Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data

Systematic analysis of genes and diseases using PheWAS-Associated networks

(2019) Ali Khosravi et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Aspirin suppresses PGE2and activates AMP kinase to inhibit melanoma cell motility, pigmentation and selective tumor growthin vivo

(2018) Douglas Grossman et al.   Cancer Prevention Research

Immunomodulatory and enhanced antitumor activity of a modified thymosin α1 in melanoma and lung cancer

(2018) Fanwen Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Examining the Incidence and Presentation of Melanoma in the Cardiothoracic Transplant Population

(2018) Charles J. Puza et al.   JAMA Dermatology

Discovery and Validation of Clinical Biomarkers of Cancer: A Review Combining Metabolomics and Proteomics

(2018) Anubhav Srivastava et al.   PROTEOMICS

Rheumatoid Arthritis Complicated with Anti-melanoma Differentiation-associated Gene 5 Antibody-positive Interstitial Pneumonia

(2018) Haruki Matsumoto et al.   INTERNAL MEDICINE

Targeting tumor cells based on Phosphodiesterase 3A expression

(2017) Madiha Nazir et al.   EXPERIMENTAL CELL RESEARCH

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

HMDB 4.0: the human metabolome database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition

(2017) Keisha N. Hardeman et al.   Scientific Reports

Lipids-based nanostructured lipid carriers (NLCs) for improved oral bioavailability of sirolimus

(2016) Qin Yu et al.   DRUG DELIVERY

Cationic lipid-conjugated hydrocortisone as selective antitumor agent

(2016) Bhowmira Rathore et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Drug interaction between dabrafenib and immunosuppressive drugs

(2016) Matthieu Levavasseur et al.   MELANOMA RESEARCH

Estradiol differently affects melanin synthesis of malignant and normal melanocytes: a relationship with clock and clock-controlled genes

(2016) Maristela Oliveira Poletini et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Unravelling the human genome–phenome relationship using phenome-wide association studies

(2016) William S. Bush et al.   NATURE REVIEWS GENETICS

The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

(2016) Jacqueline MacArthur et al.   NUCLEIC ACIDS RESEARCH

Improved anti-melanoma effect of a transdermal mitoxantrone ethosome gel

(2015) Xiang Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

A survey of current trends in computational drug repositioning

(2015) Jiao Li et al.   BRIEFINGS IN BIOINFORMATICS

Omeprazole, a Gastric Proton Pump Inhibitor, Inhibits Melanogenesis by Blocking ATP7A Trafficking

(2015) Mary S. Matsui et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Opportunities for drug repositioning from phenome-wide association studies

(2015) Majid Rastegar-Mojarad et al.   NATURE BIOTECHNOLOGY

ClinVar: public archive of interpretations of clinically relevant variants

(2015) Melissa J. Landrum et al.   NUCLEIC ACIDS RESEARCH

Landscape of gene fusions in epithelial cancers: seq and ye shall find

(2015) Chandan Kumar-Sinha et al.   Genome Medicine

Drug Repositioning for Diabetes Based on 'Omics' Data Mining

(2015) Ming Zhang et al.   PLoS One

Ipilimumab-associated Sweet syndrome in a patient with high-risk melanoma

(2014) Rachel L. Kyllo et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders

(2014) Joanna S. Amberger et al.   NUCLEIC ACIDS RESEARCH

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

Comparison of RNA-Seq and Microarray in Transcriptome Profiling of Activated T Cells

(2014) Shanrong Zhao et al.   PLoS One

Suppression of metastasis by mirtazapine via restoration of the Lin-7C/β-catenin pathway in human cancer cells

(2014) Katsuhiro Uzawa et al.   Scientific Reports

Metabolomics in Drug Discovery and Development

(2013) D G Robertson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

(2013) Joshua C Denny et al.   NATURE BIOTECHNOLOGY

Rational drug repositioning by medical genetics

(2013) Zhong-Yi Wang et al.   NATURE BIOTECHNOLOGY

Comprehensive Analysis of Transcriptome Variation Uncovers Known and Novel Driver Events in T-Cell Acute Lymphoblastic Leukemia

(2013) Zeynep Kalender Atak et al.   PLoS Genetics

Markers of mitochondrial dysfunction during the diclofenac-induced apoptosis in melanoma cell lines

(2012) Francesco Albano et al.   BIOCHIMIE

Atypical fluoroquinolone gold(III) chelates as potential anticancer agents: Relevance of DNA and protein interactions for their mechanism of action

(2012) Ligiane R. Gouvea et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Unique antineoplastic profile of Saquinavir-NO, a novel NO-derivative of the protease inhibitor Saquinavir, on the in vitro and in vivo tumor formation of A375 human melanoma cells

(2012) MARCO DONIA et al.   ONCOLOGY REPORTS

The effect of tricyclic antidepressants on cutaneous melanoma cell lines and primary cell cultures

(2011) Katharine A. Parker et al.   ANTI-CANCER DRUGS

13. Cancers attributable to solar (ultraviolet) radiation exposure in the UK in 2010

(2011) D M Parkin et al.   BRITISH JOURNAL OF CANCER

Melanogenesis Inhibitory Activity of Two Generic Drugs: Cinnarizine and Trazodone in Mouse B16 Melanoma Cells

(2011) Te-Sheng Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Whole-cell biotransformation assay for investigation of the human drug metabolizing enzyme CYP3A7

(2010) Ina Neunzig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Integrative analysis of the melanoma transcriptome

(2010) M. F. Berger et al.   GENOME RESEARCH

Cytotoxic and immune-sensitizing properties of nitric oxide-modified saquinavir in iNOS-positive human melanoma cells

(2010) Sanja Mijatovic et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effective Melanoma Immunotherapy in Mice by the Skin-Depigmenting Agent Monobenzone and the Adjuvants Imiquimod and CpG

(2010) Jasper G. van den Boorn et al.   PLoS One

Substrates, Inducers, Inhibitors and Structure-Activity Relationships of Human Cytochrome P450 2C9 and Implications in Drug Development

(2009) S.-F. Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis

(2009) Yun-Ru Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Final Version of 2009 AJCC Melanoma Staging and Classification

(2009) Charles M. Balch et al.   JOURNAL OF CLINICAL ONCOLOGY

ErbB receptor tyrosine kinases contribute to proliferation of malignant melanoma cells: inhibition by gefitinib (ZD1839)

(2009) Emelie A. Djerf et al.   MELANOMA RESEARCH

SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions

(2009) Saskia Preissner et al.   NUCLEIC ACIDS RESEARCH

Long-Term Exposure to Zidovudine Delays Cell Cycle Progression, Induces Apoptosis, and Decreases Telomerase Activity in Human Hepatocytes

(2009) Jia-Long Fang et al.   TOXICOLOGICAL SCIENCES

Pharmacological Evaluation of Morphine and Non-opioid Analgesic Adjuvants in a Mouse Model of Skin Cancer Pain

(2008) Tsugunobu Andoh et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN