Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients

High-glucose induces retinal pigment epithelium mitochondrial pathways of apoptosis and inhibits mitophagy by regulating ROS/PINK1/Parkin signal pathway

(2019) Yuanping Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Molecular and cellular regulation of human glucokinase

(2019) Shawn M. Sternisha et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

High glucose-induced phospholipase D activity in retinal pigment epithelium cells: New insights into the molecular mechanisms of diabetic retinopathy

(2019) Paula E. Tenconi et al.   EXPERIMENTAL EYE RESEARCH

Mechanistical retinal drug targets and challenges

(2018) Kai Kaarniranta et al.   ADVANCED DRUG DELIVERY REVIEWS

hiPSC-derived hepatocytes closely mimic the lipid profile of primary hepatocytes: A future personalised cell model for studying the lipid metabolism of the liver

(2018) Mostafa Kiamehr et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

(2018) Szabolcs Felszeghy et al.   Redox Biology

Endogenous insulin signaling in the RPE contributes to the maintenance of rod photoreceptor function in diabetes

(2018) Matthew J. Tarchick et al.   EXPERIMENTAL EYE RESEARCH

Contacting co-culture of human retinal microvascular endothelial cells alters barrier function of human embryonic stem cell derived retinal pigment epithelial cells

(2017) H. Skottman et al.   EXPERIMENTAL CELL RESEARCH

Caffeine Prevents Blood Retinal Barrier Damage in a Model, In Vitro, of Diabetic Macular Edema

(2017) Grazia Maugeri et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nicotine promotes blood retinal barrier damage in a model of human diabetic macular edema

(2017) Grazia Maugeri et al.   TOXICOLOGY IN VITRO

Effects of diabetic retinopathy on the barrier functions of the retinal pigment epithelium

(2017) Tina Xia et al.   VISION RESEARCH

High glucose promotes the migration of retinal pigment epithelial cells through increased oxidative stress and PEDF expression

(2016) Mitra Farnoodian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Autophagy in Diabetic Retinopathy

(2016) Michelino Di Rosa et al.   Current Neuropharmacology

VIP Family Members Prevent Outer Blood Retinal Barrier Damage in a Model of Diabetic Macular Edema

(2016) Grazia Maugeri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The progress in understanding and treatment of diabetic retinopathy

(2016) Alan W. Stitt et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

(2015) Ida Johansson et al.   Autophagy

Inhibition of autophagy induces IL-1β release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress

(2015) Huanqi Shi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparison of Cardiomyocyte Differentiation Potential between Type 1 Diabetic Donor- and Nondiabetic Donor-Derived Induced Pluripotent Stem Cells

(2015) Chika Kikuchi et al.   CELL TRANSPLANTATION

A Comparative View on Easy to Deploy non-Integrating Methods for Patient-Specific iPSC Production

(2015) Stefano Manzini et al.   Stem Cell Reviews and Reports

Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview

(2015) Andrea Matteucci et al.   Biomed Research International

The PI3K/Akt Signaling Pathway Mediates the High Glucose-Induced Expression of Extracellular Matrix Molecules in Human Retinal Pigment Epithelial Cells

(2015) Dong Qin et al.   Journal of Diabetes Research

A Comparative View on Easy to Deploy non-Integrating Methods for Patient-Specific iPSC Production

(2015) Stefano Manzini et al.   Stem Cell Reviews and Reports

Caspase-14 Expression Impairs Retinal Pigment Epithelium Barrier Function: Potential Role in Diabetic Macular Edema

(2014) Selina Beasley et al.   Biomed Research International

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells

(2013) Johanna Viiri et al.   PLoS One

Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions

(2013) Ingeborg Klaassen et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Using human induced pluripotent stem cells to treat retinal disease

(2013) S. Borooah et al.   PROGRESS IN RETINAL AND EYE RESEARCH

High Glucose Induced Differential Expression of Lysyl Oxidase and Its Isoform in ARPE-19 Cells

(2012) Karunakaran Coral et al.   CURRENT EYE RESEARCH

Effect of high glucose on secreted proteome in cultured retinal pigmented epithelium cells: Its possible relevance to clinical diabetic retinopathy

(2012) You-Hsuan Chen et al.   Journal of Proteomics

High-throughput karyotyping of human pluripotent stem cells

(2012) Riikka J. Lund et al.   Stem Cell Research

Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics)

(2011) Tomoaki Uchiki et al.   AGING CELL

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of high glucose concentration on the barrier function and the expression of tight junction proteins in human retinal pigment epithelial cells

(2009) Marta Villarroel et al.   EXPERIMENTAL EYE RESEARCH