Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour

An Emerging Technology Framework for the Neurobiology of Appetite

(2016) Scott M. Sternson et al.   Cell Metabolism

Feeding and Reward Are Differentially Induced by Activating GABAergic Lateral Hypothalamic Projections to VTA

(2016) M. F. Barbano et al.   JOURNAL OF NEUROSCIENCE

Orexin Neurons Respond Differentially to Auditory Cues Associated with Appetitive versus Aversive Outcomes

(2016) Oum Kaltoum Hassani et al.   JOURNAL OF NEUROSCIENCE

QRFP and Its Receptors Regulate Locomotor Activity and Sleep in Zebrafish

(2016) A. Chen et al.   JOURNAL OF NEUROSCIENCE

Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward

(2016) A. M. Stamatakis et al.   JOURNAL OF NEUROSCIENCE

Lateral hypothalamic circuits for feeding and reward

(2016) Garret D Stuber et al.   NATURE NEUROSCIENCE

Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks

(2016) J. Antonio González et al.   Nature Communications

Neural Control of Energy Balance: Translating Circuits to Therapies

(2015) Laurent Gautron et al.   CELL

Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping

(2015) Kevin T. Beier et al.   CELL

Decoding Neural Circuits that Control Compulsive Sucrose Seeking

(2015) Edward H. Nieh et al.   CELL

Visualizing Hypothalamic Network Dynamics for Appetitive and Consummatory Behaviors

(2015) Joshua H. Jennings et al.   CELL

Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake

(2015) Zhiying Li et al.   Cell Metabolism

Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9

(2015) J. Liu et al.   DEVELOPMENT

Ventral Tegmental Area Neurotensin Signaling Links the Lateral Hypothalamus to Locomotor Activity and Striatal Dopamine Efflux in Male Mice

(2015) Christa M. Patterson et al.   ENDOCRINOLOGY

Optogenetic Evidence for Inhibitory Signaling from Orexin to MCH Neurons via Local Microcircuits

(2015) J. Apergis-Schoute et al.   JOURNAL OF NEUROSCIENCE

Optogenetic Stimulation of Accumbens Shell or Shell Projections to Lateral Hypothalamus Produce Differential Effects on the Motivation for Cocaine

(2015) E. B. Larson et al.   JOURNAL OF NEUROSCIENCE

Melanin-Concentrating Hormone Neurons Release Glutamate for Feedforward Inhibition of the Lateral Septum

(2015) M. J. S. Chee et al.   JOURNAL OF NEUROSCIENCE

GABAergic Projections from Lateral Hypothalamus to Paraventricular Hypothalamic Nucleus Promote Feeding

(2015) Z. Wu et al.   JOURNAL OF NEUROSCIENCE

Hypothalamic feedforward inhibition of thalamocortical network controls arousal and consciousness

(2015) Carolina Gutierrez Herrera et al.   NATURE NEUROSCIENCE

Interactions of the histamine and hypocretin systems in CNS disorders

(2015) Ling Shan et al.   Nature Reviews Neurology

Accumbal D1R Neurons Projecting to Lateral Hypothalamus Authorize Feeding

(2015) Eoin C. O’Connor et al.   NEURON

Neurotransmitter Switching? No Surprise

(2015) Nicholas C. Spitzer   NEURON

Specification of Select Hypothalamic Circuits and Innate Behaviors by the Embryonic Patterning Gene Dbx1

(2015) Katie Sokolowski et al.   NEURON

Orexins and fear: implications for the treatment of anxiety disorders

(2015) África Flores et al.   TRENDS IN NEUROSCIENCES

Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses

(2015) Patricia Bonnavion et al.   Nature Communications

Hypocretin neuron-specific transcriptome profiling identifies the sleep modulator Kcnh4a

(2015) Laura Yelin-Bekerman et al.   eLife

Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons

(2015) Amanda Laque et al.   Molecular Metabolism

Hypocretin (orexin) neuromodulation of stress and reward pathways

(2014) William J Giardino et al.   CURRENT OPINION IN NEUROBIOLOGY

Optogenetic Manipulation of Activity and Temporally Controlled Cell-Specific Ablation Reveal a Role for MCH Neurons in Sleep/Wake Regulation

(2014) T. Tsunematsu et al.   JOURNAL OF NEUROSCIENCE

Leptin Acts via Lateral Hypothalamic Area Neurotensin Neurons to Inhibit Orexin Neurons by Multiple GABA-Independent Mechanisms

(2014) P. B. Goforth et al.   JOURNAL OF NEUROSCIENCE

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

(2014) Michael J. Krashes et al.   NATURE

The role of orexin in motivated behaviours

(2014) Takeshi Sakurai   NATURE REVIEWS NEUROSCIENCE

Lateral hypothalamic thyrotropin-releasing hormone neurons: Distribution and relationship to histochemically defined cell populations in the rat

(2014) E. Horjales-Araujo et al.   NEUROSCIENCE

Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area

(2014) J. W. Muschamp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coreleased Orexin and Glutamate Evoke Nonredundant Spike Outputs and Computations in Histamine Neurons

(2014) Cornelia Schöne et al.   Cell Reports

Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar

(2014) Ana I Domingos et al.   eLife

Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action

(2013) Amanda Laque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Control of arousal by the orexin neurons

(2013) Chloe Alexandre et al.   CURRENT OPINION IN NEUROBIOLOGY

Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation

(2013) J. Dalal et al.   GENES & DEVELOPMENT

Lateral Hypothalamus Contains Two Types of Palatability-Related Taste Responses with Distinct Dynamics

(2013) J. X. Li et al.   JOURNAL OF NEUROSCIENCE

Hypothalamic Neurotensin Projections Promote Reward by Enhancing Glutamate Transmission in the VTA

(2013) K. A. Kempadoo et al.   JOURNAL OF NEUROSCIENCE

Optogenetic Stimulation of MCH Neurons Increases Sleep

(2013) R. R. Konadhode et al.   JOURNAL OF NEUROSCIENCE

Orexin Receptor-1 in the Locus Coeruleus Plays an Important Role in Cue-Dependent Fear Memory Consolidation

(2013) S. Soya et al.   JOURNAL OF NEUROSCIENCE

Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus

(2013) Sonia Jego et al.   NATURE NEUROSCIENCE

Hypothalamic Survival Circuits: Blueprints for Purposive Behaviors

(2013) Scott M. Sternson   NEURON

Lateral hypothalamus as a sensor-regulator in respiratory and metabolic control

(2013) Denis Burdakov et al.   PHYSIOLOGY & BEHAVIOR

Neurotensin Co-Expressed in Orexin-Producing Neurons in the Lateral Hypothalamus Plays an Important Role in Regulation of Sleep/Wakefulness States

(2013) Naoki Furutani et al.   PLoS One

Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus

(2013) R. M. Sears et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inhibitory Circuit Architecture of the Lateral Hypothalamus Orchestrates Feeding

(2013) J. H. Jennings et al.   SCIENCE

The Role of Hcrt/Orx and MCH Neurons in Sleep-Wake State Regulation

(2013) Barbara E. Jones et al.   SLEEP

GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons

(2013) Yuki C. Saito et al.   Frontiers in Neural Circuits

The Role of Melanin-Concentrating Hormone and Its Receptors in Energy Homeostasis

(2013) Douglas J. MacNeil   Frontiers in Endocrinology

Convergent inputs from electrically and topographically distinct orexin cells to locus coeruleus and ventral tegmental area

(2012) J. Antonio González et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area

(2012) Huxing Cui et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Narcolepsy: Neural Mechanisms of Sleepiness and Cataplexy

(2012) C. R. Burgess et al.   JOURNAL OF NEUROSCIENCE

The Lateral Hypothalamic Area Controls Paradoxical (REM) Sleep by Means of Descending Projections to Brainstem GABAergic Neurons

(2012) O. Clement et al.   JOURNAL OF NEUROSCIENCE

Optogenetic Probing of Fast Glutamatergic Transmission from Hypocretin/Orexin to Histamine Neurons In Situ

(2012) C. Schone et al.   JOURNAL OF NEUROSCIENCE

Lateral hypothalamic GAD65 neurons are spontaneously firing and distinct from orexin- and melanin-concentrating hormone neurons

(2012) Mahesh M. Karnani et al.   JOURNAL OF PHYSIOLOGY-LONDON

Immunohistochemical evidence for synaptic release of GABA from melanin-concentrating hormone containing varicosities in the locus coeruleus

(2012) E. del Cid-Pellitero et al.   NEUROSCIENCE

Mechanism for Hypocretin-mediated sleep-to-wake transitions

(2012) M. E. Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamate and GABA as rapid effectors of hypothalamic “peptidergic” neurons

(2012) Cornelia Schöne et al.   Frontiers in Behavioral Neuroscience

Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells

(2011) Christa M. Patterson et al.   BRAIN RESEARCH

Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance

(2011) Gina M. Leinninger et al.   Cell Metabolism

The lateral hypothalamic parvalbumin-immunoreactive (PV1) nucleus in rodents

(2011) Zoltán Mészár et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Dichotomous cellular properties of mouse orexin/hypocretin neurons

(2011) Cornelia Schöne et al.   JOURNAL OF PHYSIOLOGY-LONDON

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

(2011) Linh Vong et al.   NEURON

Lateral thinking about leptin: A review of leptin action via the lateral hypothalamus

(2011) Gina M. Leinninger   PHYSIOLOGY & BEHAVIOR

The lateral hypothalamus as integrator of metabolic and environmental needs: From electrical self-stimulation to opto-genetics

(2011) Hans-Rudi Berthoud et al.   PHYSIOLOGY & BEHAVIOR

Optogenetic disruption of sleep continuity impairs memory consolidation

(2011) Asya Rolls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal

(2011) Takeshi Sakurai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Orexin Signaling Via the Orexin 1 Receptor Mediates Operant Responding for Food Reinforcement

(2010) Ruth Sharf et al.   BIOLOGICAL PSYCHIATRY

Distinct patterns of neuronal inputs and outputs of the juxtaparaventricular and suprafornical regions of the lateral hypothalamic area in the male rat

(2010) Joel D. Hahn et al.   BRAIN RESEARCH REVIEWS

Hypocretins in the Control of Sleep and Wakefulness

(2010) Patricia Bonnavion et al.   Current Neurology and Neuroscience Reports

GABAergic neurons intermingled with orexin and MCH neurons in the lateral hypothalamus discharge maximally during sleep

(2010) Oum Kaltoum Hassani et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Direct Innervation and Modulation of Orexin Neurons by Lateral Hypothalamic LepRb Neurons

(2010) G. W. Louis et al.   JOURNAL OF NEUROSCIENCE

A genomic atlas of mouse hypothalamic development

(2010) Tomomi Shimogori et al.   NATURE NEUROSCIENCE

Sleep State Switching

(2010) Clifford B. Saper et al.   NEURON

Direct inhibition of hypocretin/orexin neurons in the lateral hypothalamus by nociceptin/orphanin FQ blocks stress-induced analgesia in rats

(2010) Dmitry Gerashchenko et al.   NEUROPHARMACOLOGY

Immunohistochemical evidence for synaptic release of glutamate from orexin terminals in the locus coeruleus

(2010) P. Henny et al.   NEUROSCIENCE

A Very Large Number of GABAergic Neurons Are Activated in the Tuberal Hypothalamus during Paradoxical (REM) Sleep Hypersomnia

(2010) Emilie Sapin et al.   PLoS One

Hypocretin/orexin in arousal and stress

(2009) Craig W. Berridge et al.   BRAIN RESEARCH

The Geometry of Leptin Action in the Brain: More Complicated Than a Simple ARC

(2009) Martin G. Myers et al.   Cell Metabolism

Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding

(2009) Gina M. Leinninger et al.   Cell Metabolism

Hypocretin /orexin contributes to the expression of some but not all forms of stress and arousal

(2009) Teri M. Furlong et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Leptin targets in the mouse brain

(2009) Michael M. Scott et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Nociceptin/Orphanin FQ Peptide in Hypothalamic Neurones Associated with the Control of Feeding Behaviour

(2009) N. Maolood et al.   JOURNAL OF NEUROENDOCRINOLOGY

Sleep Homeostasis Modulates Hypocretin-Mediated Sleep-to-Wake Transitions

(2009) M. E. Carter et al.   JOURNAL OF NEUROSCIENCE

Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

(2009) S. L. Borgland et al.   JOURNAL OF NEUROSCIENCE

A key role for orexin in panic anxiety

(2009) Philip L Johnson et al.   NATURE MEDICINE

Comparison of melanin-concentrating hormone and hypocretin/orexin peptide expression patterns in a current parceling scheme of the lateral hypothalamic zone

(2009) Joel D. Hahn   NEUROSCIENCE LETTERS

Selective loss of GABAB receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture

(2009) T. Matsuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle

(2009) O. K. Hassani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The melanin-concentrating hormone system modulates cocaine reward

(2009) S. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of the Mesolimbic Dopamine System and Reward in MCH−/− Mice

(2008) Pavlos Pissios et al.   BIOLOGICAL PSYCHIATRY

Cholinergic Regulation of Orexin/Hypocretin Neurons Through M3 Muscarinic Receptor in Mice

(2008) Kousaku Ohno et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS

(2008) K.S. Foo et al.   NEUROSCIENCE

The satiety molecule nesfatin-1 is co-expressed with melanin concentrating hormone in tuberal hypothalamic neurons of the rat

(2008) P. Fort et al.   NEUROSCIENCE

Neuronal activity of orexin and non-orexin waking-active neurons during wake–sleep states in the mouse

(2008) K. Takahashi et al.   NEUROSCIENCE

Melanin-concentrating hormone projections to areas involved in somatomotor responses

(2007) C.F. Elias et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Addiction and arousal: The hypocretin connection

(2007) Benjamin Boutrel et al.   PHYSIOLOGY & BEHAVIOR