4.8 Editorial Material

Anti-Tau Antibodies: Hitting the Target

Journal

NEURON
Volume 80, Issue 2, Pages 254-256

Publisher

CELL PRESS
DOI: 10.1016/j.neuron.2013.10.009

Keywords

-

Categories

Ask authors/readers for more resources

Immunotherapies targeting tau in mouse models of human tauopathies could have disease-modifying effects. In this issue of Neuron, Yanamandra et al. (2013) use tau antibodies, which effectively block tau seeding in culture, to attenuate tauopathy and improve cognition in mutant tau mouse models.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Neurosciences

Statistically Defined Parkinson's Disease Executive and Memory Cognitive Phenotypes: Demographic, Behavioral, and Structural Neuroimaging Comparisons

Samuel J. Crowley, Guita Banan, Manish Amin, Jared J. Tanner, Loren Hizel, Peter Nguyen, Babette Brumback, Katie Rodriguez, Nikolaus McFarland, Dawn Bowers, Mingzhou Ding, Thomas A. Mareci, Catherine C. Price

Summary: This study aimed to statistically derive PD executive and memory phenotypes, comparing them on various disease and demographic variables, vascular risk factors, and specific neuroimaging variables related to executive and memory function. The clusters identified different structural gray and white matter patterns, with PD Executive showing less subcortical gray matter and white matter compared to PD Memory and PD Cognitively Well. These findings provide insights into phenotypic demographics, cognitive patterns, and structural brain profiles in individuals with PD.

JOURNAL OF PARKINSONS DISEASE (2021)

Article Neurosciences

The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism

Caroline M. Tanner, Steven R. Cummings, Michael A. Schwarzschild, Ethan G. Brown, E. Ray Dorsey, Alberto J. Espay, Nicholas B. Galifianakis, Samuel M. Goldman, Irene Litvan, Nijee Luthra, Nikolaus R. McFarland, Kyle T. Mitchell, David G. Standaert, Douglas C. Bauer, Susan L. Greenspan, James C. Beck, Kenneth W. Lyles

Summary: TOPAZ is a clinical trial testing the efficacy of zoledronic acid for fracture prevention in patients with Parkinson's disease, with a unique home-based design to enhance feasibility and convenience for participants.

NPJ PARKINSONS DISEASE (2021)

Article Neurosciences

Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy

Ethan W. Hass, Zachary A. Sorrentino, Grace M. Lloyd, Nikolaus R. McFarland, Stefan Prokop, Benoit I. Giasson

Summary: Multiple system atrophy (MSA) is a neurodegenerative disease characterized by the accumulation of glial cytoplasmic inclusions (GCIs). Research has shown that MSA patients have abundant neuronal alpha Syn pathology in specific regions of the brain, which differs from GCIs and may play a role in driving the pathogenesis of MSA.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

Review Clinical Neurology

Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Consensus Statement of the CurePSP Centers of Care

Brent Bluett, Alexander Y. Pantelyat, Irene Litvan, Farwa Ali, Diana Apetauerova, Danny Bega, Lisa Bloom, James Bower, Adam L. Boxer, Marian L. Dale, Rohit Dhall, Antoine Duquette, Hubert H. Fernandez, Jori E. Fleisher, Murray Grossman, Michael Howell, Diana R. Kerwin, Julie Leegwater-Kim, Christiane Lepage, Peter Alexander Ljubenkov, Martina Mancini, Nikolaus R. McFarland, Paolo Moretti, Erica Myrick, Pritika Patel, Laura S. Plummer, Federico Rodriguez-Porcel, Julio Rojas, Christos Sidiropoulos, Miriam Sklerov, Leonard L. Sokol, Paul J. Tuite, Lawren VandeVrede, Jennifer Wilhelm, Anne-Marie A. Wills, Tao Xie, Lawrence Golbe

Summary: PSP and CBS are tauopathies with relentless progression, starting in the mid-60s and leading to death in about 7 years. Clinical deficits are diverse and include rigidity, bradykinesia, gait freezing, dystonia, apraxia, and cognitive dysfunction. CurePSP Centers of Care network was established in 2017 in North America to improve patient access to expertise and collaboration in managing these disorders.

FRONTIERS IN NEUROLOGY (2021)

Article Clinical Neurology

Diffusion Magnetic Resonance Imaging Detects Progression in Parkinson's Disease: A Placebo-Controlled Trial of Rasagiline

David J. Arpin, Trina Mitchell, Derek B. Archer, Roxana G. Burciu, Winston T. Chu, Hanzhi Gao, Thomas Guttuso, Christopher W. Hess, Song Lai, Irene A. Malaty, Nikolaus R. McFarland, Ofer Pasternak, Catherine C. Price, Aparna Wagle Shukla, Samuel S. Wu, Michael S. Okun, David E. Vaillancourt

Summary: The study did not find evidence that 1mg/day of rasagiline has a disease-modifying effect in Parkinson's Disease over 1 year. The free-water accumulation in pSN increased significantly over 1 year, and baseline free-water levels were related to clinical motor progression.

MOVEMENT DISORDERS (2022)

Article Clinical Neurology

Development and Validation of Automated Magnetic Resonance Parkinsonism Index 2.0 to Distinguish Progressive Supranuclear Palsy-Parkinsonism From Parkinson's Disease

Andrea Quattrone, Maria G. Bianco, Angelo Antonini, David E. Vaillancourt, Klaus Seppi, Roberto Ceravolo, Antonio P. Strafella, Gioacchino Tedeschi, Alessandro Tessitore, Roberto Cilia, Maurizio Morelli, Salvatore Nigro, Basilio Vescio, Pier Paolo Arcuri, Rosa De Micco, Mario Cirillo, Luca Weis, Eleonora Fiorenzato, Roberta Biundo, Roxana G. Burciu, Florian Krismer, Nikolaus R. McFarland, Christoph Mueller, Elke R. Gizewski, Mirco Cosottini, Eleonora Del Prete, Sonia Mazzucchi, Aldo Quattrone

Summary: This study developed an automated Magnetic Resonance Parkinsonism Index 2.0 (MRPI 2.0) algorithm to differentiate progressive supranuclear palsy-parkinsonism (PSP-P) from Parkinson's disease (PD) and validated its diagnostic performance in two large independent cohorts. The automated MRPI 2.0 showed excellent performance in distinguishing PSP-P from PD and control subjects in both cohorts, suggesting its generalizability. The use of the automated MRPI 2.0 algorithm could standardize measures in patients with PSP-P across centers and have a positive impact on multicenter studies and clinical trials.

MOVEMENT DISORDERS (2022)

Letter Clinical Neurology

Recommendations for Virtual Administration of the PSP Rating Scale

Anne-Marie Wills, Lawrence I. Golbe, Anthony E. Lang, Tao Xie, Marian L. Dale, Alberto Espay, Maria Carmela Tartaglia, Susan H. Fox, Sotirios Andreas Parashos, Nikolaus R. McFarland, Ruth B. Schneider, Federico Rodriguez-Porcel, Steven A. Gunzler, Alexander Pantelyat

MOVEMENT DISORDERS (2022)

Article Neurosciences

WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson's Disease Monocytes

Rebecca L. Wallings, Laura P. Hughes, Hannah A. Staley, Zachary D. Simon, Nikolaus R. McFarland, Roy N. Alcalay, Alicia Garrido, Maria Jose Marti, Eduardo Tolosa Sarro, Nicolas Dzamko, Malu Gamez Tansey

Summary: Both LRRK2 and GCase are potential targets for Parkinson's disease treatment, and their involvement in lysosome-related pathways has been suggested. This study developed a standardized protocol called WHOPPA using flow cytometry assays to measure LRRK2 and GCase activities in immune cells. The results showed increased LRRK2 levels and activity, decreased GCase index, and increased cytokine release in PD patient samples. The study also demonstrated a positive correlation between LRRK2 levels and the expression of pRab10 and HLA-DR in classical monocytes. This protocol could be used as a reliable and reproducible biomarker assay in larger cohorts of PD patients.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

Correction Biochemistry & Molecular Biology

Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial (August, 10.1038/s41591-021-01455-x, 2021)

Tien Dam, Adam L. Boxer, Lawrence I. Golbe, Gunter U. Hoglinger, Huw R. Morris, Irene Litvan, Anthony E. Lang, Jean-Christophe Corvol, Ikuko Aiba, Michael Grundman, Lili Yang, Beth Tidemann-Miller, Joseph Kupferman, Kristine Harper, Kubra Kamisoglu, Michael J. Wald, Danielle L. Graham, Liz Gedney, John O'Gorman, Samantha Budd Haeberlein, Ikuko Aiba, Angelo Antonini, Diana Apetauerova, Jean-Philippe Azulay, Ernest Balaguer Martinez, Jee Bang, Paolo Barone, Matthew Barrett, Danny Bega, Daniela Berg, Koldo Berganzo Corrales, Yvette Bordelon, Adam L. Boxer, Moritz Brandt, Norbert Brueggemann, Giovanni Castelnovo, Roberto Ceravolo, Rosalind Chuang, Sun Ju Chung, Alistair Church, Jean-Christophe Corvol, Paola Cudia, Marian Dale, Luc Defebvre, Sophie Drapier, Erika D. Driver-Dunckley, Georg Ebersbach, Karla M. Eggert, Aaron Ellenbogen, Alexandre Eusebio, Andrew H. Evans, Natalia Fedorova, Elizabeth Finger, Alexandra Foubert-Samier, Boyd Ghosh, Lawrence Golbe, Francisco Grandas Perez, Murray Grossman, Deborah Hall, Kyoko Hamada, Kazuko Hasegawa, Guenter Hoeglinger, Lawrence Honig, David Houghton, Xuemei Huang, Stuart Isaacson, SeongBeom Koh, Jaime Kulisevsky Bojarski, Anthony E. Lang, Peter Nigel Leigh, Irene Litvan, Juan Jose Lopez Lozano, Jose Luis Lopez-Sendon Moreno, Albert Christian Ludolph, Ma Rosario Luquin Piudo, Irene Martinez Torres, Nikolaus McFarland, Wassilios Meissner, Tiago Mestre, Pablo Mir Rivera, Eric Molho, Britt Mollenhauer, Huw R. Morris, Miho Murata, Tomokazu Obi, Fabienne Ory Magne, Padraig O'Suilleabhain, Rajesh Pahwa, Alexander Pantelyat, Nicola Pavese, Dmitry Pokhabov, Johannes Prudlo, Federico Rodriguez-Porcel, James Rowe, Joseph Savitt, Alfons Schnitzler, Joerg B. Schulz, Klaus Seppi, Binit Shah, Holly Shill, David Shprecher, Maria Stamelou, Malcolm Steiger, Yuji Takahashi, Hiroshi Takigawa, Carmela Tartaglia, Lars Toenges, Daniel Truong, Winona Tse, Paul Tuite, Dieter Volc, Anne-Marie A. Wills, Dirk Woitalla, Tao Xie, Tatsuhiko Yuasa, Sarah Elizabeth Zauber, Theresa Zesiewicz

NATURE MEDICINE (2022)

Article Medicine, Research & Experimental

Study in Parkinson's disease of exercise phase 3 (SPARX3): study protocol for a randomized controlled trial

Charity G. Patterson, Elizabeth Joslin, Alexandra B. Gil, Wendy Spigle, Todd Nemet, Lana Chahine, Cory L. Christiansen, Ed Melanson, Wendy M. Kohrt, Martina Mancini, Deborah Josbeno, Katherine Balfany, Garett Griffith, Mac Kenzie Dunlap, Guillaume Lamotte, Erin Suttman, Danielle Larson, Chantale Branson, Kathleen E. McKee, Li Goelz, Cynthia Poon, Barbara Tilley, Un Jung Kang, Malu Gamez Tansey, Nijee Luthra, Caroline M. Tanner, Jacob M. Haus, Giamila Fantuzzi, Nikolaus R. McFarland, Paulina Gonzalez-Latapi, Tatiana Foroud, Robert Motl, Michael A. Schwarzschild, Tanya Simuni, Kenneth Marek, Anna Naito, Codrin Lungu, Daniel M. Corcos

Summary: This article introduces a research study on the effects of high-intensity endurance exercise on the progression of Parkinson's disease. The study aims to explore whether high-intensity endurance training can slow down the progression of the disease, thus improving the quality of life for patients.

