Drug Repositioning for Diabetes Based on 'Omics' Data Mining

Insulin resistance and cognitive dysfunction

(2015) Lina Ma et al.   CLINICA CHIMICA ACTA

The Furan Fatty Acid Metabolite CMPF Is Elevated in Diabetes and Induces β Cell Dysfunction

(2014) Kacey J. Prentice et al.   Cell Metabolism

Pancreatic Safety of Incretin-Based Drugs — FDA and EMA Assessment

(2014) Amy G. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Computational Drug Repositioning: From Data to Therapeutics

(2013) M R Hurle et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Metabolomics in Drug Discovery and Development

(2013) D G Robertson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Reply to Rational drug repositioning by medical genetics

(2013) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

Rational drug repositioning by medical genetics

(2013) Zhong-Yi Wang et al.   NATURE BIOTECHNOLOGY

Prediction of Drug-Target Interactions for Drug Repositioning Only Based on Genomic Expression Similarity

(2013) Kejian Wang et al.   PLoS Computational Biology

Causal reasoning on biological networks: interpreting transcriptional changes

(2012) Leonid Chindelevitch et al.   BIOINFORMATICS

Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice

(2012) W. Keung et al.   DIABETES

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

(2012) Amélie Bonnefond et al.   NATURE GENETICS

Improving Glucose Metabolism With Resveratrol in a Swine Model of Metabolic Syndrome Through Alteration of Signaling Pathways in the Liver and Skeletal Muscle

(2011) Thomas A. Burgess   ARCHIVES OF SURGERY

Literature mining, ontologies and information visualization for drug repurposing

(2011) C. Andronis et al.   BRIEFINGS IN BIOINFORMATICS

Central Role for Interleukin-2 in Type 1 Diabetes

(2011) M. A. Hulme et al.   DIABETES

DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical–protein interactome

(2011) Heng Luo et al.   NUCLEIC ACIDS RESEARCH

Removing Batch Effects in Analysis of Expression Microarray Data: An Evaluation of Six Batch Adjustment Methods

(2011) Chao Chen et al.   PLoS One

Systematic Drug Repositioning Based on Clinical Side-Effects

(2011) Lun Yang et al.   PLoS One

Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome — Clozapine-Induced Agranulocytosis as a Case Study

(2011) Lun Yang et al.   PLoS Computational Biology

Activation ofN-Methyl-d-aspartate (NMDA) Receptors in the Dorsal Vagal Complex Lowers Glucose Production

(2010) Carol K. L. Lam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylcholinesterase Antagonist Potentiated Insulin Action in Fed but Not Fasted State

(2010) J. Schafer et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Metabonomic Variations in the Drug-Treated Type 2 Diabetes Mellitus Patients and Healthy Volunteers

(2009) Yuqian Bao et al.   JOURNAL OF PROTEOME RESEARCH

Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes

(2009) A. H. Rosengren et al.   SCIENCE

Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation

(2009) Nils Paulmann et al.   PLOS BIOLOGY