Pharmacological, Mechanistic, and Pharmacokinetic Assessment of Novel Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs

Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life: Implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin-mediated osteoblastogenesis

(2018) Sifat Maria et al.   JOURNAL OF PINEAL RESEARCH

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

(2017) Yalikun Suofu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of resistance to endocrine therapy in breast cancer: the important role of PI3K/Akt/mTOR in estrogen receptor-positive, HER2-negative breast cancer

(2017) Kazuhiro Araki et al.   Breast Cancer

A Novel Strategy to Co-target Estrogen Receptor and Nuclear Factor κB Pathways with Hybrid Drugs for Breast Cancer Therapy

(2017) Irida Kastrati et al.   Hormones & Cancer

Sustained release of melatonin: A novel approach in elevating efficacy of tamoxifen in breast cancer treatment

(2016) Mehdi Sabzichi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The MEK5/ERK5 signalling pathway in cancer: a promising novel therapeutic target

(2016) André E.S. Simões et al.   DRUG DISCOVERY TODAY

Melatonin: an inhibitor of breast cancer

(2015) S. M. Hill et al.   ENDOCRINE-RELATED CANCER

Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers

(2015) Sally Temraz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quantitative monitoring of tamoxifen in human plasma extended to 40 metabolites using liquid-chromatography high-resolution mass spectrometry: new investigation capabilities for clinical pharmacology

(2014) Elyes Dahmane et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Pharmacokinetics of endoxifen and tamoxifen in female mice: implications for comparative in vivo activity studies

(2014) Joel M. Reid et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer

(2014) R. T. Dauchy et al.   CANCER RESEARCH

High affinity nuclear and nongenomic estradiol binding sites in the human and mouse lens

(2013) M. Rachel Kirker et al.   EXPERIMENTAL EYE RESEARCH

Histone Deacetylase Inhibitors Equipped with Estrogen Receptor Modulation Activity

(2013) Berkley E. Gryder et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tamoxifen Resistance in Breast Cancer

(2012) Min-Sun Chang   Biomolecules & Therapeutics

Clinical and biomarker predictors of side effects from tamoxifen

(2011) Wendy Lorizio et al.   BREAST CANCER RESEARCH AND TREATMENT

Activation of the ERK1/2 Mitogen-Activated Protein Kinase Cascade by Dentin Matrix Protein 1 Promotes Osteoblast Differentiation

(2011) Asha Eapen et al.   CELLS TISSUES ORGANS

Melatonin osteoporosis prevention study (MOPS): a randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women

(2011) Mary P. Kotlarczyk et al.   JOURNAL OF PINEAL RESEARCH

Long-Term Outcomes of Invasive Ipsilateral Breast Tumor Recurrences After Lumpectomy in NSABP B-17 and B-24 Randomized Clinical Trials for DCIS

(2011) I. L. Wapnir et al.   JNCI-Journal of the National Cancer Institute

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

(2010) Yohannes Mebratu et al.   CELL CYCLE

Determination of the minimal melatonin exposure required to induce osteoblast differentiation from human mesenchymal stem cells and these effects on downstream signaling pathways

(2010) Shalini Sethi et al.   JOURNAL OF PINEAL RESEARCH

Stimulating the GPR30 Estrogen Receptor with a Novel Tamoxifen Analogue Activates SF-1 and Promotes Endometrial Cell Proliferation

(2009) Benjamin C. Lin et al.   CANCER RESEARCH

Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives

(2009) Stephen G. Grant et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Molecular Mechanisms of Melatonin Anticancer Effects

(2009) Steven M. Hill et al.   INTEGRATIVE CANCER THERAPIES