Use of FGF-21 as a Biomarker of Mitochondrial Disease in Clinical Practice

Myopathology of Adult and Paediatric Mitochondrial Diseases

(2017) Rahul Phadke   Journal of Clinical Medicine

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

Lactate induces FGF21 expression in adipocytes through a p38-MAPK pathway

(2016) Y. Jeanson et al.   BIOCHEMICAL JOURNAL

FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders

(2016) Jenni M. Lehtonen et al.   NEUROLOGY

A comparison of current serum biomarkers as diagnostic indicators of mitochondrial diseases

(2016) Ryan L. Davis et al.   NEUROLOGY

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

(2016) Mario Ost et al.   Molecular Metabolism

Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease

(2015) Gráinne S. Gorman et al.   ANNALS OF NEUROLOGY

Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR–YY1–PGC1α pathway

(2015) Kunqian Ji et al.   FREE RADICAL BIOLOGY AND MEDICINE

FGF21 Response to Critical Illness: Effect of Blood Glucose Control and Relation With Cellular Stress and Survival

(2015) Steven E. Thiessen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response

(2015) Sebastien Michel et al.   MITOCHONDRION

Fructose ingestion acutely stimulates circulating FGF21 levels in humans

(2015) Jody R. Dushay et al.   Molecular Metabolism

FGF21 and Cardiac Physiopathology

(2015) Anna Planavila et al.   Frontiers in Endocrinology

FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling

(2014) Francesc Ribas et al.   BIOCHEMICAL JOURNAL

Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies

(2014) Susana Kalko et al.   BMC GENOMICS

Fibroblast growth factor 21 protects the heart from oxidative stress

(2014) Anna Planavila et al.   CARDIOVASCULAR RESEARCH

Tissue-Specific Loss of DARS2 Activates Stress Responses Independently of Respiratory Chain Deficiency in the Heart

(2014) Sukru Anil Dogan et al.   Cell Metabolism

Serum FGF21 levels in adult m.3243A>G carriers: Clinical implications

(2014) S. Koene et al.   NEUROLOGY

Fibroblast Growth Factor 21 Improves Insulin Sensitivity and Synergizes with Insulin in Human Adipose Stem Cell-Derived (hASC) Adipocytes

(2014) Darwin V. Lee et al.   PLoS One

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron–sulfur cluster depletion in human skeletal muscle

(2013) Daniel R. Crooks et al.   HUMAN MOLECULAR GENETICS

Fibroblast growth factor 21 is a sensitive biomarker of mitochondrial disease

(2013) R. L. Davis et al.   NEUROLOGY

Stressed Liver and Muscle Call on Adipocytes with FGF21

(2013) Yongde Luo et al.   Frontiers in Endocrinology

Fibroblast Growth Factor 21 as an emerging metabolic regulator: clinical perspectives

(2012) Y. C. Woo et al.   CLINICAL ENDOCRINOLOGY

High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: A 3-year prospective study in China

(2012) Huating Li et al.   JOURNAL OF HEPATOLOGY

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity

(2011) Fredirick L. Mashili et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation

(2011) Eva Rath et al.   GUT

FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study

(2011) Anu Suomalainen et al.   LANCET NEUROLOGY

Circulating FGF21 Levels Are Progressively Increased from the Early to End Stages of Chronic Kidney Diseases and Are Associated with Renal Function in Chinese

(2011) Zhuofeng Lin et al.   PLoS One

Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

(2010) Jody Dushay et al.   GASTROENTEROLOGY

Mitochondrial myopathy induces a starvation-like response

(2010) Henna Tyynismaa et al.   HUMAN MOLECULAR GENETICS

Liver Fat But Not Other Adiposity Measures Influence Circulating FGF21 Levels in Healthy Young Adult Twins

(2010) Henna Tyynismaa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fibroblast Growth Factor-21 Is Induced in Human Skeletal Muscles by Hyperinsulinemia

(2009) Pernille Hojman et al.   DIABETES

Circulating Fibroblast Growth Factor 21 Is Induced by Peroxisome Proliferator-Activated Receptor Agonists But Not Ketosis in Man

(2009) Constantinos Christodoulides et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Abnormal growth in mitochondrial disease

(2008) S Wolny et al.   ACTA PAEDIATRICA