Retrograde labeling, transduction, and genetic targeting allow cellular analysis of corticospinal motor neurons: implications in health and disease

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease

(2014) Sian E. Davies et al.   NEUROBIOLOGY OF DISEASE

Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders

(2014) G. Novarino et al.   SCIENCE

Genetic Approaches to Neural Circuits in the Mouse

(2013) Z. Josh Huang et al.   Annual Review of Neuroscience

A Nanobody-Based System Using Fluorescent Proteins as Scaffolds for Cell-Specific Gene Manipulation

(2013) Jonathan C.Y. Tang et al.   CELL

Moving forward in clinical trials for ALS: motor neurons lead the way please

(2013) Barış Genç et al.   DRUG DISCOVERY TODAY

Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2delivery to motor neurons

(2013) Takenari Yamashita et al.   EMBO Molecular Medicine

Imaging cell biology in live animals: Ready for prime time

(2013) Roberto Weigert et al.   JOURNAL OF CELL BIOLOGY

eGFP Expression under UCHL1 Promoter Genetically Labels Corticospinal Motor Neurons and a Subpopulation of Degeneration-Resistant Spinal Motor Neurons in an ALS Mouse Model

(2013) M. V. Yasvoina et al.   JOURNAL OF NEUROSCIENCE

Improved tools for the Brainbow toolbox

(2013) Dawen Cai et al.   NATURE METHODS

Targeting neurons and photons for optogenetics

(2013) Adam M Packer et al.   NATURE NEUROSCIENCE

Corticostriatal connectivity and its role in disease

(2013) Gordon M. G. Shepherd   NATURE REVIEWS NEUROSCIENCE

GENSAT BAC Cre-Recombinase Driver Lines to Study the Functional Organization of Cerebral Cortical and Basal Ganglia Circuits

(2013) Charles R. Gerfen et al.   NEURON

Gene and protein therapies utilizing VEGF for ALS

(2013) Orion P. Keifer et al.   PHARMACOLOGY & THERAPEUTICS

Selective Vulnerability of Spinal and Cortical Motor Neuron Subpopulations in delta7 SMA Mice

(2013) Paolo d’Errico et al.   PLoS One

Tools, methods, and applications for optophysiology in neuroscience

(2013) Niklas Smedemark-Margulies et al.   Frontiers in Molecular Neuroscience

Fluorescent proteins for FRET microscopy: Monitoring protein interactions in living cells

(2012) Richard N. Day et al.   BIOESSAYS

Modern fluorescent proteins: from chromophore formation to novel intracellular applications

(2012) Olesya Stepanenko et al.   BIOTECHNIQUES

Intrinsic Electrophysiology of Mouse Corticospinal Neurons: a Class-Specific Triad of Spike-Related Properties

(2012) B. A. Suter et al.   CEREBRAL CORTEX

Unveiling the diversity of thalamocortical neuron subtypes

(2012) Francisco Clascá et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

In vivo imaging

(2012) Claudia J. Laskowski et al.   EXPERIMENTAL NEUROLOGY

Hierarchical Connectivity and Connection-Specific Dynamics in the Corticospinal-Corticostriatal Microcircuit in Mouse Motor Cortex

(2012) T. Kiritani et al.   JOURNAL OF NEUROSCIENCE

Laminarly Orthogonal Excitation of Fast-Spiking and Low-Threshold-Spiking Interneurons in Mouse Motor Cortex

(2012) A. J. Apicella et al.   JOURNAL OF NEUROSCIENCE

Optogenetic stimulation of a hippocampal engram activates fear memory recall

(2012) Xu Liu et al.   NATURE

AAV2 mediated retrograde transduction of corticospinal motor neurons reveals initial and selective apical dendrite degeneration in ALS

(2012) Javier H. Jara et al.   NEUROBIOLOGY OF DISEASE

Adeno-associated virus (AAV) gene therapy for neurological disease

(2012) Marc S. Weinberg et al.   NEUROPHARMACOLOGY

Multiplexed visualization of dynamic signaling networks using genetically encoded fluorescent protein-based biosensors

(2012) Charlene Depry et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Genetic Labeling of Neuronal Subsets through Enhancer Trapping in Mice

(2012) Wolfgang Kelsch et al.   PLoS One

Efficient Differentiation of Mouse Embryonic Stem Cells into Motor Neurons

(2012) Chia-Yen Wu et al.   Jove-Journal of Visualized Experiments

Intravital Imaging

(2011) Mikael J. Pittet et al.   CELL

Corticospinal tract transduction: a comparison of seven adeno-associated viral vector serotypes and a non-integrating lentiviral vector

(2011) T H Hutson et al.   GENE THERAPY

Comparison of Adeno-Associated Viral Vector Serotypes for Spinal Cord and Motor Neuron Gene Delivery

(2011) Brooke R. Snyder et al.   HUMAN GENE THERAPY

A half century of experimental neuroanatomical tracing

(2011) José L. Lanciego et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Corticospinal-specific HCN expression in mouse motor cortex: Ih-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control

(2011) Patrick L. Sheets et al.   JOURNAL OF NEUROPHYSIOLOGY

Corticospinal Motor Neurons and Related Subcerebral Projection Neurons Undergo Early and Specific Neurodegeneration in hSOD1G93A Transgenic ALS Mice

(2011) P. H. Ozdinler et al.   JOURNAL OF NEUROSCIENCE

Glycine Receptor Channels in Spinal Motoneurons Are Abnormal in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

(2011) Q. Chang et al.   JOURNAL OF NEUROSCIENCE

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons

(2011) M. Decressac et al.   NEUROBIOLOGY OF DISEASE

A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex

(2011) Hiroki Taniguchi et al.   NEURON

Local Connections of Layer 5 GABAergic Interneurons to Corticospinal Neurons

(2011) Yasuyo H. Tanaka et al.   Frontiers in Neural Circuits

The Microcircuit Concept Applied to Cortical Evolution: from Three-Layer to Six-Layer Cortex

(2011) Gordon M. Shepherd   Frontiers in Neuroanatomy

Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation

(2011) Taruna Ikrar et al.   Jove-Journal of Visualized Experiments

Projections from the brain to the spinal cord in the mouse

(2010) Huazheng Liang et al.   Brain Structure & Function

GDNF Acts as a Chemoattractant to Support ephrinA-Induced Repulsion of Limb Motor Axons

(2010) Irina Dudanova et al.   CURRENT BIOLOGY

Lack of humoral immune response to the tetracycline (Tet) activator in rats injected intracranially with Tet-off rAAV vectors

(2010) Y Han et al.   GENE THERAPY

AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway

(2010) Karine Langou et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotection by Gene Therapy Targeting Mutant SOD1 in Individual Pools of Motor Neurons Does not Translate Into Therapeutic Benefit in fALS Mice

(2010) Chris Towne et al.   MOLECULAR THERAPY

CNS-targeted Viral Delivery of G-CSF in an Animal Model for ALS: Improved Efficacy and Preservation of the Neuromuscular Unit

(2010) Alexandre Henriques et al.   MOLECULAR THERAPY

Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex

(2010) Charles T Anderson et al.   NATURE NEUROSCIENCE

Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer's Disease Mice

(2010) Tobias Bittner et al.   PLoS One

AAV as a Gene Transfer Vector for the Treatment of Neurological Disorders: Novel Treatment Thoughts for ALS

(2009) Mark Hester et al.   CURRENT GENE THERAPY

Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS

(2009) S. Karumbayaram et al.   Disease Models & Mechanisms

Axonal Transport Defects in Neurodegenerative Diseases

(2009) G. A. Morfini et al.   JOURNAL OF NEUROSCIENCE

Corticospinal neurons respond differentially to neurotrophins and myelin-associated glycoprotein in vitro

(2009) Miranda W. Richter et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Axonal and neuromuscular synaptic phenotypes in WldS, SOD1G93A and ostes mutant mice identified by fiber-optic confocal microendoscopy

(2009) Frances Wong et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mimicking Aspects of Frontotemporal Lobar Degeneration and Lou Gehrig's Disease in Rats via TDP-43 Overexpression

(2009) Jason B Tatom et al.   MOLECULAR THERAPY

Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival

(2009) Neil A Shneider et al.   Neural Development

Local-circuit phenotypes of layer 5 neurons in motor-frontal cortex of YFP-H mice

(2009) Jianing Yu   Frontiers in Neural Circuits

2008 Nobel Prize in Chemistry: Green Fluorescent Protein, Its Variants and Implications

(2008)   ACS Nano

Descending Pathways in Motor Control

(2008) Roger N. Lemon   Annual Review of Neuroscience

Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types

(2008) Joseph P. Doyle et al.   CELL

Embryonic motor axon development in the severe SMA mouse

(2008) V. L. McGovern et al.   HUMAN MOLECULAR GENETICS

A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping

(2008) D. Atasoy et al.   JOURNAL OF NEUROSCIENCE

A Novel Purification Method for CNS Projection Neurons Leads to the Identification of Brain Vascular Cells as a Source of Trophic Support for Corticospinal Motor Neurons

(2008) J. C. Dugas et al.   JOURNAL OF NEUROSCIENCE

Delivery of AAV-IGF-1 to the CNS Extends Survival in ALS Mice Through Modification of Aberrant Glial Cell Activity

(2008) James C Dodge et al.   MOLECULAR THERAPY

Molecular mechanisms of axon guidance in the developing corticospinal tract

(2008) A.J. Canty et al.   PROGRESS IN NEUROBIOLOGY

BAC Transgenesis in Human Embryonic Stem Cells as a Novel Tool to Define the Human Neural Lineage

(2008) Dimitris G. Placantonakis et al.   STEM CELLS