Drug formulation and nanomedicine approaches to targeting lymphatic cancer metastases

Efficacy of a novel LyP-1-containing self-microemulsifying drug delivery system (SMEDDS) for active targeting to breast cancer

(2019) Selin S. Timur et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Lymph node metastases: importance of detection and treatment strategies

(2018) Antonella Obinu et al.   Expert Opinion on Drug Delivery

Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review

(2018) Nadda Muhamad et al.   International Journal of Nanomedicine

Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system

(2018) Jong Bong Lee et al.   JOURNAL OF CONTROLLED RELEASE

Cell-penetrating peptide-based nanovehicles potentiate lymph metastasis targeting and deep penetration for anti-metastasis therapy

(2018) Haiyan Hu et al.   Theranostics

Soft- and hard-lipid nanoparticles: a novel approach to lymphatic drug delivery

(2018) Seung-Hyun Jeong et al.   ARCHIVES OF PHARMACAL RESEARCH

Lymph cancer chemotherapy: delivery of doxorubicin-gemcitabine prodrug and vincristine by nanostructured lipid carriers

(2017) Shuqin Ni et al.   International Journal of Nanomedicine

Review of toxicity studies of carbon nanotubes

(2017) Norihiro Kobayashi et al.   JOURNAL OF OCCUPATIONAL HEALTH

Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site

(2017) Gemma M. Ryan et al.   Nanomedicine-Nanotechnology Biology and Medicine

Glyceride-Mimetic Prodrugs Incorporating Self-Immolative Spacers Promote Lymphatic Transport, Avoid First-Pass Metabolism, and Enhance Oral Bioavailability

(2016) Luojuan Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Potential of erlotinib cyclodextrin nanosponge complex to enhance solubility, dissolution rate, in vitro cytotoxicity and oral bioavailability

(2016) Chander Parkash Dora et al.   CARBOHYDRATE POLYMERS

Conjugation of 10 kDa Linear PEG onto Trastuzumab Fab′ Is Sufficient to Significantly Enhance Lymphatic Exposure while Preserving in Vitro Biological Activity

(2016) Linda J. Chan et al.   MOLECULAR PHARMACEUTICS

Lymphatic Transport and Lymphocyte Targeting of a Triglyceride Mimetic Prodrug Is Enhanced in a Large Animal Model: Studies in Greyhound Dogs

(2016) Sifei Han et al.   MOLECULAR PHARMACEUTICS

The relationship of lymphatic vessel density, lymphovascular invasion, and lymph node metastasis in breast cancer: a systematic review and meta-analysis

(2016) Song Zhang et al.   Oncotarget

Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers

(2015) Horacio Cabral et al.   ACS Nano

The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis

(2015) Kyung Ho Pak et al.   BMC CANCER

A three-drug nanoscale drug delivery system designed for preferential lymphatic uptake for the treatment of metastatic melanoma

(2015) Bhuvana S. Doddapaneni et al.   JOURNAL OF CONTROLLED RELEASE

Methotrexate-Conjugated PEGylated Dendrimers Show Differential Patterns of Deposition and Activity in Tumor-Burdened Lymph Nodes after Intravenous and Subcutaneous Administration in Rats

(2015) Lisa M. Kaminskas et al.   MOLECULAR PHARMACEUTICS

From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity

(2015) Natalie L. Trevaskis et al.   NATURE REVIEWS DRUG DISCOVERY

Nab-paclitaxel Efficacy in the Orthotopic Model of Human Breast Cancer Is Significantly Enhanced By Concurrent Anti–Vascular Endothelial Growth Factor A Therapy

(2015) Lisa D. Volk et al.   NEOPLASIA

Cancer active targeting by nanoparticles: a comprehensive review of literature

(2014) Remon Bazak et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Targeted delivery of a model immunomodulator to the lymphatic system: Comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies

(2014) Sifei Han et al.   JOURNAL OF CONTROLLED RELEASE

Preparation of vincristine sulfate-loaded poly (butylcyanoacrylate) nanoparticles modified with pluronic F127 and evaluation of their lymphatic tissue targeting

(2014) Rong Tan et al.   JOURNAL OF DRUG TARGETING

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

Protein Nanoparticles as Drug Delivery Carriers for Cancer Therapy

(2014) Warangkana Lohcharoenkal et al.   Biomed Research International

PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin

(2013) Gemma M. Ryan et al.   JOURNAL OF CONTROLLED RELEASE

Polymeric micelles for enhanced lymphatic drug delivery to treat metastatic tumors

(2013) Lei Qin et al.   JOURNAL OF CONTROLLED RELEASE

PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases

(2013) Lisa M. Kaminskas et al.   JOURNAL OF CONTROLLED RELEASE

Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety

(2013) L. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevention of nodal metastases in breast cancer following the lymphatic migration of paclitaxel-loaded expansile nanoparticles

(2012) Rong Liu et al.   BIOMATERIALS

Drug Absorption Interactions Between Oral Targeted Anticancer Agents and PPIs: Is pH-Dependent Solubility the Achilles Heel of Targeted Therapy?

(2012) N R Budha et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Nanoparticle Migration and Delivery of Paclitaxel to Regional Lymph Nodes in a Large Animal Model

(2012) Onkar V. Khullar et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

LyP-1 Modification To Enhance Delivery of Artemisinin or Fluorescent Probe Loaded Polymeric Micelles to Highly Metastatic Tumor and Its Lymphatics

(2012) Zhaohui Wang et al.   MOLECULAR PHARMACEUTICS

Association of Chemotherapeutic Drugs with Dendrimer Nanocarriers: An Assessment of the Merits of Covalent Conjugation Compared to Noncovalent Encapsulation

(2012) Lisa M. Kaminskas et al.   MOLECULAR PHARMACEUTICS

Targeting the lymphatics using dendritic polymers (dendrimers)

(2011) Lisa M. Kaminskas et al.   ADVANCED DRUG DELIVERY REVIEWS

Dendrimer Display of Tumor-Homing Peptides

(2011) Edith H. M. Lempens et al.   BIOCONJUGATE CHEMISTRY

LyP-1-conjugated PEGylated liposomes: A carrier system for targeted therapy of lymphatic metastatic tumor

(2011) Zhiqiang Yan et al.   JOURNAL OF CONTROLLED RELEASE

Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties

(2011) Lisa M Kaminskas et al.   Nanomedicine

A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems

(2011) Lisa M. Kaminskas et al.   Nanomedicine-Nanotechnology Biology and Medicine

LyP-1-conjugated doxorubicin-loaded liposomes suppress lymphatic metastasis by inhibiting lymph node metastases and destroying tumor lymphatics

(2011) Zhiqiang Yan et al.   NANOTECHNOLOGY

LAH4 enhances CD8+ T cell immunity of protein/peptide-based vaccines

(2011) Tong Tong Zhang et al.   VACCINE

Significance of lymphangiogenesis in primary tumor and draining lymph nodes during lymphatic metastasis of pancreatic head cancer

(2010) Hiroshi Kurahara et al.   JOURNAL OF SURGICAL ONCOLOGY

Morbidity results from the NSABP B-32 trial comparing sentinel lymph node dissection versus axillary dissection

(2010) Takamaru Ashikaga et al.   JOURNAL OF SURGICAL ONCOLOGY

Hydrophilic multi-walled carbon nanotubes decorated with magnetite nanoparticles as lymphatic targeted drug delivery vehicles

(2009) Dong Yang et al.   CHEMICAL COMMUNICATIONS

Emerging PEGylated drugs

(2009) Jung Seok Kang et al.   EXPERT OPINION ON EMERGING DRUGS

Engineered chylomicron mimicking carrier emulsome for lymph targeted oral delivery of methotrexate

(2009) Rishi Paliwal et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats

(2009) Lisa M. Kaminskas et al.   JOURNAL OF CONTROLLED RELEASE

Biodegradable PLGA based nanoparticles for sustained regional lymphatic drug delivery

(2009) Deepa A. Rao et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Macrophage mannose receptor on lymphatics controls cell trafficking

(2008) F. Marttila-Ichihara et al.   BLOOD

Application of Nanotechnology in Cancer Therapy and Imaging

(2008) X. Wang et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Mitochondrial/Cell-Surface Protein p32/gC1qR as a Molecular Target in Tumor Cells and Tumor Stroma

(2008) V. Fogal et al.   CANCER RESEARCH

Lymphatic targeting of zidovudine using surface-engineered liposomes

(2008) Chanchal Deep Kaur et al.   JOURNAL OF DRUG TARGETING

The Impact of Molecular Weight and PEG Chain Length on the Systemic Pharmacokinetics of PEGylated Polyl-Lysine Dendrimers

(2008) Lisa M. Kaminskas et al.   MOLECULAR PHARMACEUTICS

Effect of lipid core material on characteristics of solid lipid nanoparticles designed for oral lymphatic delivery

(2008) Rishi Paliwal et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis

(2008) E. A. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane permeable peptide vectors: chemistry and functional design for the therapeutic applications

(2007) Shiroh Futaki   ADVANCED DRUG DELIVERY REVIEWS

Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin

(2007) Fu-Qiang Hu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS