The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 14, Pages 3602
Publisher
MDPI AG
Online
2019-07-23
DOI
10.3390/ijms20143602
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Expression of Proteolytic Enzymes by Small Cell Lung Cancer Circulating Tumor Cell Lines
- (2019) Barbara Rath et al. Cancers
- Cysteine Cathepsins and their Extracellular Roles: Shaping the Microenvironment
- (2019) Eva Vidak et al. Cells
- Cystatins in cancer progression: More than just cathepsin inhibitors
- (2019) Barbara Breznik et al. BIOCHIMIE
- Cathepsin L promotes ionizing radiation-induced U251 glioma cell migration and invasion through regulating the GSK-3β/CUX1 pathway
- (2018) Yao Fei et al. CELLULAR SIGNALLING
- Carrier-free nanoparticles of cathepsin B-cleavable peptide-conjugated doxorubicin prodrug for cancer targeting therapy
- (2018) Man Kyu Shim et al. JOURNAL OF CONTROLLED RELEASE
- Cathepsin nanofiber substrates as potential agents for targeted drug delivery
- (2017) Yael Ben-Nun et al. JOURNAL OF CONTROLLED RELEASE
- Elevated expression of CST1 promotes breast cancer progression and predicts a poor prognosis
- (2017) Da-nian Dai et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion
- (2017) Hendrika M Duivenvoorden et al. JOURNAL OF PATHOLOGY
- Lysosomes as Oxidative Targets for Cancer Therapy
- (2017) Rebecca F. Dielschneider et al. Oxidative Medicine and Cellular Longevity
- Clinical significance of serum cathepsin B and cystatin C levels and their ratio in the prognosis of patients with esophageal cancer
- (2017) Yan Yan et al. OncoTargets and Therapy
- Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation
- (2017) Sang-Seok Oh et al. Cell Death & Disease
- Cystatin A suppresses tumor cell growth through inhibiting epithelial to mesenchymal transition in human lung cancer
- (2017) Yunxia Ma et al. Oncotarget
- Cathepsins in digestive cancers
- (2017) Siyuan Chen et al. Oncotarget
- Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis
- (2017) Benny Zhitomirsky et al. Oncotarget
- Cystatin C deficiency suppresses tumor growth in a breast cancer model through decreased proliferation of tumor cells
- (2017) Janja Završnik et al. Oncotarget
- Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells
- (2016) Mei-ling Han et al. ACTA PHARMACOLOGICA SINICA
- Tissue Levels of Stefin A and Stefin B in Hepatocellular Carcinoma
- (2016) Yang-Yuan Lin et al. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
- Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells
- (2016) Tripti Tamhane et al. BIOCHIMIE
- Role of autophagy and lysosomal drug sequestration in acquired resistance to doxorubicin in MCF-7 cells
- (2016) Baoqing Guo et al. BMC CANCER
- Lysosomes in cancer—living on the edge (of the cell)
- (2016) Saara Hämälistö et al. CURRENT OPINION IN CELL BIOLOGY
- Autophagic lysosomal reformation depends on mTOR reactivation in H2O2-induced autophagy
- (2016) Jiqian Zhang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Mechanisms and functions of lysosome positioning
- (2016) Jing Pu et al. JOURNAL OF CELL SCIENCE
- Overexpression of Cathepsin L is associated with chemoresistance and invasion of epithelial ovarian cancer
- (2016) Hongying Sui et al. Oncotarget
- Cysteine Proteases: Modes of Activation and Future Prospects as Pharmacological Targets
- (2016) Sonia Verma et al. Frontiers in Pharmacology
- Cathepsin S: therapeutic, diagnostic, and prognostic potential
- (2015) Richard D.A. Wilkinson et al. BIOLOGICAL CHEMISTRY
- Selective autophagy: Lysophagy
- (2015) Junya Hasegawa et al. METHODS
- Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factor-β-mediated epithelial-mesenchymal transition
- (2015) QINGQING ZHANG et al. ONCOLOGY REPORTS
- p53 directly activates cystatin D/CST5 to mediate mesenchymal-epithelial transition: a possible link to tumor suppression by vitamin D3
- (2015) Sabine Hünten et al. Oncotarget
- Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance
- (2015) Benny Zhitomirsky et al. Oncotarget
- Cathepsin B Mediates the pH-Dependent Proinvasive Activity of Tumor-Shed Microvesicles
- (2015) Ilaria Giusti et al. NEOPLASIA
- Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins
