-Xian Pan
Summary: The OPRM1 gene undergoes extensive alternative splicing to produce multiple splice variants with important pharmacological implications for the actions of opioid drugs. These variants can mediate distinct effects of various mu opioids and be targeted for the development of novel analgesics with potent efficacy against multiple types of pain while reducing side effects associated with traditional opiates.
Correction
Biochemistry & Molecular Biology
Parthasaradhireddy Tanguturi, Vibha Pathak, Sixue Zhang, Omar Moukha-Chafiq, Corinne E. Augelli-Szafran, John M. Streicher
Article
Pharmacology & Pharmacy
Jared R. Wahl, Anjali Vivek, Seph M. Palomino, Moyad Almuslim, Karissa E. Cottier, Paul R. Langlais, John M. Streicher, Todd W. Vanderah, Erika Liktor-Busa, Tally M. Largent-Milnes
Summary: This study investigates the role of cortical spreading depression (CSD) in blood-brain barrier (BBB) pathology using an in vitro model. The findings suggest that CSD can lead to relocalization and functional alteration of proteins associated with the actin cytoskeleton and endothelial tight junctions. Additionally, unique phosphorylation signatures were identified in phospho-proteomic analysis, highlighting Zona Occludins 1 (ZO-1) as a potential pathologic checkpoint of the BBB.
Article
Pharmacology & Pharmacy
Seph M. Palomino, Aidan A. Levine, Jared Wahl, Erika Liktor-Busa, John M. Streicher, Tally M. Largent-Milnes
Summary: This study investigated the role of heat shock protein HSP90 in blood-brain barrier leak associated with cortical spreading depression (CSD). The results showed that inhibition of HSP90 reduced CSD-induced blood-brain barrier leak, suggesting a potential therapeutic approach for headache disorders targeting HSP90.
Article
Biochemistry & Molecular Biology
Katherin A. Gabriel, John M. Streicher
Summary: Opioids are effective for acute pain but chronic use leads to tolerance. Inhibiting the chaperone protein HSP90 increases the antinociceptive effects of opioids by activating the kinase ERK. This activation is mediated by the relief of a negative feedback loop involving the kinase AMPK.
