SILK studies — capturing the turnover of proteins linked to neurodegenerative diseases

Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics

(2018) Brendan P. Lucey et al.   ANNALS OF NEUROLOGY

Tau Kinetics in Neurons and the Human Central Nervous System

(2018) Chihiro Sato et al.   NEURON

Amyloid-β Plaques in Clinical Alzheimer’s Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity

(2018) Norelle C. Wildburger et al.   Frontiers in Neurology

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

Protein production is an early biomarker for RNA ‐targeted therapies

(2018) Wade K. Self et al.   Annals of Clinical and Translational Neurology

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

(2016) Marc Suárez‐Calvet et al.   EMBO Molecular Medicine

Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma

(2016) Alaina T. Baker-Nigh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Historical and contemporary stable isotope tracer approaches to studying mammalian protein metabolism

(2016) Daniel James Wilkinson   MASS SPECTROMETRY REVIEWS

Late Breaker News

(2016)   Multiple Sclerosis Journal

Late Breaker News

(2016)   Multiple Sclerosis Journal

Age and amyloid effects on human central nervous system amyloid-beta kinetics

(2015) Bruce W. Patterson et al.   ANNALS OF NEUROLOGY

In vivo kinetic approach reveals slow SOD1 turnover in the CNS

(2015) Matthew J. Crisp et al.   JOURNAL OF CLINICAL INVESTIGATION

Stable Isotope Labeling by Amino acidin Vivo(SILAV): a new method to explore protein metabolism

(2015) Sylvain Lehmann et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer’s disease

(2015) Ibrahim González-Marrero et al.   Frontiers in Cellular Neuroscience

Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer’s disease patients and healthy controls

(2015) Hlin Kvartsberg et al.   Alzheimers Research & Therapy

Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer’s disease

(2015) Konstantin Hellwig et al.   Alzheimers Research & Therapy

Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease

(2015) Maartje I. Kester et al.   JAMA Neurology

Amyloid-β efflux from the central nervous system into the plasma

(2014) Kaleigh Filisa Roberts et al.   ANNALS OF NEUROLOGY

CNS Amyloid- , Soluble APP-  and -  Kinetics during BACE Inhibition

(2014) J. A. Dobrowolska et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β diurnal pattern: possible role of sleep in Alzheimer's disease pathogenesis

(2014) Brendan P. Lucey et al.   NEUROBIOLOGY OF AGING

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Increased in Vivo Amyloid- 42 Production, Exchange, and Loss in Presenilin Mutation Carriers

(2013) R. Potter et al.   Science Translational Medicine

Cerebrovascular Effects of Apolipoprotein E

(2013) Berislav V. Zlokovic   JAMA Neurology

Extracellular Tau Levels Are Influenced by Variability in Tau That Is Associated with Tauopathies

(2012) Celeste M. Karch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

(2012) Jacob M Basak et al.   Molecular Neurodegeneration

In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS

(2012) Kristin R. Wildsmith et al.   PLoS One

Effects of Age and Amyloid Deposition on Aβ Dynamics in the Human Central Nervous System

(2011) Yafei Huang   ARCHIVES OF NEUROLOGY

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Acute  -Secretase Inhibition of Nonhuman Primate CNS Shifts Amyloid Precursor Protein (APP) Metabolism from Amyloid-  Production to Alternative APP Fragments without Amyloid-  Rebound

(2010) J. J. Cook et al.   JOURNAL OF NEUROSCIENCE

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

(2010) Kaj Blennow et al.   Nature Reviews Neurology

Establishing the Proteome of Normal Human Cerebrospinal Fluid

(2010) Steven E. Schutzer et al.   PLoS One

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

A γ-secretase inhibitor decreases amyloid-β production in the central nervous system

(2009) Randall J. Bateman et al.   ANNALS OF NEUROLOGY

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE