Dihydroartemisinin Regulates the Th/Treg Balance by Inducing Activated CD4+ T cell Apoptosis via Heme Oxygenase-1 Induction in Mouse Models of Inflammatory Bowel Disease

Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis via suppressing neutrophils and macrophages

(2018) Yu-xi Yan et al.   ACTA PHARMACOLOGICA SINICA

BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis

(2018) Jinfeng Zhou et al.   Cellular & Molecular Immunology

The effects of dihydroartemisinin on inflammatory bowel disease-related bone loss in a rat model

(2018) Xingtao Ge et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Pathogenic role for macrophage migration inhibitory factor in glioblastoma and its targeting with specific inhibitors as novel tailored therapeutic approach

(2018) Katia Mangano et al.   Oncotarget

TRAIL-Mediated Suppression of T Cell Receptor Signaling Inhibits T Cell Activation and Inflammation in Experimental Autoimmune Encephalomyelitis

(2018) I-Tsu Chyuan et al.   Frontiers in Immunology

Histopathologic Features of Inflammatory Bowel Disease are Associated with Different CD4+ T Cell Subsets in Colonic Mucosal Lamina Propria

(2018) Xianyong Gui et al.   Journal of Crohns & Colitis

The sinister face of heme oxygenase-1 in brain aging and disease

(2018) Hyman M. Schipper et al.   PROGRESS IN NEUROBIOLOGY

Heme Oxygenase-1 as a Modulator of Intestinal Inflammation Development and Progression

(2018) Valentina P. Sebastián et al.   Frontiers in Immunology

Role of MIF and D-DT in immune-inflammatory, autoimmune, and chronic respiratory diseases: from pathogenic factors to therapeutic targets

(2018) Sven Günther et al.   DRUG DISCOVERY TODAY

DC32, a Dihydroartemisinin Derivative, Ameliorates Collagen-Induced Arthritis Through an Nrf2-p62-Keap1 Feedback Loop

(2018) Menglin Fan et al.   Frontiers in Immunology

Circulating and Tissue-Resident CD4 + T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation

(2017) Ahmed N. Hegazy et al.   GASTROENTEROLOGY

Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases

(2017) Florian Rieder et al.   GASTROENTEROLOGY

Increased risk of acute arterial events in young patients and severely active IBD: a nationwide French cohort study

(2017) Julien Kirchgesner et al.   GUT

Role of macrophage migration inhibitory factor in head and neck cancer and novel therapeutic targets: A systematic review

(2017) Jérôme R. Lechien et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Integrated Analysis of Biopsies from Inflammatory Bowel Disease Patients Identifies SAA1 as a Link Between Mucosal Microbes with TH17 and TH22 Cells

(2017) Mei San Tang et al.   INFLAMMATORY BOWEL DISEASES

Patient Understanding of the Risks and Benefits of Biologic Therapies in Inflammatory Bowel Disease

(2017) Bibiana Martinez et al.   INFLAMMATORY BOWEL DISEASES

Inhibition of effector antigen-specific T cells by intradermal administration of heme oxygenase-1 inducers

(2017) Thomas Simon et al.   JOURNAL OF AUTOIMMUNITY

Involvement of the Nrf2/HO-1/CO axis and therapeutic intervention with the CO-releasing molecule CORM-A1, in a murine model of autoimmune hepatitis

(2017) Katia Mangano et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chemically induced mouse models of acute and chronic intestinal inflammation

(2017) Stefan Wirtz et al.   Nature Protocols

Clonal evolution of colorectal cancer in IBD

(2017) Chang-Ho R. Choi et al.   Nature Reviews Gastroenterology & Hepatology

JNK Pathway-Associated Phosphatase/DUSP22 Suppresses CD4+ T-Cell Activation and Th1/Th17-Cell Differentiation and Negatively Correlates with Clinical Activity in Inflammatory Bowel Disease

(2017) Rui Zhou et al.   Frontiers in Immunology

Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture)

(2016) Youyou Tu   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Artesunate inhibits type I interferon-induced production of macrophage migration inhibitory factor in patients with systemic lupus erythematosus

(2016) X Feng et al.   LUPUS

Carbon monoxide-releasing molecule-A1 (CORM-A1) improves clinical signs of experimental autoimmune uveoretinitis (EAU) in rats

(2015) Paolo Fagone et al.   CLINICAL IMMUNOLOGY

Macrophage migration inhibitory factor involvement in breast cancer (Review)

(2015) VINCENT RICHARD et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

5-Aminolevulinic acid with ferrous iron induces permanent cardiac allograft acceptance in mice via induction of regulatory cells

(2015) Jiangang Hou et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

Epidemiology and risk factors for IBD

(2015) Ashwin N. Ananthakrishnan   Nature Reviews Gastroenterology & Hepatology

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

(2015) Jigang Wang et al.   Nature Communications

The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome

(2015) Sara Omenetti et al.   Frontiers in Immunology

Heme Enzyme Structure and Function

(2014) Thomas L. Poulos   CHEMICAL REVIEWS

Pharmacological application of carbon monoxide ameliorates islet-directed autoimmunity in mice via anti-inflammatory and anti-apoptotic effects

(2014) Ivana Nikolic et al.   DIABETOLOGIA

TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

(2014) Katharina Gerlach et al.   NATURE IMMUNOLOGY

Chronic Macrophage Migration Inhibitory Factor Exposure Induces Mesenchymal Epithelial Transition and Promotes Gastric and Colon Cancers

(2014) Katherine T. Morris et al.   PLoS One

Single cell behavior in T cell differentiation

(2014) Jan C. Rohr et al.   TRENDS IN IMMUNOLOGY

Immunomodulatory and Anti-inflammatory Properties of Artesunate in Experimental Colitis

(2012) Z. Yang et al.   CURRENT MEDICINAL CHEMISTRY

Dihydroartemisinin Ameliorates Inflammatory Disease by Its Reciprocal Effects on Th and Regulatory T Cell Function via Modulating the Mammalian Target of Rapamycin Pathway

(2012) Yan G. Zhao et al.   JOURNAL OF IMMUNOLOGY

Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1

(2011) P. Fagone et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Guidelines for the management of inflammatory bowel disease in adults

(2011) C. Mowat et al.   GUT

Lymph node-derived donor encephalitogenic CD4+ T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet

(2011) Petra D Cravens et al.   Journal of Neuroinflammation

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

(2011) Youyou Tu   NATURE MEDICINE

Heme as Trigger and Target for Trioxane-Containing Antimalarial Drugs†

(2010) Bernard Meunier et al.   ACCOUNTS OF CHEMICAL RESEARCH

SM934, a water-soluble derivative of arteminisin, exerts immunosuppressive functions in vitro and in vivo

(2009) Li-Fei Hou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY