Protection against diabetic cardiomyopathy is achieved using a combination of sulforaphane and zinc in type 1 diabetic OVE26 mice

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

(2018) N.H. Cho et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line

(2018) Małgorzata Milczarek et al.   FOOD AND CHEMICAL TOXICOLOGY

Protection by dimethyl fumarate against diabetic cardiomyopathy in type 1 diabetic mice likely via activation of nuclear factor erythroid-2 related factor 2

(2018) Xinyue Hu et al.   TOXICOLOGY LETTERS

Long-Term Zinc Supplementation Improves Liver Function and Decreases the Risk of Developing Hepatocellular Carcinoma

(2018) Atsushi Hosui et al.   Nutrients

Intermittent hypoxia-induced cardiomyopathy and its prevention by Nrf2 and metallothionein

(2017) Shanshan Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Combination cisplatin and sulforaphane treatment reduces proliferation, invasion, and tumor formation in epidermal squamous cell carcinoma

(2017) Candace Kerr et al.   MOLECULAR CARCINOGENESIS

Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells

(2017) Yoon-Jin Lee et al.   Molecular Medicine Reports

Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency

(2017) Jed W. Fahey et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Type 1 diabetes incidence and prevalence trends in a cohort of Canadian children and youth

(2017) Danya A Fox et al.   PEDIATRIC DIABETES

Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity

(2017) Mostafa Wanees Ahmed El husseny et al.   Journal of Diabetes Research

Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy

(2016) Junlian Gu et al.   DIABETES

Fucoidan reduces oxidative stress by regulating the gene expression of HO-1 and SOD-1 through the Nrf2/ERK signaling pathway in HaCaT cells

(2016) Min Ju Ryu et al.   Molecular Medicine Reports

Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician’s Expectation Be Matched by the Reality?

(2016) Christine A. Houghton et al.   Oxidative Medicine and Cellular Longevity

Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane

(2016) Li Yang et al.   SEMINARS IN ONCOLOGY

Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice

(2016) Zheng Xu et al.   Scientific Reports

Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial

(2016) Robert A. Wise et al.   PLoS One

Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2

(2015) Hao Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis

(2015) Patrizia Zavattari et al.   HEPATOLOGY

The role of Nrf2 in oxidative stress-induced endothelial injuries

(2015) B. Chen et al.   JOURNAL OF ENDOCRINOLOGY

Synergy between sulforaphane and selenium in protection against oxidative damage in colonic CCD841 cells

(2015) Yichong Wang et al.   NUTRITION RESEARCH

Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation

(2015) Yang Bai et al.   Oxidative Medicine and Cellular Longevity

Combination of Zinc and All-Trans Retinoic Acid Promotes Protection against Listeria monocytogenes Infection

(2015) Yussaira Castillo et al.   PLoS One

Zinc treatment prevents type 1 diabetes-induced hepatic oxidative damage, endoplasmic reticulum stress, and cell death, and even prevents possible steatohepatitis in the OVE26 mouse model: Important role of metallothionein

(2015) Tingting Liang et al.   TOXICOLOGY LETTERS

Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function

(2014) Yonggang Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Zinc Supplementation Alleviates Diabetic Peripheral Neuropathy by Inhibiting Oxidative Stress and Upregulating Metallothionein in Peripheral Nerves of Diabetic Rats

(2014) Fangyao liu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Catalase Overexpression Prevents Nuclear Factor Erythroid 2-Related Factor 2 Stimulation of Renal Angiotensinogen Gene Expression, Hypertension, and Kidney Injury in Diabetic Mice

(2014) S. Abdo et al.   DIABETES

Molecular mechanisms of diabetic cardiomyopathy

(2014) Heiko Bugger et al.   DIABETOLOGIA

Zinc is essential for the transcription function of Nrf2 in human renal tubule cellsin vitroand mouse kidneyin vivounder the diabetic condition

(2014) Bing Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Zinc rescue of Akt2 gene deletion-linked murine cardiac dysfunction and pathological changes is metallothionein-dependent

