Molecular Mechanisms of Cancer-Induced Sleep Disruption

Glucocorticoids promote breast cancer metastasis

(2019) Milan M. S. Obradović et al.   NATURE

Sleep modulates haematopoiesis and protects against atherosclerosis

(2019) Cameron S. McAlpine et al.   NATURE

Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities

(2019) Xiaoyu Liu et al.   IMMUNITY

Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes

(2019) Nazanin Rohani et al.   CANCER RESEARCH

GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice

(2019) Srikanta Chowdhury et al.   eLife

A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer

(2018) Jeremy C. Borniger et al.   Cell Metabolism

Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states

(2018) William J. Giardino et al.   NATURE NEUROSCIENCE

Modulation of anti-tumor immunity by the brain’s reward system

(2018) Tamar L Ben-Shaanan et al.   Nature Communications

Role of TNF–TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications

(2018) Sujuan Yang et al.   Frontiers in Immunology

T cells in patients with narcolepsy target self-antigens of hypocretin neurons

(2018) Daniela Latorre et al.   NATURE

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment

(2018) Erin M. Gibson et al.   CELL

GABA and glutamate neurons in the VTA regulate sleep and wakefulness

(2018) Xiao Yu et al.   NATURE NEUROSCIENCE

Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy

(2018) Guo Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness

(2018) Hiroshi Yamaguchi et al.   Nature Communications

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus

(2017) Carlos A Campos et al.   NATURE NEUROSCIENCE

Neural Circuitry of Wakefulness and Sleep

(2017) Thomas E. Scammell et al.   NEURON

A Genetically Defined Circuit for Arousal from Sleep during Hypercapnia

(2017) Satvinder Kaur et al.   NEURON

Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli

(2017) Jounhong Ryan Cho et al.   NEURON

Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive

(2017) Ada Eban-Rothschild et al.   NEUROPSYCHOPHARMACOLOGY

Role of tumor microenvironment in tumorigenesis

(2017) Maonan Wang et al.   Journal of Cancer

Ghrelin and Breast Cancer: Emerging Roles in Obesity, Estrogen Regulation, and Cancer

(2017) CheukMan Cherie Au et al.   Frontiers in Oncology

Time-of-Day Dictates Transcriptional Inflammatory Responses to Cytotoxic Chemotherapy

(2017) Jeremy C. Borniger et al.   Scientific Reports

Mindfulness meditation and the immune system: a systematic review of randomized controlled trials

(2016) David S. Black et al.   Annals of the New York Academy of Sciences

Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis

(2016) Selma Masri et al.   CELL

Parabrachial CGRP Neurons Control Meal Termination

(2016) Carlos A. Campos et al.   Cell Metabolism

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

(2016) Thales Papagiannakopoulos et al.   Cell Metabolism

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

(2016) Baokun He et al.   Cell Metabolism

Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity

(2016) Thomas R. Flint et al.   Cell Metabolism

Sleep and cancer: Synthesis of experimental data and meta-analyses of cancer incidence among some 1,500,000 study individuals in 13 countries

(2016) T.C. Erren et al.   CHRONOBIOLOGY INTERNATIONAL

Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour

(2016) Patricia Bonnavion et al.   JOURNAL OF PHYSIOLOGY-LONDON

Is chronic fatigue syndrome an inflammatory disorder?

(2016) R. Strawbridge et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

The two-process model of sleep regulation: a reappraisal

(2016) Alexander A. Borbély et al.   JOURNAL OF SLEEP RESEARCH

Activation of the reward system boosts innate and adaptive immunity

(2016) Tamar L Ben-Shaanan et al.   NATURE MEDICINE

VTA dopaminergic neurons regulate ethologically relevant sleep–wake behaviors

(2016) Ada Eban-Rothschild et al.   NATURE NEUROSCIENCE

Sleep function: Toward elucidating an enigma

(2016) James M. Krueger et al.   SLEEP MEDICINE REVIEWS

Circadian disruption and biomarkers of tumor progression in breast cancer patients awaiting surgery

(2015) E. Cash et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of an interleukin-1 receptor antagonist on human sleep, sleep-associated memory consolidation, and blood monocytes

(2015) Eva-Maria Schmidt et al.   BRAIN BEHAVIOR AND IMMUNITY

The paradoxical role of IL-10 in immunity and cancer

(2015) Mark H. Mannino et al.   CANCER LETTERS

Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice

(2015) Kirsten C.G. Van Dycke et al.   CURRENT BIOLOGY

The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathway

(2015) JIANCHU CHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Optogenetic Evidence for Inhibitory Signaling from Orexin to MCH Neurons via Local Microcircuits

(2015) J. Apergis-Schoute et al.   JOURNAL OF NEUROSCIENCE

Glucose Induces Slow-Wave Sleep by Exciting the Sleep-Promoting Neurons in the Ventrolateral Preoptic Nucleus: A New Link between Sleep and Metabolism

(2015) C. Varin et al.   JOURNAL OF NEUROSCIENCE

Targeting the TGFβ pathway for cancer therapy

(2015) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

Insomnia Caused by Serotonin Depletion is Due to Hypothermia

(2015) Nicholas M. Murray et al.   SLEEP

Versatile functions for IL-6 in metabolism and cancer

(2015) Jan Mauer et al.   TRENDS IN IMMUNOLOGY

Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses

(2015) Patricia Bonnavion et al.   Nature Communications

Insomnia Caused by Serotonin Depletion is Due to Hypothermia

(2015) Nicholas M. Murray et al.   SLEEP

A day and night difference in the response of the hepatic transcriptome to cyclophosphamide treatment

(2014) Kirsten C. G. Van Dycke et al.   ARCHIVES OF TOXICOLOGY

Impact of breast cancer treatments on sleep disturbances – A systematic review

(2014) Ana Rute Costa et al.   BREAST

Mindfulness meditation for younger breast cancer survivors: A randomized controlled trial

(2014) Julienne E. Bower et al.   CANCER

Fragmented Sleep Accelerates Tumor Growth and Progression through Recruitment of Tumor-Associated Macrophages and TLR4 Signaling

(2014) F. Hakim et al.   CANCER RESEARCH

Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer

(2014) R. T. Dauchy et al.   CANCER RESEARCH

Loss of circadian clock gene expression is associated with tumor progression in breast cancer

(2014) Cristina Cadenas et al.   CELL CYCLE

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Dorsal Raphe Neurons Signal Reward through 5-HT and Glutamate

(2014) Zhixiang Liu et al.   NEURON

Psychological and physical distress are interdependent in breast cancer survivors and their partners

(2014) Chris Segrin et al.   Psychology Health & Medicine

Actigraphy-Measured Sleep Disruption as a Predictor of Survival among Women with Advanced Breast Cancer

(2014) Oxana Palesh et al.   SLEEP

Hyperglycemia as a Risk Factor for Cancer Progression

(2014) Tae Young Ryu et al.   Diabetes & Metabolism Journal

Long-lasting silencing of orexin/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice

(2013) Tomomi Tsunematsu et al.   BEHAVIOURAL BRAIN RESEARCH

Tumor-dependent increase of serum amino acid levels in breast cancer patients has diagnostic potential and correlates with molecular tumor subtypes

(2013) Isabel Poschke et al.   Journal of Translational Medicine

MCT2 Expression and Lactate Influx in Anorexigenic and Orexigenic Neurons of the Arcuate Nucleus

(2013) Christian Cortes-Campos et al.   PLoS One

Melanin-concentrating hormone control of sleep–wake behavior

(2013) Jaime M. Monti et al.   SLEEP MEDICINE REVIEWS

Leptin: A biomarker for sleep disorders?

(2013) Weihong Pan et al.   SLEEP MEDICINE REVIEWS

Analysis of sleep disorders under pain using an optogenetic tool: possible involvement of the activation of dorsal raphe nucleus-serotonergic neurons

(2013) Hisakatsu Ito et al.   Molecular Brain

Association between Obstructive Sleep Apnea and Cancer Incidence in a Large Multicenter Spanish Cohort

(2012) Francisco Campos-Rodriguez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Fatigue and sleep quality are associated with changes in inflammatory markers in breast cancer patients undergoing chemotherapy

(2012) Lianqi Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation and cancer-related fatigue: Mechanisms, contributing factors, and treatment implications

(2012) Julienne E. Bower et al.   BRAIN BEHAVIOR AND IMMUNITY

Diurnal cortisol rhythm as a predictor of lung cancer survival

(2012) Sandra E. Sephton et al.   BRAIN BEHAVIOR AND IMMUNITY

MECHANISMS IN ENDOCRINOLOGY: Ghrelin: the differences between acyl- and des-acyl ghrelin

(2012) Patric J D Delhanty et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6

