Hydrogen deuterium exchange mass spectrometry applied to chaperones and chaperone-assisted protein folding

Hydrogen exchange reveals Hsp104 architecture, structural dynamics, and energetics in physiological solution

(2019) Xiang Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story

(2019) Daniel Gestaut et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Hsp70- and Hsp90-Mediated Regulation of the Conformation of p53 DNA Binding Domain and p53 Cancer Variants

(2019) Marta Boysen et al.   MOLECULAR CELL

Protein–Protein Interactions in the Molecular Chaperone Network

(2018) Rebecca Freilich et al.   ACCOUNTS OF CHEMICAL RESEARCH

GroEL Ring Separation and Exchange in the Chaperonin Reaction

(2018) Xiao Yan et al.   CELL

Protein Folding Mediated by Trigger Factor and Hsp70: New Insights from Single-Molecule Approaches

(2018) Florian Wruck et al.   JOURNAL OF MOLECULAR BIOLOGY

Hydrogen-deuterium exchange mass spectrometry reveals folding and allostery in protein-protein interactions

(2018) Cesar A. Ramirez-Sarmiento et al.   METHODS

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1–Npl4

(2018) Nicholas O. Bodnar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Folding of maltose binding protein outside of and in GroEL

(2018) Xiang Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System

(2018) Tom D. Bunney et al.   STRUCTURE

The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading

(2018) Brooke M. Gardner et al.   Nature Communications

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1–Npl4

(2018) Nicholas O. Bodnar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pathway of Actin Folding Directed by the Eukaryotic Chaperonin TRiC

(2018) David Balchin et al.   CELL

Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones

(2018) Matthias P Mayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human stress-inducible Hsp70 has a high propensity to form ATP-dependent antiparallel dimers that are differentially regulated by co-chaperone binding

(2018) Filip Trcka et al.   MOLECULAR & CELLULAR PROTEOMICS

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

Subzero Celsius separations in three-zone temperature controlled hydrogen deuterium exchange mass spectrometry

(2017) Thomas E. Wales et al.   JOURNAL OF CHROMATOGRAPHY A

Piecing Together the Allosteric Patterns of Chaperonin GroEL

(2017) Jin Chen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Mechanism of Enzyme Repair by the AAA + Chaperone Rubisco Activase

(2017) Javaid Y. Bhat et al.   MOLECULAR CELL

Protein folding by NMR

(2017) Anastasia Zhuravleva et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Protein Folding—How and Why: By Hydrogen Exchange, Fragment Separation, and Mass Spectrometry

(2016) S. Walter Englander et al.   Annual Review of Biophysics

Novel Entropically Driven Conformation-specific Interactions with Tomm34 Protein Modulate Hsp70 Protein Folding and ATPase Activities

(2016) Michal Durech et al.   MOLECULAR & CELLULAR PROTEOMICS

How cooperative are protein folding and unfolding transitions?

(2016) Pooja Malhotra et al.   PROTEIN SCIENCE

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

(2016) K. A. Verba et al.   SCIENCE

Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding

(2016) Sophia Ungelenk et al.   Nature Communications

Analytical Aspects of Hydrogen Exchange Mass Spectrometry

(2015) John R. Engen et al.   Annual Review of Analytical Chemistry

Continuous and Pulsed Hydrogen–Deuterium Exchange and Mass Spectrometry Characterize CsgE Oligomerization

(2015) Hanliu Wang et al.   BIOCHEMISTRY

Hsp90: Breaking the Symmetry

(2015) Matthias P. Mayer et al.   MOLECULAR CELL

Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation

(2015) Bei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90

(2015) Edgar E. Boczek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation

(2015) Bei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

(2014) Elaine Kirschke et al.   CELL

GroEL/ES Chaperonin Modulates the Mechanism and Accelerates the Rate of TIM-Barrel Domain Folding

(2014) Florian Georgescauld et al.   CELL

The Assembly and Intermolecular Properties of the Hsp70-Tomm34-Hsp90 Molecular Chaperone Complex

(2014) Filip Trcka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Unusual Dimeric Small Heat Shock Protein Provides Insight into the Mechanism of This Class of Chaperones

(2013) Eman Basha et al.   JOURNAL OF MOLECULAR BIOLOGY

An electrospray ms-coupled microfluidic device for sub-second hydrogen/deuterium exchange pulse-labelling reveals allosteric effects in enzyme inhibition

(2013) Tamanna Rob et al.   LAB ON A CHIP

Folding the proteome

(2013) Esther Braselmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nucleotide-induced conformational changes of tetradecameric GroEL mapped by H/D exchange monitored by FT-ICR mass spectrometry

(2013) Qian Zhang et al.   Scientific Reports

Dynamics of the regulation of Hsp90 by the co-chaperone Sti1

(2012) Chung-Tien Lee et al.   EMBO JOURNAL

DnaK Functions as a Central Hub in the E. coli Chaperone Network

(2012) Giulia Calloni et al.   Cell Reports

Insights into the Conformational Dynamics of the E3 Ubiquitin Ligase CHIP in Complex with Chaperones and E2 Enzymes

(2010) Christian Graf et al.   BIOCHEMISTRY

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Hydrogen/Deuterium Exchange Analysis of HIV-1 Capsid Assembly and Maturation

(2010) Eric B. Monroe et al.   STRUCTURE

Spatially and kinetically resolved changes in the conformational dynamics of the Hsp90 chaperone machine

(2009) Christian Graf et al.   EMBO JOURNAL

Insights into Small Heat Shock Protein and Substrate Structure during Chaperone Action Derived from Hydrogen/Deuterium Exchange and Mass Spectrometry

(2008) Guilong Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis for Regulation of the Heat Shock Transcription Factor σ32 by the DnaK and DnaJ Chaperones

(2008) Fernanda Rodriguez et al.   MOLECULAR CELL

Insights into the structural dynamics of the Hsp110-Hsp70 interaction reveal the mechanism for nucleotide exchange activity

(2008) C. Andreasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA