Pathway-Centric Structure-Based Multi-Target Compound Screening for Anti-Virulence Drug Repurposing

Extensively and pan-drug resistant Pseudomonas aeruginosa keratitis: clinical features, risk factors, and outcome

(2015) Merle Fernandes et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

ZINC 15 – Ligand Discovery for Everyone

(2015) Teague Sterling et al.   Journal of Chemical Information and Modeling

BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers

(2015) Z. Tang et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of quorum sensing and biofilm formation in Vibrio harveyi by 4-fluoro-DPD; a novel potent inhibitor of AI-2 signalling

(2014) Manikandan Kadirvel et al.   CHEMICAL COMMUNICATIONS

Preliminary results of a novel quorum sensing inhibitor against pneumococcal infection and biofilm formation with special interest to otitis media and cochlear implantation

(2014) Raşit Cevizci et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

The Antitumor Activity of Meisoindigo against Human Colorectal Cancer HT-29 CellsIn VitroandIn Vivo

(2014) Zuo Mingxin et al.   JOURNAL OF CHEMOTHERAPY

Aspirin is an efficient inhibitor of quorum sensing, virulence and toxins in Pseudomonas aeruginosa

(2014) Somaia A. El-Mowafy et al.   MICROBIAL PATHOGENESIS

Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity

(2014) Melissa Starkey et al.   PLoS Pathogens

Antivirulence activity of azithromycin in Pseudomonas aeruginosa

(2014) Francesco Imperi et al.   Frontiers in Microbiology

Structure of type II dehydroquinase fromPseudomonas aeruginosa

(2014) Scott Reiling et al.   Acta Crystallographica Section F-Structural Biology Communications

Synthesis of (R)-norbgugaine and its potential as quorum sensing inhibitor against Pseudomonas aeruginosa

(2013) Mahesh S. Majik et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation

(2013) C. T. O'Loughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)

(2013) Aravindan Ilangovan et al.   PLoS Pathogens

Food as a Source for Quorum Sensing Inhibitors: Iberin from Horseradish Revealed as a Quorum Sensing Inhibitor of Pseudomonas aeruginosa

(2012) Tim Holm Jakobsen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Raloxifene attenuates Pseudomonas aeruginosa pyocyanin production and virulence

(2012) Shannan J. Ho Sui et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

A new quorum-sensing inhibitor attenuates virulence and decreases antibiotic resistance in Pseudomonas aeruginosa

(2012) Yu-Xiang Yang et al.   JOURNAL OF MICROBIOLOGY

Race against time to develop new antibiotics

(2011) . .   BULLETIN OF THE WORLD HEALTH ORGANIZATION

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors

(2009) Li Xie et al.   PLoS Computational Biology