(2012) Stefan Rose-John   International Journal of Biological Sciences

IL-4 in the Brain: A Cytokine To Remember

(2012) Sachin P. Gadani et al.   JOURNAL OF IMMUNOLOGY

Translational approaches to treatment-induced symptoms in cancer patients

(2012) Robert Dantzer et al.   Nature Reviews Clinical Oncology

Mechanism for Hypocretin-mediated sleep-to-wake transitions

(2012) M. E. Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of ghrelin is correlated to a favorable outcome in invasive breast cancer

(2011) Malin Grönberg et al.   ACTA ONCOLOGICA

IL-6 Controls Leukemic Multipotent Progenitor Cell Fate and Contributes to Chronic Myelogenous Leukemia Development

(2011) Damien Reynaud et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Alternative activation of tumor-associated macrophages by IL-4

(2011) Hao-Wei Wang et al.   CELL CYCLE

Cytokine Signaling Modulates Blood-Brain Barrier Function

(2011) Weihong Pan et al.   CURRENT PHARMACEUTICAL DESIGN

Inflammation and Behavioral Symptoms After Breast Cancer Treatment: Do Fatigue, Depression, and Sleep Disturbance Share a Common Underlying Mechanism?

(2011) Julienne E. Bower et al.   JOURNAL OF CLINICAL ONCOLOGY

Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids

(2011) Mahesh M. Karnani et al.   NEURON

Optogenetic investigation of neural circuits in vivo

(2011) Matthew E. Carter et al.   TRENDS IN MOLECULAR MEDICINE

Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal

(2011) Takeshi Sakurai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Clinical Investigation of the Role of Interleukin-4 and Interleukin-13 in the Evolution of Prostate Cancer

(2011) Robert Goldstein et al.   Cancers

Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination

(2010) Shuqin Zhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivo

(2010) Gang Luo et al.   CANCER BIOLOGY & THERAPY

Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells

(2010) Yue Wang et al.   CANCER LETTERS

DNA Damage-Mediated Induction of a Chemoresistant Niche

(2010) Luke A. Gilbert et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Glucose Stimulation of Hypothalamic MCH Neurons Involves KATP Channels, Is Modulated by UCP2, and Regulates Peripheral Glucose Homeostasis

(2010) Dong Kong et al.   Cell Metabolism

Tuning arousal with optogenetic modulation of locus coeruleus neurons

(2010) Matthew E Carter et al.   NATURE NEUROSCIENCE

Sleep State Switching

(2010) Clifford B. Saper et al.   NEURON

Characteristics of compounds that cross the blood-brain barrier

(2009) William A Banks   BMC Neurology

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

A Major Role for Perifornical Orexin Neurons in the Control of Glucose Metabolism in Rats

(2009) C.-X. Yi et al.   DIABETES

Serum interleukin-6 levels in colorectal cancer patients—a summary of published results

(2009) Heike Knüpfer et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Prevalence, Demographics, and Psychological Associations of Sleep Disruption in Patients With Cancer: University of Rochester Cancer Center–Community Clinical Oncology Program

(2009) Oxana G. Palesh et al.   JOURNAL OF CLINICAL ONCOLOGY

The slow (

(2009) Vincenzo Crunelli et al.   NATURE NEUROSCIENCE

How (and why) the immune system makes us sleep

(2009) Luca Imeri et al.   NATURE REVIEWS NEUROSCIENCE

Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle

(2009) O. K. Hassani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The Neurobiology of Sleep

(2009) Jerome Siegel   SEMINARS IN NEUROLOGY

Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic mice

(2008) A. D. Laposky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH

Functional Neuroanatomy of the Noradrenergic Locus Coeruleus: Its Roles in the Regulation of Arousal and Autonomic Function Part I: Principles of Functional Organisation

(2008) E. Samuels et al.   Current Neuropharmacology

Cachexia Worsens Prognosis in Patients with Resectable Pancreatic Cancer

(2008) Jeannine Bachmann et al.   JOURNAL OF GASTROINTESTINAL SURGERY

A single night of sleep deprivation increases ghrelin levels and feelings of hunger in normal-weight healthy men

(2008) SEBASTIAN M. SCHMID et al.   JOURNAL OF SLEEP RESEARCH

Immune-To-Brain Signaling: How Important are the Blood–Brain Barrier-independent Pathways?

(2008) Ning Quan   MOLECULAR NEUROBIOLOGY

Abnormal response of melanin-concentrating hormone deficient mice to fasting: Hyperactivity and rapid eye movement sleep suppression

(2008) J.T. Willie et al.   NEUROSCIENCE

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE