Heterologous Expression of Ilicicolin H Biosynthetic Gene Cluster and Production of a New Potent Antifungal Reagent, Ilicicolin J

Genome-Mined Diels–Alderase Catalyzes Formation of the cis-Octahydrodecalins of Varicidin A and B

(2019) Dan Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme-Catalyzed Inverse-Electron Demand Diels–Alder Reaction in the Biosynthesis of Antifungal Ilicicolin H

(2019) Zhuan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia

(2018) Alexander Rosenberg et al.   Nature Communications

A Dereplication and Bioguided Discovery Approach to Reveal New Compounds from a Marine-Derived Fungus Stilbella fimetaria

(2017) Sara Kildgaard et al.   Marine Drugs

SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis

(2017) Masao Ohashi et al.   NATURE

A scalable platform to identify fungal secondary metabolites and their gene clusters

(2017) Kenneth D Clevenger et al.   Nature Chemical Biology

Natural products from filamentous fungi and production by heterologous expression

(2016) Fabrizio Alberti et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biochemical Characterization of a Eukaryotic Decalin-Forming Diels–Alderase

(2016) Li Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis

(2015) Naoki Kato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An Aspergillus flavus secondary metabolic gene cluster containing a hybrid PKS–NRPS is necessary for synthesis of the 2-pyridones, leporins

(2015) Jeffrey W. Cary et al.   FUNGAL GENETICS AND BIOLOGY

The structure of SpnF, a standalone enzyme that catalyzes [4 + 2] cycloaddition

(2015) Christopher D Fage et al.   Nature Chemical Biology

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

(2015) Tilmann Weber et al.   NUCLEIC ACIDS RESEARCH

Structure–activity relationship of cytochrome bc1 reductase inhibitor broad spectrum antifungal ilicicolin H

(2013) Sheo B. Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans

(2013) Junko Yaegashi et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Antifungal Spectrum, In Vivo Efficacy, and Structure–Activity Relationship of Ilicicolin H

(2012) Sheo B. Singh et al.   ACS Medicinal Chemistry Letters

Nongenetic Reprogramming of a Fungal Highly Reducing Polyketide Synthase

(2011) Ahmed A. Yakasai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct Metabolite

(2011) Katja M. Fisch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A

(2011) Hak Joong Kim et al.   NATURE

Biotransformation of antifungal ilicicolin H

(2011) Sheo B. Singh et al.   TETRAHEDRON LETTERS

Analysis of Intact and Dissected Fungal Polyketide Synthase-Nonribosomal Peptide Synthetase in Vitro and inSaccharomyces cerevisiae

(2010) Wei Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase

(2009) S. M. Ma et al.   SCIENCE

Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase

(2008) Laura M. Halo et al.   CHEMBIOCHEM

Late Stage Oxidations during the Biosynthesis of the 2-Pyridone Tenellin in the Entomopathogenic FungusBeauveria bassiana

(2008) Laura M. Halo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY