Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance

NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells

(2012) Keiko Matsui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT1 is dispensable for function of hematopoietic stem cells in adult mice

(2012) V. Leko et al.   BLOOD

Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita

(2012) F. Beier et al.   BLOOD

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage

(2012) Jianwei Wang et al.   CELL

Regulation of SIRT1 activity by genotoxic stress

(2012) J. Yuan et al.   GENES & DEVELOPMENT

Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function

(2012) Juan I. Garaycoechea et al.   NATURE

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells

(2012) Z Wang et al.   ONCOGENE

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

(2011) H. Yuan et al.   BLOOD

A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay

(2011) K. Biswas et al.   BLOOD

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

(2011) Heather M. O'Hagan et al.   CANCER CELL

Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin

(2011) Lu Lu et al.   CELL RESEARCH

Hematopoietic Stem Cells: Transcriptional Regulation, Ex Vivo Expansion and Clinical Application

(2011) R. Aggarwal et al.   CURRENT MOLECULAR MEDICINE

Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment

(2011) Tony Peled et al.   EXPERIMENTAL HEMATOLOGY

Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitors

(2011) S. He et al.   GENES & DEVELOPMENT

Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

(2011) Brad Dykstra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

(2011) Sanjeev Shukla et al.   NATURE

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse

(2010) X. Ou et al.   BLOOD

SIRT1 contributes to telomere maintenance and augments global homologous recombination

(2010) Jose A. Palacios et al.   JOURNAL OF CELL BIOLOGY

Sirtuin 1 regulation of developmental genes during differentiation of stem cells

(2010) V. Calvanese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

(2010) I. Beerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balancing dormant and self-renewing hematopoietic stem cells

(2009) Anne Wilson et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Aging in the lympho-hematopoietic stem cell compartment

(2009) Hartmut Geiger et al.   TRENDS IN IMMUNOLOGY

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization

(2008) Myung-Kwan Han et al.   Cell Stem Cell

Cytokines regulating hematopoietic stem cell function

(2008) Cheng C Zhang et al.   CURRENT OPINION IN HEMATOLOGY

DNA repair is crucial for maintaining hematopoietic stem cell function

(2008) Laura J. Niedernhofer   DNA REPAIR

SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity

(2008) Swami R. Narala et al.   MOLECULAR BIOLOGY OF THE CELL

Id1 immortalizes hematopoietic progenitors in vitro and promotes a myeloproliferative disease in vivo

(2008) H C Suh et al.   ONCOGENE