Plasma FGF‐21 and GDF‐15 are elevated in different inherited metabolic diseases and are not diagnostic for mitochondrial disorders

Liver Plays a Major Role in FGF-21 Mediated Glucose Homeostasis

(2018) Mingyao Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Growth Differentiation Factor 15 Predicts Chronic Liver Disease Severity

(2017) Eaum Seok Lee et al.   Gut and Liver

Growth Differentiation Factor–15 and Risk of CKD Progression

(2017) Viji Nair et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease

(2017) Bo Kyung Koo et al.   LIVER INTERNATIONAL

Use of FGF-21 as a Biomarker of Mitochondrial Disease in Clinical Practice

(2017) Alireza Morovat et al.   Journal of Clinical Medicine

Panel of three novel serum markers predicts liver stiffness and fibrosis stages in patients with chronic liver disease

(2017) Marcin Krawczyk et al.   PLoS One

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide, Troponin-T, and Growth-Differentiation Factor 15 in Adult Congenital Heart DiseaseClinical Perspective

(2016) Vivan J.M. Baggen et al.   CIRCULATION

Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease

(2016) Kai C. Wollert et al.   CLINICAL CHEMISTRY

Elevated FGF 21 in myotonic dystrophy type 1 and mitochondrial diseases

(2016) Emese Lovadi et al.   MUSCLE & NERVE

A comparison of current serum biomarkers as diagnostic indicators of mitochondrial diseases

(2016) Ryan L. Davis et al.   NEUROLOGY

GDF-15 Is Elevated in Children with Mitochondrial Diseases and Is Induced by Mitochondrial Dysfunction

(2016) Raquel Montero et al.   PLoS One

Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages

(2015) Elma Aflaki et al.   AGING CELL

Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease

(2015) Gráinne S. Gorman et al.   ANNALS OF NEUROLOGY

Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders

(2015) Shuichi Yatsuga et al.   ANNALS OF NEUROLOGY

Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux

(2015) Mario Ost et al.   FASEB JOURNAL

Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR–YY1–PGC1α pathway

(2015) Kunqian Ji et al.   FREE RADICAL BIOLOGY AND MEDICINE

Circulating Fibroblast Growth Factor 21 Levels Predict Progressive Kidney Disease in Subjects With Type 2 Diabetes and Normoalbuminuria

(2015) C. H. Lee et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases

(2015) Yasunori Fujita et al.   MITOCHONDRION

Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction

(2015) Wenduo Zhang et al.   PLoS One

Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies

(2014) Susana Kalko et al.   BMC GENOMICS

Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress

(2014) Seong Hun Kim et al.   DIABETOLOGIA

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

(2013) Susanne Keipert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The clinical maze of mitochondrial neurology

(2013) Salvatore DiMauro et al.   Nature Reviews Neurology

FGF21 in ataxia patients with spinocerebellar atrophy and mitochondrial disease

(2012) Shih-Li Su et al.   CLINICA CHIMICA ACTA

Fibroblast growth factor-21 serum concentrations are associated with metabolic and hepatic markers in humans

(2012) Susan Kralisch et al.   JOURNAL OF ENDOCRINOLOGY

Clinical and molecular features of mitochondrial DNA depletion due to mutations in deoxyguanosine kinase

(2008) D. P. Dimmock et al.   HUMAN MUTATION

The in-depth evaluation of suspected mitochondrial disease

(2008) Richard H. Haas et al.   MOLECULAR GENETICS AND METABOLISM