Historical and contemporary stable isotope tracer approaches to studying mammalian protein metabolism

Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise

(2015) M. S. Brook et al.   Acta Physiologica

Application of deuterium oxide (D2O) to metabolic research: just D2O it? Depends just how you D2O it!

(2015) Daniel J. Wilkinson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Reply to letter to the editor: to D2O or not to D2O? What are the reasons we D2O it at all?

(2015) James D. Fluckey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women at rest and after exercise

(2015) Syed S. I. Bukhari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Tracer-based assessments of hepatic anaplerotic and TCA cycle flux: practicality, stoichiometry, and hidden assumptions

(2015) Stephen F. Previs et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Tracer-based estimates of protein flux in cases of incomplete product renewal: evidence and implications of heterogeneity in collagen turnover

(2015) Haihong Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Application of high-resolution mass spectrometry to measure low abundance isotope enrichment in individual muscle proteins

(2015) Kelly M. Hines et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Measurement of 15N enrichment of glutamine and urea cycle amino acids derivatized with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate using liquid chromatography–tandem quadrupole mass spectrometry

(2015) Hidehiro Nakamura et al.   ANALYTICAL BIOCHEMISTRY

Evolution of Orbitrap Mass Spectrometry Instrumentation

(2015) Shannon Eliuk et al.   Annual Review of Analytical Chemistry

Maximal Oxidative Capacity during Exercise Is Associated with Skeletal Muscle Fuel Selection and Dynamic Changes in Mitochondrial Protein Acetylation

(2015) Katherine A. Overmyer et al.   Cell Metabolism

How to measure metabolic fluxes: a taxonomic guide for 13 C fluxomics

(2015) Sebastian Niedenführ et al.   CURRENT OPINION IN BIOTECHNOLOGY

Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide-derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling

(2015) Matthew S. Brook et al.   FASEB JOURNAL

Radio frequency quadrupole technology: Evolution and contributions to mass spectrometry

(2015) Raymond E. March et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Paleodietary reconstruction using stable isotopes and abundance analysis of bovids from the Shungura Formation of South Omo, Ethiopia

(2015) Enquye W. Negash et al.   JOURNAL OF HUMAN EVOLUTION

Turnover Rates of Hepatic Collagen and Circulating Collagen-Associated Proteins in Humans with Chronic Liver Disease

(2015) Martin L. Decaris et al.   PLoS One

Analytical methods and application of stable isotopes in dissolved organic carbon and inorganic carbon in groundwater

(2015) Yinzhu Zhou et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Colloquium: 100 years of mass spectrometry: Perspectives and future trends

(2015) Simon Maher et al.   REVIEWS OF MODERN PHYSICS

A validation of the application of D2O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans

(2014) Daniel J. Wilkinson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Total body skeletal muscle mass: estimation by creatine (methyl-d3) dilution in humans

(2014) Richard V. Clark et al.   JOURNAL OF APPLIED PHYSIOLOGY

Quantitative amino acid profiling and stable isotopically labeled amino acid tracer enrichment used for in vivo human systemic and tissue kinetics measurements

(2014) Andreas Bornø et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Determination of human muscle protein fractional synthesis rate: an evaluation of different mass spectrometry techniques and considerations for tracer choice

(2014) Andreas Bornø et al.   JOURNAL OF MASS SPECTROMETRY

Glucose and glycerol concentrations and their tracer enrichment measurements using liquid chromatography tandem mass spectrometry

(2014) Andreas Bornø et al.   JOURNAL OF MASS SPECTROMETRY

Comparison of bolus injection and constant infusion methods for measuring muscle protein fractional synthesis rate in humans

(2014) Demidmaa Tuvdendorj et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Molecular phenotyping of a UK population: defining the human serum metabolome

(2014) Warwick B. Dunn et al.   Metabolomics

Proteomic Analysis of Altered Extracellular Matrix Turnover in Bleomycin-induced Pulmonary Fibrosis

(2014) Martin L. Decaris et al.   MOLECULAR & CELLULAR PROTEOMICS

Acute Post-Exercise Myofibrillar Protein Synthesis Is Not Correlated with Resistance Training-Induced Muscle Hypertrophy in Young Men

(2014) Cameron J. Mitchell et al.   PLoS One

Application of stable isotopes to investigate the metabolism of fatty acids, glycerophospholipid and sphingolipid species

(2014) Josef Ecker et al.   PROGRESS IN LIPID RESEARCH

Current advances and strategies towards fully automated sample preparation for regulated LC–MS/MS bioanalysis

(2014) Naiyu Zheng et al.   Bioanalysis

Dynamic carbon 13 breath tests for the study of liver function and gastric emptying

(2014) L. Bonfrate et al.   Gastroenterology Report

Determination of steady-state protein breakdown rate in vivo by the disappearance of protein-bound tracer-labeled amino acids: a method applicable in humans

(2013) Lars Holm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization

(2013) Sayanti Bhattacharya et al.   ATHEROSCLEROSIS

Combining stable isotope (δ13C) of trace gases and aerobiological data to monitor the entry and dispersion of microorganisms in caves

(2013) E. Garcia-Anton et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

In vivo effects of anacetrapib on preβ HDL: improvement in HDL remodeling without effects on cholesterol absorption

(2013) Sheng-Ping Wang et al.   JOURNAL OF LIPID RESEARCH

Comparison of different mass spectrometry techniques in the measurement of L-[ring-13C6]phenylalanine incorporation into mixed muscle proteins

(2013) Piotr Zabielski et al.   JOURNAL OF MASS SPECTROMETRY

Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism

(2013) D. J. Wilkinson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oxygen isotope analyses of biogenic opal and quartz using a novel microfluorination technique

(2013) Anthony J. Menicucci et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

A novel oral tracer procedure for measurement of habitual myofibrillar protein synthesis

(2013) A. J. MacDonald et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Tracking fatty acid kinetics in distinct lipoprotein fractions in vivo: a novel high-throughput approach for studying dyslipidemia in rodent models

(2012) David G. McLaren et al.   JOURNAL OF LIPID RESEARCH

Muscle protein synthesis in response to nutrition and exercise

(2012) P. J. Atherton et al.   JOURNAL OF PHYSIOLOGY-LONDON

Calorie Restriction Does Not Increase Short-term or Long-term Protein Synthesis

(2012) B. F. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Plasma Proteome Dynamics: Analysis of Lipoproteins and Acute Phase Response Proteins with2H2O Metabolic Labeling

(2012) Ling Li et al.   MOLECULAR & CELLULAR PROTEOMICS

Sarcopenia, Dynapenia, and the Impact of Advancing Age on Human Skeletal Muscle Size and Strength; a Quantitative Review

(2012) W. Kyle Mitchell et al.   Frontiers in Physiology

John Waterlow, CMG, FRS, FRCP, DSc: an appreciation of his work as a physiologist

(2011) D Joe Millward et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Equilibration of 2H labeling between body water and free amino acids: Enabling studies of proteome synthesis

(2011) Kithsiri Herath et al.   ANALYTICAL BIOCHEMISTRY

Measuring protein synthesis using metabolic 2H labeling, high-resolution mass spectrometry, and an algorithm

(2011) Takhar Kasumov et al.   ANALYTICAL BIOCHEMISTRY

Measurement of human plasma proteome dynamics with 2H2O and liquid chromatography tandem mass spectrometry

(2011) John C. Price et al.   ANALYTICAL BIOCHEMISTRY

Applications of stable isotopes in clinical pharmacology

(2011) Reinout C. A. Schellekens et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Long-term synthesis rates of skeletal muscle DNA and protein are higher during aerobic training in older humans than in sedentary young subjects but are not altered by protein supplementation

(2011) Matthew M. Robinson et al.   FASEB JOURNAL

Appearance of D2O in Sweat after Oral and Oral-Intravenous Rehydration in Men

(2011) Holly Emmanuel et al.   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

Resting energy expenditure and protein turnover are increased in patients with severe chronic obstructive pulmonary disease

(2011) Christina C. Kao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Acute resistance exercise augments integrative myofibrillar protein synthesis

(2011) Heath G. Gasier et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Stable Isotope-Resolved Metabolomics (SIRM) in Cancer Research with Clinical Application to NonSmall Cell Lung Cancer

(2011) Andrew N. Lane et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Stable isotope-resolved metabolomics and applications for drug development

(2011) Teresa W.-M. Fan et al.   PHARMACOLOGY & THERAPEUTICS

An inter-laboratory comparative study into sample preparation for both reproducible and repeatable forensic 2H isotope analysis of human hair by continuous flow isotope ratio mass spectrometry

(2011) Wolfram Meier-Augenstein et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Cumulative responses of muscle protein synthesis are augmented with chronic resistance exercise training

(2010) H. G. Gasier et al.   Acta Physiologica

Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling

(2010) Philip J Atherton et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Measurement of protein synthesis using heavy water labeling and peptide mass spectrometry: Discrimination between major histocompatibility complex allotypes

(2010) Alessandra De Riva et al.   ANALYTICAL BIOCHEMISTRY

Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

(2010) Warwick B. Dunn et al.   CHEMICAL SOCIETY REVIEWS

An overview of matrix effects in liquid chromatography-mass spectrometry

(2010) Helga Trufelli et al.   MASS SPECTROMETRY REVIEWS

The application of 2H2O to measure skeletal muscle protein synthesis

(2010) Heath G Gasier et al.   Nutrition & Metabolism

Analysis of proteome dynamics in the mouse brain

(2010) J. C. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An update of MALDI-TOF mass spectrometry in lipid research

(2010) Beate Fuchs et al.   PROGRESS IN LIPID RESEARCH

Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia

(2009) Emilie A Wilkes et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Recent progress in stable isotope methods for assessing vitamin metabolism

(2009) Leslie JC Bluck   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Measuring Proteome Dynamicsin Vivo

(2009) Nadia Rachdaoui et al.   MOLECULAR & CELLULAR PROTEOMICS

Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

(2009) Teresa WM Fan et al.   Molecular Cancer

Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma

(2009) Terri A Addona et al.   NATURE BIOTECHNOLOGY

Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle

(2008) P. L. Greenhaff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Brief History of Mass Spectrometry

(2008) Jennifer Griffiths   ANALYTICAL CHEMISTRY

An overview of proteomic and metabolomic technologies and their application to pregnancy research

(2008) RP Horgan et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Determination of protein synthesis in vivo using labeling from deuterated water and analysis of MALDI-TOF spectrum

(2008) Gary Guishan Xiao et al.   JOURNAL OF APPLIED PHYSIOLOGY

Application of liquid chromatography-tandem mass spectrometry (LC–MS/MS) for the analysis of stable isotope enrichments of phenylalanine and tyrosine

(2008) Roland J.W. Meesters et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Liquid and gas chromatography coupled to isotope ratio mass spectrometry for the determination of13C-valine isotopic ratios in complex biological samples

(2008) Jean-Philippe Godin et al.   JOURNAL OF MASS SPECTROMETRY

Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men

(2008) Vinod Kumar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Quantitative proteomics as a new piece of the systems biology puzzle

(2008) Angela Bachi et al.   Journal of Proteomics