Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.01956
Keywords
heme oxygenase-1; inflammatory bowel disease; carbon monoxide; infection; inflammation; nuclear factor erythroid 2-related factor 2; colorectal cancer; microbiota
Categories
Funding
- Fondo Nacional de Desarrollo Cientifico y Tecnologico FONDECYT [1131012, 1161525, 1170964]
- Millennium Institute on Immunology and Immunotherapy [P09/016-F]
- Iniciativa Cientifica Milenio from the Ministry of Economy and Tourism
- Direccion de Investigacion, Vicerrectoria de Investigacion from the Pontificia Universidad Catolica de Chile [P1715/2017]
- National Council of Scientific and Technological Research (CONICYT) [21140273, 21140169, 21171014, 63140215]
- Vicerrectoria de Investigacion from the Pontificia Universidad Catolica de Chile
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Heme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the heme group contained in several important proteins, such as hemoglobin, myoglobin, and cytochrome p450. The enzymatic reaction catalyzed by HMOX1 generates Fe2+, biliverdin and CO. It has been shown that HMOX1 activity and the by-product CO can downmodulate the damaging immune response in several models of intestinal inflammation as a result of pharmacological induction of HMOX1 expression and the administration of non-toxic amounts of CO. Inflammatory Bowel Diseases, which includes Crohn's Disease (CD) and Ulcerative Colitis (UC), are one of the most studied ailments associated to HMOX1 effects. However, microbiota imbalances and infections are also important factors influencing the occurrence of acute and chronic intestinal inflammation, where HMOX1 activity may play a major role. As part of this article we discuss the immune modulatory capacity of HMOX1 during IBD, as well during the infections and interactions with the microbiota that contribute to this inflammatory disease.
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