Noncatalytic chalcone isomerase-fold proteins inHumulus lupulusare auxiliary components in prenylated flavonoid biosynthesis

Identification of chalcone isomerase in the basal land plants reveals an ancient evolution of enzymatic cyclization activity for synthesis of flavonoids

(2017) Ai-Xia Cheng et al.   NEW PHYTOLOGIST

A Proteolytic Regulator Controlling Chalcone Synthase Stability and Flavonoid Biosynthesis in Arabidopsis

(2017) Xuebin Zhang et al.   PLANT CELL

In vitro assays in natural products research – a matter of concentration and relevance to in vivo administration using resveratrol, α-mangostin/γ-mangostin and xanthohumol as examples

(2016) C. M. Willson et al.   NATURAL PRODUCT RESEARCH

Xanthohumol Induces Growth Inhibition and Apoptosis in Ca Ski Human Cervical Cancer Cells

(2015) Wai Kuan Yong et al.   Evidence-based Complementary and Alternative Medicine

Role of a chalcone isomerase-like protein in flavonoid biosynthesis inArabidopsis thaliana

(2015) Wenbo Jiang et al.   JOURNAL OF EXPERIMENTAL BOTANY

A Heteromeric Membrane-Bound Prenyltransferase Complex from Hop Catalyzes Three Sequential Aromatic Prenylations in the Bitter Acid Pathway

(2015) Haoxun Li et al.   PLANT PHYSIOLOGY

A chalcone isomerase-like protein enhances flavonoid production and flower pigmentation

(2014) Yasumasa Morita et al.   PLANT JOURNAL

Xanthohumol suppresses oestrogen-signalling in breast cancer through the inhibition of BIG3-PHB2 interactions

(2014) Tetsuro Yoshimaru et al.   Scientific Reports

Characterization of the Formation of Branched Short-Chain Fatty Acid:CoAs for Bitter Acid Biosynthesis in Hop Glandular Trichomes

(2013) Haiyang Xu et al.   Molecular Plant

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis

(2012) Micheline N. Ngaki et al.   NATURE

Tetrahydro iso-Alpha Acids from Hops Improve Glucose Homeostasis and Reduce Body Weight Gain and Metabolic Endotoxemia in High-Fat Diet-Fed Mice

(2012) Amandine Everard et al.   PLoS One

Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides

(2012) S. J. Gagne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HlPT-1, a membrane-bound prenyltransferase responsible for the biosynthesis of bitter acids in hops

(2011) Yusuke Tsurumaru et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hop bitter acids exhibit anti-fibrogenic effects on hepatic stellate cells in vitro

(2011) Michael Saugspier et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases

(2010) Ikuro Abe et al.   NATURAL PRODUCT REPORTS

The origin and evolution of lignin biosynthesis

(2010) Jing-Ke Weng et al.   NEW PHYTOLOGIST

Biomimetic Synthesis of Polycyclic Polyprenylated Acylphloroglucinol Natural Products Isolated fromHypericum papuanum

(2010) Jonathan H. George et al.   ORGANIC LETTERS

Isohumulones, the bitter component of beer, improve hyperglycemia and decrease body fat in Japanese subjects with prediabetes

(2009) Kuniaki Obara et al.   CLINICAL NUTRITION

Antioxidant Effects of Xanthohumol and Functional Impact on Hepatic Ischemia−Reperfusion Injury

(2009) Andreas Hartkorn et al.   JOURNAL OF NATURAL PRODUCTS

Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds

(2009) Marjan Van Cleemput et al.   JOURNAL OF NATURAL PRODUCTS

TrichOME: A Comparative Omics Database for Plant Trichomes

(2009) X. Dai et al.   PLANT PHYSIOLOGY

Heterodimeric geranyl(geranyl)diphosphate synthase from hop (Humulus lupulus) and the evolution of monoterpene biosynthesis

(2009) G. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacognostic and pharmacological profile of Humulus lupulus L.

(2008) Paola Zanoli et al.   JOURNAL OF ETHNOPHARMACOLOGY

Divergent evolution of the thiolase superfamily and chalcone synthase family

(2008) C JIANG et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

EST Analysis of Hop Glandular Trichomes Identifies an O-Methyltransferase That Catalyzes the Biosynthesis of Xanthohumol

(2008) J. Nagel et al.   PLANT CELL

Terpene Biosynthesis in Glandular Trichomes of Hop

(2008) G. Wang et al.   PLANT PHYSIOLOGY