- (2015) Jennifer M Rothberg et al. NEOPLASIA
- Cysteine cathepsins and extracellular matrix degradation
- (2014) Marko Fonović et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF-β signaling pathway
- (2014) XINGXING WANG et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Regulation of TGF-β1-driven Differentiation of Human Lung Fibroblasts
- (2014) Mariana Kasabova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Overexpression of cysteine cathepsin L is a marker of invasion and metastasis in ovarian cancer
- (2014) WEI ZHANG et al. ONCOLOGY REPORTS
- Characterization of cathepsin X in colorectal cancer development and progression
- (2014) Doerthe Jechorek et al. PATHOLOGY RESEARCH AND PRACTICE
- Signaling mechanisms of the epithelial-mesenchymal transition
- (2014) D. M. Gonzalez et al. Science Signaling
- Cathepsin K-mediated notch1 activation contributes to neovascularization in response to hypoxia
- (2014) Haiying Jiang et al. Nature Communications
- Cysteine Cathepsins as Regulators of the Cytotoxicity of NK and T Cells
- (2014) Milica Perišić Nanut et al. Frontiers in Immunology
- Drug Resistance in Cancer: An Overview
- (2014) Genevieve Housman et al. Cancers
- Acidity Generated by the Tumor Microenvironment Drives Local Invasion
- (2013) V. Estrella et al. CANCER RESEARCH
- Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells
- (2013) Dhivya R. Sudhan et al. CLINICAL & EXPERIMENTAL METASTASIS
- Autophagy and cell death
- (2013) Tohru Yonekawa et al. Essays in Biochemistry
- Cathepsin B as a cancer target
- (2013) Christopher S Gondi et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Lysosomal exocytosis and caspase-8-mediated apoptosis in UVA-irradiated keratinocytes
- (2013) Hanna Appelqvist et al. JOURNAL OF CELL SCIENCE
- Cathepsin B as a potential prognostic and therapeutic marker for human lung squamous cell carcinoma
- (2013) Fengming Gong et al. Molecular Cancer
- Thymoquinone Inhibits Autophagy and Induces Cathepsin-Mediated, Caspase-Independent Cell Death in Glioblastoma Cells
- (2013) Ira O. Racoma et al. PLoS One
- Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer
- (2013) B Liu et al. Cell Death & Disease
- VEGF and Notch in Tip and Stalk Cell Selection
- (2013) R. Blanco et al. Cold Spring Harbor Perspectives in Medicine
- Cystatins in Immune System
- (2013) Špela Magister et al. Journal of Cancer
- Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer
- (2012) N. P. Withana et al. CANCER RESEARCH
- Global secretome analysis identifies novel mediators of bone metastasis
- (2012) Mario Andres Blanco et al. CELL RESEARCH
- Role for Cysteine Protease Cathepsins in Heart Disease
- (2012) Xian Wu Cheng et al. CIRCULATION
- Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells
- (2012) Špela Magister et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- The regulation of cysteine cathepsins and cystatins in human gliomas
- (2012) Boris Gole et al. INTERNATIONAL JOURNAL OF CANCER
- Inhibitors of cathepsins B and L induce autophagy and cell death in neuroblastoma cells
- (2012) Donna M. Cartledge et al. INVESTIGATIONAL NEW DRUGS
- Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth
- (2012) Mélanie Bruchard et al. NATURE MEDICINE
- Inhibition of Glioma Cell Lysosome Exocytosis Inhibits Glioma Invasion
- (2012) Yu Liu et al. PLoS One
- Protease-Activated Drug Development
- (2012) Ki Young Choi et al. Theranostics
- Lysosomes and lysosomal cathepsins in cell death
- (2011) Urška Repnik et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Cysteine cathepsins: From structure, function and regulation to new frontiers
- (2011) Vito Turk et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas
- (2011) Roberta E. Burden et al. BIOCHIMIE
- Lysosomal Sequestration of Sunitinib: A Novel Mechanism of Drug Resistance
- (2011) K. J. Gotink et al. CLINICAL CANCER RESEARCH
- Overexpression of Cathepsin Z Contributes to Tumor Metastasis by Inducing Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma
- (2011) Jian Wang et al. PLoS One
- Regulation of apoptosis-associated lysosomal membrane permeabilization
- (2010) Ann-Charlotte Johansson et al. APOPTOSIS
- Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer
- (2010) Vasilena Gocheva et al. BIOLOGICAL CHEMISTRY
- Cathepsin B Expression and Survival in Colon Cancer: Implications for Molecular Detection of Neoplasia
- (2010) A. T. Chan et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Induction of cell death in neuroblastoma by inhibition of cathepsins B and L
- (2010) Rita Colella et al. CANCER LETTERS
- Combating apoptosis and multidrug resistant cancers by targeting lysosomes
- (2010) Line Groth-Pedersen et al. CANCER LETTERS
- Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts
- (2010) N. D. Staudt et al. HAEMATOLOGICA
- Specialized roles for cysteine cathepsins in health and disease
- (2010) Jochen Reiser et al. JOURNAL OF CLINICAL INVESTIGATION
- Autophagy: cellular and molecular mechanisms
- (2010) Danielle Glick et al. JOURNAL OF PATHOLOGY
- Antibody Targeting of Cathepsin S Inhibits Angiogenesis and Synergistically Enhances Anti-VEGF
- (2010) Claire Ward et al. PLoS One
- Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice
- (2010) L. Sevenich et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cystatin M expression is reduced in gastric carcinoma and is associated with promoter hypermethylation
- (2009) Xiaobing Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
- (2009) I. F. Robey et al. CANCER RESEARCH
- Upregulation of the cysteine protease inhibitor, cystatin SN, contributes to cell proliferation and cathepsin inhibition in gastric cancer
- (2009) Eun Hwa Choi et al. CLINICA CHIMICA ACTA
- Antibody-Mediated Inhibition of Cathepsin S Blocks Colorectal Tumor Invasion and Angiogenesis
- (2009) R. E. Burden et al. CLINICAL CANCER RESEARCH
- Cystatin B As a Tissue and Urinary Biomarker of Bladder Cancer Recurrence and Disease Progression
- (2009) A. S. Feldman et al. CLINICAL CANCER RESEARCH
- Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation
- (2009) Dora Cavallo-Medved et al. EXPERIMENTAL CELL RESEARCH
- Epigenetic regulation of cystatins in cancer
- (2009) Ashley et al. Frontiers in Bioscience-Landmark
- Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer
- (2009) Shane Sullivan et al. INTERNATIONAL JOURNAL OF CANCER
- Tumor angiogenesis and novel antiangiogenic strategies
- (2009) Michael S. Gordon et al. INTERNATIONAL JOURNAL OF CANCER
- Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells
- (2009) Silvia ρlvarez-Díaz et al. JOURNAL OF CLINICAL INVESTIGATION
- Intra- versus extracellular effects of microglia-derived cysteine proteases in a conditioned medium transfer model
- (2009) Wiebke Wendt et al. JOURNAL OF NEUROCHEMISTRY
- Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75
- (2009) Melanie Mediavilla-Varela et al. Molecular Cancer
- Bid: a Bax-like BH3 protein
- (2009) L P Billen et al. ONCOGENE
- Frequent loss of cystatin E/M expression implicated in the progression of prostate cancer
- (2009) S M Pulukuri et al. ONCOGENE
- Cystatin C Is Downregulated in Prostate Cancer and Modulates Invasion of Prostate Cancer Cells via MAPK/Erk and Androgen Receptor Pathways
- (2009) Barbara Wegiel et al. PLoS One
- Cathepsin L inhibition suppresses drug resistance in vitro and in vivo: a putative mechanism
- (2008) Xin Zheng et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Sortilin mediates the lysosomal targeting of cathepsins D and H
- (2008) Maryssa Canuel et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cathepsins: Key modulators of cell death and inflammatory responses
- (2008) Sébastien Conus et al. BIOCHEMICAL PHARMACOLOGY
- Lysosomal involvement in cell death and cancer
- (2008) Thomas Kirkegaard et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Sorting of lysosomal proteins
- (2008) Thomas Braulke et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Cystatins: Biochemical and structural properties, and medical relevance
- (2008) ">Vito Turk Frontiers in Bioscience-Landmark
- Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues
- (2008) Gabriela Droga-Mazovec et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cysteine cathepsins: Cellular roadmap to different functions
- (2007) Klaudia Brix et al. BIOCHIMIE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started