Neurodegenerative disorders and sterile inflammation: lessons from a Drosophila model

Innate Immunity and Neurodegeneration

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Inflammation, a significant player of Ataxia–Telangiectasia pathogenesis?

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Inflammaging: a new immune–metabolic viewpoint for age-related diseases

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Drosophila as a Model to Study Brain Innate Immunity in Health and Disease

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Neurodegenerative diseases: The immunological perspective

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Glial Draper Rescues Aβ Toxicity in aDrosophilaModel of Alzheimer's Disease

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Yorkie Regulates Neurodegeneration Through Canonical Pathway and Innate Immune Response

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NF-κB Immunity in the Brain Determines Fly Lifespan in Healthy Aging and Age-Related Neurodegeneration

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The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases

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Amyotrophic lateral sclerosis

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Parkinson disease

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MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

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Ageing, neurodegeneration and brain rejuvenation

(2016) Tony Wyss-Coray   NATURE

Ataxia telangiectasia: a review

(2016) Cynthia Rothblum-Oviatt et al.   Orphanet Journal of Rare Diseases

Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein

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An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment

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Traumatic brain injuries

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TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

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Drosophilaas anIn VivoModel for Human Neurodegenerative Disease

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The Role of the Immune System in Triplet Repeat Expansion Diseases

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Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

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Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction

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Drosophilaas anIn VivoModel for Human Neurodegenerative Disease

(2015) Leeanne McGurk et al.   GENETICS

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration

(2014) Lihong Zhan et al.   HUMAN MOLECULAR GENETICS

The Innate Immune Response Transcription Factor Relish Is Necessary for Neurodegeneration in aDrosophilaModel of Ataxia-Telangiectasia

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Proinflammatory Cytokines, Aging, and Age-Related Diseases

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CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

A Drosophila model of closed head traumatic brain injury

(2013) R. J. Katzenberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila

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Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila

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Negative Regulation by Amidase PGRPs Shapes the Drosophila Antibacterial Response and Protects the Fly from Innocuous Infection

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Mutant superoxide dismutase 1-induced IL-1  accelerates ALS pathogenesis

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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

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Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants

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Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

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A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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The Toll→NFκB Signaling Pathway Mediates the Neuropathological Effects of the Human Alzheimer's Aβ42 Polypeptide in Drosophila

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