Targeting Quorum Sensing: High-Throughput Screening to Identify Novel LsrK Inhibitors

DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance

(2019) Silvia Stotani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review

(2019) Biswanath Dinda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-biofilm and Anti-Virulence Efficacy of Celastrol Against Stenotrophomonas maltophilia

(2018) Hye-Rim Kim et al.   International Journal of Medical Sciences

Multidrug efflux pumps: structure, function and regulation

(2018) Dijun Du et al.   NATURE REVIEWS MICROBIOLOGY

Quorum-Sensing Systems as Targets for Antivirulence Therapy

(2018) Tom Defoirdt   TRENDS IN MICROBIOLOGY

STRUCTURE-BASED VIRTUAL SCREENING OF LSRK KINASE INHIBITORS TO TARGET QUORUM SENSING

(2018) Prasanthi Medarametla et al.   ChemMedChem

Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections

(2018) Matthew B Calvert et al.   Beilstein Journal of Organic Chemistry

Miniaturized whole-cell bacterial bioreporter assay for identification of quorum sensing interfering compounds

(2018) Polina Ilina et al.   JOURNAL OF MICROBIOLOGICAL METHODS

A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

(2018) Silvia Stotani et al.   MOLECULES

Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

(2017) Seth W. Dickey et al.   NATURE REVIEWS DRUG DISCOVERY

Gallium-Protoporphyrin IX Inhibits Pseudomonas aeruginosa Growth by Targeting Cytochromes

(2017) Sarah Hijazi et al.   Frontiers in Cellular and Infection Microbiology

The identification of the metabolites of chlorothalonil in zebrafish ( Danio rerio ) and their embryo toxicity and endocrine effects at environmentally relevant levels

(2016) Quan Zhang et al.   ENVIRONMENTAL POLLUTION

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

(2016) Laetitia J. Martin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes

(2016) Abdul Haseeb et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Quorum sensing signal–response systems in Gram-negative bacteria

(2016) Kai Papenfort et al.   NATURE REVIEWS MICROBIOLOGY

One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists

(2015) Johannes Schiebel et al.   ChemMedChem

Competition Studies Confirm Two Major Barriers That Can Preclude the Spread of Resistance to Quorum-Sensing Inhibitors in Bacteria

(2014) Joseph P. Gerdt et al.   ACS Chemical Biology

Targeting virulence: can we make evolution-proof drugs?

(2014) Richard C. Allen et al.   NATURE REVIEWS MICROBIOLOGY

Lack of Neuroprotective Effect of Celastrol Under Conditions of Proteasome Inhibition by Lactacystin in In Vitro and In Vivo Studies: Implications for Parkinson’s Disease

(2014) Jolanta Konieczny et al.   NEUROTOXICITY RESEARCH

The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria

(2013) Ryan P. Lamers et al.   PLoS One

Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control

(2013) S. T. Rutherford et al.   Cold Spring Harbor Perspectives in Medicine

Oral bioavailability and gender-related pharmacokinetics of celastrol following administration of pure celastrol and its related tablets in rats

(2012) Jun Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

C4-Alkoxy-HPD: A Potent Class of Synthetic Modulators Surpassing Nature in AI-2 Quorum Sensing

(2012) Kyoji Tsuchikama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antioxidant and Antimicrobial Properties of Some Lichens and Their Constituents

(2011) Marijana Kosanić et al.   JOURNAL OF MEDICINAL FOOD

Chlorothalonil degradation by Ochrobactrum lupini strain TP-D1 and identification of its metabolites

(2010) Xiu-Zhen Shi et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Cross Species Quorum Quenching Using a Native AI-2 Processing Enzyme

(2009) Varnika Roy et al.   ACS Chemical Biology