Insertion of a ligand to HER2 in gB retargets HSV tropism and obviates the need for activation of the other entry glycoproteins

To Infection and Beyond: The Multi-Pronged Anti-Cancer Mechanisms of Oncolytic Viruses

(2016) Kevin Cassady et al.   Viruses-Basel

Retargeting Strategies for Oncolytic Herpes Simplex Viruses

(2016) Gabriella Campadelli-Fiume et al.   Viruses-Basel

Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome

(2016) Gabriella Campadelli-Fiume et al.   Annual Review of Virology

A Functional Interaction between Herpes Simplex Virus 1 Glycoprotein gH/gL Domains I and II and gD Is Defined by Using Alphaherpesvirus gH and gL Chimeras

(2015) Qing Fan et al.   JOURNAL OF VIROLOGY

Dissociation of HSV gL from gH by αvβ6- or αvβ8-integrin promotes gH activation and virus entry

(2015) Tatiana Gianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Herpesvirus gB: A Finely Tuned Fusion Machine

(2015) Rebecca Cooper et al.   Viruses-Basel

Crystal Structure of the Human Cytomegalovirus Glycoprotein B

(2015) Heidi G. Burke et al.   PLoS Pathogens

The Engineering of a Novel Ligand in gH Confers to HSV an Expanded Tropism Independent of gD Activation by Its Receptors

(2015) Valentina Gatta et al.   PLoS Pathogens

Pediatric cancer gone viral. Part I: strategies for utilizing oncolytic herpes simplex virus-1 in children

(2015) Timothy P Cripe et al.   Molecular Therapy-Oncolytics

Nonmuscle Myosin Heavy Chain IIB Mediates Herpes Simplex Virus 1 Entry

(2014) Jun Arii et al.   JOURNAL OF VIROLOGY

Regulation of Herpes Simplex Virus gB-Induced Cell-Cell Fusion by Mutant Forms of gH/gL in the Absence of gD and Cellular Receptors

(2013) D. Atanasiu et al.   mBio

Preclinical Therapy of Disseminated HER-2+ Ovarian and Breast Carcinomas with a HER-2-Retargeted Oncolytic Herpesvirus

(2013) Patrizia Nanni et al.   PLoS Pathogens

αvβ6- and αvβ8-Integrins Serve As Interchangeable Receptors for HSV gH/gL to Promote Endocytosis and Activation of Membrane Fusion

(2013) Tatiana Gianni et al.   PLoS Pathogens

Novel Mutations in gB and gH Circumvent the Requirement for Known gD Receptors in Herpes Simplex Virus 1 Entry and Cell-to-Cell Spread

(2012) Hiroaki Uchida et al.   JOURNAL OF VIROLOGY

Oncolytic virotherapy

(2012) Stephen J Russell et al.   NATURE BIOTECHNOLOGY

Herpes Virus Fusion and Entry: A Story with Many Characters

(2012) Roselyn J. Eisenberg et al.   Viruses-Basel

Viral and cellular contributions to herpes simplex virus entry into the cell

(2012) Gabriella Campadelli-Fiume et al.   Current Opinion in Virology

 V 3-Integrin Relocalizes nectin1 and Routes Herpes Simplex Virus to Lipid Rafts

(2011) T. Gianni et al.   JOURNAL OF VIROLOGY

Fusing structure and function: a structural view of the herpesvirus entry machinery

(2011) Sarah A. Connolly et al.   NATURE REVIEWS MICROBIOLOGY

Structure of Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor Nectin-1

(2011) Paolo Di Giovine et al.   PLoS Pathogens

A Double Mutation in Glycoprotein gB Compensates for Ineffective gD-Dependent Initiation of Herpes Simplex Virus Type 1 Infection

(2010) H. Uchida et al.   JOURNAL OF VIROLOGY

Bimolecular Complementation Defines Functional Regions of Herpes Simplex Virus gB That Are Involved with gH/gL as a Necessary Step Leading to Cell Fusion

(2010) D. Atanasiu et al.   JOURNAL OF VIROLOGY

Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1

(2010) Jun Arii et al.   NATURE

Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL

(2010) Tirumala K Chowdary et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex

(2010) H. Matsuura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 V 3-integrin routes herpes simplex virus to an entry pathway dependent on cholesterol-rich lipid rafts and dynamin2

(2010) T. Gianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody

(2010) M. Backovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain

(2009) Tatiana Gianni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross Talk among the Glycoproteins Involved in Herpes Simplex Virus Entry and Fusion: the Interaction between gB and gH/gL Does Not Necessarily Require gD

(2009) E. Avitabile et al.   JOURNAL OF VIROLOGY

Inhibition of human tumor growth in mice by an oncolytic herpes simplex virus designed to target solely HER-2-positive cells

(2009) L. Menotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses

(2009) T. Suenaga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a trimeric variant of the Epstein–Barr virus glycoprotein B

(2009) Marija Backovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PILRα Is a Herpes Simplex Virus-1 Entry Coreceptor That Associates with Glycoprotein B

(2008) Takeshi Satoh et al.   CELL

Construction of a Fully Retargeted Herpes Simplex Virus 1 Recombinant Capable of Entering Cells Solely via Human Epidermal Growth Factor Receptor 2

(2008) L. Menotti et al.   JOURNAL OF VIROLOGY

Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded

(2008) Roberto Cattaneo et al.   NATURE REVIEWS MICROBIOLOGY