TRIALS (2022)

Article Neurosciences

Distinct cortical and subcortical predictors of Purdue Pegboard decline in Parkinson's disease and atypical parkinsonism

Bradley J. Wilkes, Emily R. Tobin, David J. Arpin, Wei-en Wang, Michael S. Okun, Michael S. Jaffee, Nikolaus R. McFarland, Daniel M. Corcos, David E. Vaillancourt

Summary: Objective measures of disease progression using the Purdue Pegboard Test (PPT) were conducted in patients with Parkinson's disease (PD), atypical Parkinsonism, and healthy controls. The decline in PPT performance in PD patients correlated with motor symptom progression, while no such decline was seen in controls. Neuroimaging measures from the basal ganglia were significant predictors of PPT performance in PD, and cortical, basal ganglia, and cerebellar regions were predictors for atypical Parkinsonism. Accelerometry in PD patients showed diminished acceleration range and irregular patterns, which correlated with PPT scores.

NPJ PARKINSONS DISEASE (2023)

Meeting Abstract Clinical Neurology

Enhancing Pandemic-Sensitive Recruitment Strategies for a Remote, Randomized Placebo-Controlled Trial for Fracture Prevention in Patients with Neurodegenerative Parkinsonisms (P1-1.Virtual)

Nijee Luthra, Ethan Brown, Samuel Goldman, Rafael Zuzuarregui, Trisha Hue, Christopher Schambach, Ian Bledsoe, Michael Schwarzschild, E. Ray Dorsey, Alberto Espay, Irene Litvan, Nikolaus McFarland, Kyle Mitchell, David Standaert, James Beck, Helen Rowbotham, Cheryl Meng, Jacque Perkins, Primi Ranola, Raymundo Picos, Dana Kriesel, Kenneth Lyles, Steve Cummings, Caroline Tanner

NEUROLOGY (2022)

Article Neuroimaging

Advanced diffusion imaging to track progression in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy

Trina Mitchell, Bradley J. Wilkes, Derek B. Archer, Winston T. Chu, Stephen A. Coombes, Song Lai, Nikolaus R. McFarland, Michael S. Okun, Mieniecia L. Black, Ellen Herschel, Tanya Simuni, Cynthia Comella, Mitra Afshari, Tao Xie, Hong Li, Todd B. Parrish, Ajay S. Kurani, Daniel M. Corcos, David E. Vaillancourt

Summary: Advanced diffusion imaging techniques can detect longitudinal changes in atypical Parkinsonian syndromes. The study found that MSAp and PSP had more declines in descending sensorimotor tracts compared to PD. PSP also showed longitudinal impairments in multiple transcallosal tracts, while MSAp and PD did not. Additionally, there were longitudinal changes in gray matter regions that had previously shown impairments in MSAp and PSP.

NEUROIMAGE-CLINICAL (2022)

Meeting Abstract Hospitality, Leisure, Sport & Tourism

Longitudinal Decline in Purdue Pegboard Performance in Parkinson's Disease

Emily R. Tobin, Bradely J. Wilkes, David J. Arpin, Michael S. Okun, Michael S. Jaffee, Nikolaus R. McFarland, Daniel M. Corcos, David E. Vaillancourt

JOURNAL OF SPORT & EXERCISE PSYCHOLOGY (2022)

Article Clinical Neurology

A New MRI Measure to Early Differentiate Progressive Supranuclear Palsy From De Novo Parkinson's Disease in Clinical Practice: An International Study

Andrea Quattrone, Angelo Antonini, David E. Vaillancourt, Klaus Seppi, Roberto Ceravolo, Antonio P. Strafella, Maurizio Morelli, Salvatore Nigro, Basilio Vescio, Maria G. Bianco, Roberta Vasta, Pier Paolo Arcuri, Luca Weis, Eleonora Fiorenzato, Roberta Biundo, Roxana G. Burciu, Florian Krismer, Nikolaus R. McFarland, Christoph Mueller, Elke R. Gizewski, Mirco Cosottini, Eleonora Del Prete, Sonia Mazzucchi, Aldo Quattrone

Summary: The measurement of third ventricle width can distinguish Parkinson's disease (PD) from progressive supranuclear palsy (PSP).

MOVEMENT DISORDERS (2021)

No Data Available