Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

Differential expression of the immediate early genes c-Fos , Arc , Egr-1 , and Npas4 during long-term memory formation in the context preexposure facilitation effect (CPFE)

(2018) Nicholas A. Heroux et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Picomolar Amyloid-β Peptides Enhance Spontaneous Astrocyte Calcium Transients

(2018) Linda Lee et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduced gliotransmitter release from astrocytes mediates tau-induced synaptic dysfunction in cultured hippocampal neurons

(2017) Roberto Piacentini et al.   GLIA

Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer’s Disease

(2017) Jole Fiorito et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Involvement of NR2B and tau Protein in MG132-Induced CREB Dephosphorylation

(2017) Min Xie et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

(2017) Daniela Puzzo et al.   eLife

Evidence that Non-Fibrillar Tau Causes Pathology Linked to Neurodegeneration and Behavioral Impairments

(2017) Kurt R. Brunden et al.   JOURNAL OF ALZHEIMERS DISEASE

Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease

(2017) Yitshak I. Francis et al.   JOURNAL OF ALZHEIMERS DISEASE

Nitric Oxide Homeostasis in Neurodegenerative Diseases

(2016) Luciana Hannibal   Current Alzheimer Research

Reduced pCREB in Alzheimer’s disease prefrontal cortex is reflected in peripheral blood mononuclear cells

(2016) N Bartolotti et al.   MOLECULAR PSYCHIATRY

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

(2016) M. Fá et al.   Scientific Reports

Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau

(2015) Muneaki Takahashi et al.   ACTA NEUROPATHOLOGICA

Nitric Oxide Signaling Is Recruited As a Compensatory Mechanism for Sustaining Synaptic Plasticity in Alzheimer's Disease Mice

(2015) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach

(2015) Andrew F. Teich et al.   Neurotherapeutics

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

S-Nitrosylation in Alzheimer's disease

(2014) Qing-Fei Zhao et al.   MOLECULAR NEUROBIOLOGY

APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

(2014) Hilla Fogel et al.   Cell Reports

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation

(2013) Alex Crowe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-Tau Antibodies: Hitting the Target

(2013) Todd E. Golde et al.   NEURON

Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3β, Neurotrophin-3 and CREB Signaling

(2013) Yuan-Shih Hu et al.   PLoS One

Inhibition of phosphodiesterase-5 rescues age-related impairment of synaptic plasticity and memory

(2012) Agostino Palmeri et al.   BEHAVIOURAL BRAIN RESEARCH

Synthesis of quinoline derivatives: Discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease

(2012) Jole Fiorito et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's  -Secretase (BACE1) Regulates the cAMP/PKA/CREB Pathway Independently of  -Amyloid

(2012) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Early Presynaptic and Postsynaptic Calcium Signaling Abnormalities Mask Underlying Synaptic Depression in Presymptomatic Alzheimer's Disease Mice

(2012) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

(2012) Cristian A. Lasagna-Reeves et al.   Scientific Reports

The role of NR4A transcription factors in memory formation

(2011) Josh D. Hawk et al.   BRAIN RESEARCH BULLETIN

Are Tangles as Toxic as They Look?

(2011) Tara L. Spires-Jones et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

(2011) Subbiah Pugazhenthi et al.   Molecular Neurodegeneration

Cortical peroxynitration of nerve growth factor in aged and cognitively impaired rats

(2011) Martin A. Bruno et al.   NEUROBIOLOGY OF AGING

Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+signaling

(2011) Marioly Müller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preparation and Characterization of Neurotoxic Tau Oligomers

(2010) Cristian A. Lasagna-Reeves et al.   BIOCHEMISTRY

Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model

(2010) A. Boutajangout et al.   JOURNAL OF NEUROSCIENCE

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

(2010) S. H. Francis et al.   PHARMACOLOGICAL REVIEWS

CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease

(2010) A. Caccamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β-Peptide Directly Induces Spontaneous Calcium Transients, Delayed Intercellular Calcium Waves and Gliosis in Rat Cortical Astrocytes

(2009) Siu-Kei Chow et al.   ASN Neuro

Calcitonin gene-related peptide enhances CREB phosphorylation and attenuates tau protein phosphorylation in rat brain during focal cerebral ischemia/reperfusion

(2009) Zheng-Hong Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid-  Load in an Alzheimer's Disease Mouse Model

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

The molecular and cellular biology of enhanced cognition

(2009) Yong-Seok Lee et al.   NATURE REVIEWS NEUROSCIENCE

Phosphodiesterase Inhibitors Enhance Object Memory Independent of Cerebral Blood Flow and Glucose Utilization in Rats

(2009) Kris Rutten et al.   NEUROPSYCHOPHARMACOLOGY

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Detecting navigational deficits in cognitive aging and Alzheimer disease using virtual reality

(2008) L. A. Cushman et al.   NEUROLOGY