(2014) Weixia Sun et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sulforaphane Attenuation of Type 2 Diabetes-Induced Aortic Damage Was Associated with the Upregulation of Nrf2 Expression and Function

(2014) Yonggang Wang et al.   Oxidative Medicine and Cellular Longevity

Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways

(2014) Karina Huynh et al.   PHARMACOLOGY & THERAPEUTICS

SPBP Is a Sulforaphane Induced Transcriptional Coactivator of NRF2 Regulating Expression of the Autophagy Receptor p62/SQSTM1

(2014) Sagar Ramesh Darvekar et al.   PLoS One

The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome

(2014) Zhiguo Zhang et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function

(2014) Xin Jiang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage

(2014) Quan Liu et al.   Journal of Diabetes Investigation

Standards of Medical Care in Diabetes--2014

(2013)   DIABETES CARE

Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation

(2013) Seungha Hyeon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation

(2013) Yang Bai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A systematic review and meta-analysis of the use of oral zinc in the treatment of hepatic encephalopathy

(2013) Norberto C Chavez-Tapia et al.   Nutrition Journal

Sulforaphane: translational research from laboratory bench to clinic

(2013) Christine A Houghton et al.   NUTRITION REVIEWS

Prevention of Diabetic Complications by Activation of Nrf2: Diabetic Cardiomyopathy and Nephropathy

(2012) Bing Li et al.   Experimental Diabetes Research

Impact of Thermal Processing on Sulforaphane Yield from Broccoli (Brassica oleracea L. ssp. italica)

(2012) Grace C. Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of zinc supplementation on type 2 diabetes parameters and liver metallothionein expressions in Wistar rats

(2012) Xue Wang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Prevention of Diabetic Nephropathy by Sulforaphane: Possible Role of Nrf2 Upregulation and Activation

(2012) Wenpeng Cui et al.   Oxidative Medicine and Cellular Longevity

Glucosinolates and isothiocyanates in health and disease

(2012) Albena T. Dinkova-Kostova et al.   TRENDS IN MOLECULAR MEDICINE

Genetics of Type 1 Diabetes

(2011) A. K. Steck et al.   CLINICAL CHEMISTRY

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

(2011) Y. Tan et al.   DIABETES

Complications of Type 1 Diabetes

(2010) L. Yvonne Melendez-Ramirez et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Epidemiology of Type 1 Diabetes

(2010) David M. Maahs et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression

(2010) James W. Kaspar et al.   FASEB JOURNAL

Statistics and bioinformatics in nutritional sciences: analysis of complex data in the era of systems biology☆

(2010) Wenjiang J. Fu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice

(2010) Yuguang Zhao et al.   TOXICOLOGY LETTERS

Oxidative Stress, Diabetes, and Diabetic Complications

(2009) Wei Wei et al.   HEMOGLOBIN

Dietary Sulforaphane, a Histone Deacetylase Inhibitor for Cancer Prevention

(2009) Emily Ho et al.   JOURNAL OF NUTRITION

Zinc supplementation for the treatment or prevention of disease: Current status and future perspectives

(2008) Hajo Haase et al.   EXPERIMENTAL GERONTOLOGY

Bioavailability and Kinetics of Sulforaphane in Humans after Consumption of Cooked versus Raw Broccoli

(2008) Martijn Vermeulen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A model for diabetic nephropathy: Advantages of the inducible cAMP early repressor transgenic mouse over the streptozotocin-induced diabetic mouse

(2008) Akari Inada et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

(2008) Xiaoqing He et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Metallothionein Suppresses Angiotensin II–Induced Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation, Nitrosative Stress, Apoptosis, and Pathological Remodeling in the Diabetic Heart

(2008) Guihua Zhou et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Podocyte-Specific Overexpression of the Antioxidant Metallothionein Reduces Diabetic Nephropathy

(2008) S. Zheng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY