Rapamycin Affects Palmitate-Induced Lipotoxicity in Osteoblasts by Modulating Apoptosis and Autophagy

mTOR: A Cellular Regulator Interface in Health and Disease

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LC3-associated phagocytosis at a glance

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Cysteine-rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of rapamycin complex 1 and canonical Wnt signaling

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Marrow Fat—a New Target to Treat Bone Diseases?

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Good, Bad, or Ugly: the Biological Roles of Bone Marrow Fat

(2018) Lakshman Singh et al.   Current Osteoporosis Reports

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

(2017) Thomas Weichhart   GERONTOLOGY

Mechanisms of marrow adiposity and its implications for skeletal health

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Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction

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Postmenopausal Osteoporosis

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Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells

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Autophagy in bone: Self-eating to stay in balance

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mTOR: a pharmacologic target for autophagy regulation

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Role of apoptosis in pathogenesis and treatment of bone-related diseases

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mTORC1 Signaling Promotes Osteoblast Differentiation from Preosteoblasts

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mTOR activation in immature cells of primary nasopharyngeal carcinoma and anti-tumor effect of rapamycin in vitro and in vivo

(2013) Chunguang Yang et al.   CANCER LETTERS

Mechanisms of Palmitate-Induced Lipotoxicity in Human Osteoblasts

(2013) Krishanthi Gunaratnam et al.   ENDOCRINOLOGY

Mechanistic target of rapamycin controls homeostasis of adipogenesis

(2013) Mee-Sup Yoon et al.   JOURNAL OF LIPID RESEARCH

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

WNT signaling in bone homeostasis and disease: from human mutations to treatments

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Mechanisms of palmitate-induced cell death in human osteoblasts

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Regulation Mechanisms and Signaling Pathways of Autophagy

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A study of bone marrow and subcutaneous fatty acid composition in subjects of varying bone mineral density

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Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro

(2009) Alexandre Elbaz et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Rapamycin Promotes the Osteoblastic Differentiation of Human Embryonic Stem Cells by Blocking the mTOR Pathway and Stimulating the BMP/Smad Pathway

(2009) Kyu-Won Lee et al.   STEM CELLS AND DEVELOPMENT

AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast

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