Metabolons in plant primary and secondary metabolism

Analyses of starch biosynthetic protein complexes and starch properties from developing mutant rice seeds with minimal starch synthase activities

(2018) Mari Hayashi et al.   BMC PLANT BIOLOGY

Strategies for microbial synthesis of high-value phytochemicals

(2018) Sijin Li et al.   Nature Chemistry

Physical interactions among flavonoid enzymes in snapdragon and torenia reveal the diversity in the flavonoid metabolon organization of different plant species

(2018) Naoto Fujino et al.   PLANT JOURNAL

Involvement of chalcone reductase (CHR) in the soybean isoflavone metabolon: Identification of GmCHR5 that interacts with 2-hydroxyisoflavanone synthase

(2018) Ryo Mameda et al.   PLANT JOURNAL

The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions

(2018) Youjun Zhang et al.   PLANT PHYSIOLOGY

Noncatalytic chalcone isomerase-fold proteins inHumulus lupulusare auxiliary components in prenylated flavonoid biosynthesis

(2018) Zhaonan Ban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Components of the Lignin Biosynthetic Metabolon

(2018) Juan Du et al.   TRENDS IN PLANT SCIENCE

The role of dynamic enzyme assemblies and substrate channelling in metabolic regulation

(2018) Lee J. Sweetlove et al.   Nature Communications

First evidence for a multienzyme complex of lipid biosynthesis pathway enzymes in Cunninghamella bainieri

(2018) Shuwahida Shuib et al.   Scientific Reports

Anthocyanin Biosynthesis and Degradation Mechanisms in Solanaceous Vegetables: A Review

(2018) Ying Liu et al.   Frontiers in Chemistry

Cytosolic GAPDH as a redox-dependent regulator of energy metabolism

(2018) Markus Schneider et al.   BMC PLANT BIOLOGY

Enzyme fusion removes competition for geranylgeranyl diphosphate in carotenogenesis

(2018) Maurizio Camagna et al.   PLANT PHYSIOLOGY

Engineering of metabolic pathways using synthetic enzyme complexes

(2018) Nicholas Smirnoff   PLANT PHYSIOLOGY

Glucose-6-phosphate dehydrogenase and Trypanothione reductase interaction protects Leishmania donovani from metalloid mediated oxidative stress

(2017) Ayan Kumar Ghosh et al.   FREE RADICAL BIOLOGY AND MEDICINE

The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer

(2017) Izumi Yanatori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tat proteins as novel thylakoid membrane anchors organize a biosynthetic pathway in chloroplasts and increase product yield 5-fold

(2017) Maria Perestrello Ramos Henriques de Jesus et al.   METABOLIC ENGINEERING

Capturing protein communities by structural proteomics in a thermophilic eukaryote

(2017) Panagiotis L Kastritis et al.   Molecular Systems Biology

Photosynthetic fuel for heterologous enzymes: the role of electron carrier proteins

(2017) Silas Busck Mellor et al.   PHOTOSYNTHESIS RESEARCH

Cutinsomes as building-blocks of Arabidopsis thaliana embryo cuticle

(2017) Dariusz Stępiński et al.   PHYSIOLOGIA PLANTARUM

How to prove the existence of metabolons?

(2017) Jean-Etienne Bassard et al.   PHYTOCHEMISTRY REVIEWS

Plastidial α-glucan phosphorylase 1 complexes with disproportionating enzyme 1 in Ipomoea batatas storage roots for elevating malto-oligosaccharide metabolism

(2017) Yi-Chen Lin et al.   PLoS One

A New View into the Regulation of Purine Metabolism: The Purinosome

(2017) Anthony M. Pedley et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein-protein interactions and metabolite channelling in the plant tricarboxylic acid cycle

(2017) Youjun Zhang et al.   Nature Communications

Synthetic Protein Scaffolds for Biosynthetic Pathway Colocalization on Lipid Droplet Membranes

(2017) Jyun-Liang Lin et al.   ACS Synthetic Biology

Directional Regulation of Enzyme Pathways through the Control of Substrate Channeling on a DNA Origami Scaffold

(2016) Guoliang Ke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of protein–protein interactions of isoflavonoid biosynthetic enzymes with 2-hydroxyisoflavanone synthase in soybean (Glycine max (L.) Merr.)

