Activin signaling as an emerging target for therapeutic interventions

Receptor expression modulates the specificity of transforming growth factor-β signaling pathways

(2009) Masaru Murakami et al.   GENES TO CELLS

Pin1 Down-regulates Transforming Growth Factor-β (TGF-β) Signaling by Inducing Degradation of Smad Proteins

(2009) Ayako Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming Growth Factor β Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

(2009) Katharine H. Wrighton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease

(2009) Louise R. Rodino-Klapac et al.   MUSCLE & NERVE

Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice

(2008) David L. Allen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic β-cells

(2008) Rie Watanabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of TGF-β family signaling by E3 ubiquitin ligases

(2008) Yasumichi Inoue et al.   CANCER SCIENCE

Transforming growth factor-β signaling at the tumor-bone interface promotes mammary tumor growth and osteoclast activation

(2008) Mitsuru Futakuchi et al.   CANCER SCIENCE

NANOG Is a Direct Target of TGFβ/Activin-Mediated SMAD Signaling in Human ESCs

(2008) Ren-He Xu et al.   Cell Stem Cell

Smad2 functions as a co-activator of canonical Wnt/β-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300

(2008) Morihisa Hirota et al.   CELLULAR SIGNALLING

Follistatin Suppresses the Production of Experimental Multiple-Organ Metastasis by Small Cell Lung Cancer Cells in Natural Killer Cell-Depleted SCID Mice

(2008) H. Ogino et al.   CLINICAL CANCER RESEARCH

Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women

(2008) D. S. Hittel et al.   DIABETES

TGFβ-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch

(2008) Irwin M Liu et al.   EMBO JOURNAL

Signal Transduction Pathway through Activin Receptors as a Therapeutic Target of Musculoskeletal Diseases and Cancer

(2008) Kunihiro TSUCHIDA et al.   ENDOCRINE JOURNAL

AAV-dependent targeting of myostatin function: Follistatin strikes back at muscular dystrophy

(2008) C Colussi et al.   GENE THERAPY

Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle mass

(2008) N Kinouchi et al.   GENE THERAPY

Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy

(2008) Ferrill F. Rose et al.   HUMAN MOLECULAR GENETICS

The Structure of FSTL3·Activin A Complex

(2008) Robin Stamler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Novel Pool of Extracellular Pro-myostatin in Skeletal Muscle

(2008) Sarah B. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myostatin Directly Regulates Skeletal Muscle Fibrosis

(2008) Zhao Bo Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activin-A, Transforming Growth Factor-β, and Myostatin Signaling Pathway in Experimental Dilated Cardiomyopathy

(2008) Maryam Mahmoudabady et al.   JOURNAL OF CARDIAC FAILURE

Proteomic Identification and Functional Validation of Activins and Bone Morphogenetic Protein 11 as Candidate Novel Muscle Mass Regulators

(2008) Tatyana A. Souza et al.   MOLECULAR ENDOCRINOLOGY

Deficiency of Growth Differentiation Factor 3 Protects against Diet-Induced Obesity by Selectively Acting on White Adipose

(2008) Joseph J. Shen et al.   MOLECULAR ENDOCRINOLOGY

Activin tunes GABAergic neurotransmission and modulates anxiety-like behavior

(2008) F Zheng et al.   MOLECULAR PSYCHIATRY

The type I TGF-β receptor is covalently modified and regulated by sumoylation

(2008) Jong Seok Kang et al.   NATURE CELL BIOLOGY

BMP type I receptor inhibition reduces heterotopic ossification

(2008) Paul B Yu et al.   NATURE MEDICINE

Activin induces long-lasting N-methyl-d-aspartate receptor activation via scaffolding PDZ protein activin receptor interacting protein 1

(2008) A. Kurisaki et al.   NEUROSCIENCE

Activin in the Brain Modulates Anxiety-Related Behavior and Adult Neurogenesis

(2008) Hiroshi Ageta et al.   PLoS One

A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity

(2008) R. S. Pearsall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity

(2008) O. Andersson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential new drug targets for osteoporosis

(2008) Chad Deal   Nature clinical practice. Rheumatology

Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice

(2007) Masashi Nakatani et al.   FASEB JOURNAL