(2016) Toshiyuki Waki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rice Endosperm Starch Phosphorylase (Pho1) Assembles with Disproportionating Enzyme (Dpe1) to Form a Protein Complex That Enhances Synthesis of Malto-oligosaccharides

(2016) Seon-Kap Hwang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the metabolic interactions of (photo)respiration

(2016) Toshihiro Obata et al.   JOURNAL OF EXPERIMENTAL BOTANY

Localization and interactions between Arabidopsis auxin biosynthetic enzymes in the TAA/YUC-dependent pathway

(2016) Verena Kriechbaumer et al.   JOURNAL OF EXPERIMENTAL BOTANY

Substrate channelling as an approach to cascade reactions

(2016) Ian Wheeldon et al.   Nature Chemistry

Fine-tuning of microsolvation and hydrogen bond interaction regulates substrate channelling in the course of flavonoid biosynthesis

(2016) Julien Diharce et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Regulation of plant secondary metabolism and associated specialized cell development by MYBs and bHLHs

(2016) William R. Chezem et al.   PHYTOCHEMISTRY

Heterodimer Formation of BnPKSA or BnPKSB with BnACOS5 Constitutes a Multienzyme Complex in Tapetal Cells and is Involved in Male Reproductive Development inBrassica napus

(2016) Maomao Qin et al.   PLANT AND CELL PHYSIOLOGY

Lighting the Way to Protein-Protein Interactions: Recommendations on Best Practices for Bimolecular Fluorescence Complementation Analyses

(2016) Jörg Kudla et al.   PLANT CELL

Twin anchors of the soybean isoflavonoid metabolon: evidence for tethering of the complex to the endoplasmic reticulum by IFS and C4H

(2016) Mehran Dastmalchi et al.   PLANT JOURNAL

Techniques for the analysis of protein-protein interactions in vivo

(2016) Shuping Xing et al.   PLANT PHYSIOLOGY

Spatial colocalization and functional link of purinosomes with mitochondria

(2016) J. B. French et al.   SCIENCE

Plant metabolons assembled on demand

(2016) Mehran Dastmalchi et al.   SCIENCE

Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum

(2016) Tomas Laursen et al.   SCIENCE

Cytosolic thiol switches regulating basic cellular functions: GAPDH as an information hub?

(2015) Thomas Hildebrandt et al.   BIOLOGICAL CHEMISTRY

Unlocking the Diversity of Alkaloids in Catharanthus roseus: Nuclear Localization Suggests Metabolic Channeling in Secondary Metabolism

(2015) Anna Stavrinides et al.   CHEMISTRY & BIOLOGY

Synthetic scaffolds for pathway enhancement

(2015) Ka-Hei Siu et al.   CURRENT OPINION IN BIOTECHNOLOGY

Amylopectin biosynthetic enzymes from developing rice seed form enzymatically active protein complexes

(2015) Naoko Crofts et al.   JOURNAL OF EXPERIMENTAL BOTANY

The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally

(2015) Winnie Luu et al.   JOURNAL OF LIPID RESEARCH

The biosynthesis, composition and assembly of the outer pollen wall: A tough case to crack

(2015) Teagen D. Quilichini et al.   PHYTOCHEMISTRY

A Heteromeric Membrane-Bound Prenyltransferase Complex from Hop Catalyzes Three Sequential Aromatic Prenylations in the Bitter Acid Pathway

(2015) Haoxun Li et al.   PLANT PHYSIOLOGY

Comprehensive Assessment of Transcriptional Regulation Facilitates Metabolic Engineering of Isoprenoid Accumulation in Arabidopsis

(2015) Iris Lange et al.   PLANT PHYSIOLOGY

Protein–protein interactions among enzymes of starch biosynthesis in high-amylose barley genotypes reveal differential roles of heteromeric enzyme complexes in the synthesis of A and B granules

(2015) Zaheer Ahmed et al.   PLANT SCIENCE

Substrate channeling between the human dihydrofolate reductase and thymidylate synthase

(2015) Nuo Wang et al.   PROTEIN SCIENCE

Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein

(2015) T. Winzer et al.   SCIENCE

Plasticity of specialized metabolism as mediated by dynamic metabolons

(2015) Tomas Laursen et al.   TRENDS IN PLANT SCIENCE

Cyanogenic Glycosides: Synthesis, Physiology, and Phenotypic Plasticity

(2014) Roslyn M. Gleadow et al.   Annual Review of Plant Biology

First Evidence for Substrate Channeling between Proline Catabolic Enzymes

(2014) Nikhilesh Sanyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Multiple Phosphorylation Sites on Maize Endosperm Starch Branching Enzyme IIb, a Key Enzyme in Amylopectin Biosynthesis

(2014) Amina Makhmoudova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipotubuloids in ovary epidermis of Ornithogalum umbellatum act as metabolons: suggestion of the name ‘lipotubuloid metabolon’

(2014) Maria Kwiatkowska et al.   JOURNAL OF EXPERIMENTAL BOTANY

CYP83A1 is required for metabolic compatibility of Arabidopsis with the adapted powdery mildew fungusErysiphe cruciferarum

(2014) Corina Weis et al.   NEW PHYTOLOGIST

Regulation of Specialized Metabolism by WRKY Transcription Factors

(2014) Craig Schluttenhofer et al.   PLANT PHYSIOLOGY

Pathway Thermodynamics Highlights Kinetic Obstacles in Central Metabolism

(2014) Elad Noor et al.   PLoS Computational Biology

The Spatial Organization of Metabolism Within the Plant Cell

(2013) Lee J. Sweetlove et al.   Annual Review of Plant Biology

Transcriptional regulation of secondary metabolite biosynthesis in plants

(2013) Barunava Patra et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Revisiting and revising the purinosome

(2013) Alice Zhao et al.   Molecular BioSystems

Co-immunoprecipitation-based identification of putative BAX INHIBITOR-1-interacting proteins involved in cell death regulation and plant-powdery mildew interactions

(2013) Corina Weis et al.   MOLECULAR PLANT PATHOLOGY

Sporopollenin Biosynthetic Enzymes Interact and Constitute a Metabolon Localized to the Endoplasmic Reticulum of Tapetum Cells

(2013) B. Lallemand et al.   PLANT PHYSIOLOGY

Evolutionary Origin of the Mitochondrial Cholesterol Transport Machinery Reveals a Universal Mechanism of Steroid Hormone Biosynthesis in Animals

(2013) Jinjiang Fan et al.   PLoS One

Redirecting Photosynthetic Reducing Power toward Bioactive Natural Product Synthesis

(2013) Agnieszka Zygadlo Nielsen et al.   ACS Synthetic Biology

Permeability of the peroxisomal membrane: lessons from the glyoxylate cycle

(2013) Markus Kunze et al.   Frontiers in Physiology

Protein-Protein and Protein-Membrane Associations in the Lignin Pathway

(2012) J.-E. Bassard et al.   PLANT CELL

Bacterial- and plant-type phosphoenolpyruvate carboxylase isozymes from developing castor oil seeds interact in vivo and associate with the surface of mitochondria

(2012) Joonho Park et al.   PLANT JOURNAL

Insight on an Arginine Synthesis Metabolon from the Tetrameric Structure of Yeast Acetylglutamate Kinase

(2012) Sergio de Cima et al.   PLoS One

Functional Analysis of Metabolic Channeling and Regulation in Lignin Biosynthesis: A Computational Approach

(2012) Yun Lee et al.   PLoS Computational Biology

An intramolecular transport metabolon: fusion of carbonic anhydrase II to the COOH terminus of the Cl−/HCO3− exchanger, AE1

(2011) Daniel Sowah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Bax inhibitor-1: a highly conserved endoplasmic reticulum-resident cell death suppressor

(2011) T Ishikawa et al.   CELL DEATH AND DIFFERENTIATION

Förster resonance energy transfer demonstrates a flavonoid metabolon in living plant cells that displays competitive interactions between enzymes

(2011) Kevin C. Crosby et al.   FEBS LETTERS

Auxin Biosynthesis: A Simple Two-Step Pathway Converts Tryptophan to Indole-3-Acetic Acid in Plants

(2011) Yunde Zhao   Molecular Plant

Glutamate dehydrogenase in brain mitochondria: Do lipid modifications and transient metabolon formation influence enzyme activity?

(2011) Mary C. McKenna   NEUROCHEMISTRY INTERNATIONAL

Homology modeling of the three membrane proteins of the dhurrin metabolon: Catalytic sites, membrane surface association and protein–protein interactions

(2011) Kenneth Jensen et al.   PHYTOCHEMISTRY

Genetic and metabolic engineering of isoflavonoid biosynthesis

(2010) Hai Du et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Dynamic Regulation of a Metabolic Multi-enzyme Complex by Protein Kinase CK2

(2010) Songon An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical interactions between tricarboxylic acid cycle enzymes in Bacillus subtilis: Evidence for a metabolon

(2010) Frederik M. Meyer et al.   METABOLIC ENGINEERING

Alteration of mitochondrial protein complexes in relation to metabolic regulation under short-term oxidative stress in Arabidopsis seedlings

(2010) Toshihiro Obata et al.   PHYTOCHEMISTRY

Lignin Biosynthesis and Structure

(2010) R. Vanholme et al.   PLANT PHYSIOLOGY

Dynamic Metabolons

(2010) B. L. Moller   SCIENCE

The amylose extender mutant of maize conditions novel protein-protein interactions between starch biosynthetic enzymes in amyloplasts

(2009) F. Liu et al.   JOURNAL OF EXPERIMENTAL BOTANY

Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds

(2009) Marjan Van Cleemput et al.   JOURNAL OF NATURAL PRODUCTS

Synthetic protein scaffolds provide modular control over metabolic flux

(2009) John E Dueber et al.   NATURE BIOTECHNOLOGY

Tryptophan-dependent indole-3-acetic acid biosynthesis by ‘IAA-synthase’ proceeds via indole-3-acetamide

(2009) Stephan Pollmann et al.   PHYTOCHEMISTRY

Proteins from Multiple Metabolic Pathways Associate with Starch Biosynthetic Enzymes in High Molecular Weight Complexes: A Model for Regulation of Carbon Allocation in Maize Amyloplasts

(2009) T. A. Hennen-Bierwagen et al.   PLANT PHYSIOLOGY

Effects of oximes on mitochondrial oxidase activity

(2009) Koichi Sakurada et al.   TOXICOLOGY LETTERS

Alkaloid Biosynthesis: Metabolism and Trafficking

(2008) Jörg Ziegler et al.   Annual Review of Plant Biology

Analysis of Protein Complexes in Wheat Amyloplasts Reveals Functional Interactions among Starch Biosynthetic Enzymes

(2008) I. J. Tetlow et al.   PLANT PHYSIOLOGY

Starch Biosynthetic Enzymes from Developing Maize Endosperm Associate in Multisubunit Complexes

(2008) T. A. Hennen-Bierwagen et al.   PLANT PHYSIOLOGY

Functional Analysis of a Predicted Flavonol Synthase Gene Family in Arabidopsis

(2008) D. K. Owens et al.   PLANT PHYSIOLOGY

Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells

(2008) S. An et al.   SCIENCE

Metabolon formation in dhurrin biosynthesis

(2007) Kirsten Annette Nielsen et al.   PHYTOCHEMISTRY