Article
Cell Biology
Minle Li, Xue Zhao, Hongmei Yong, Jian Xu, Pengfei Qu, Shuxi Qiao, Pingfu Hou, Zhongwei Li, Sufang Chu, Junnian Zheng, Jin Bai
Summary: Transketolase (TKT), an important enzyme in the pentose phosphate pathway, plays a crucial role in maintaining ribose 5-phosphate levels and cell growth. Recent studies have shown that TKT is not only involved in liver cancer development but also in colorectal cancer progression. Abnormal upregulation of TKT expression is associated with poor prognosis in colorectal cancer, and TKT promotes colorectal cancer cell growth and metastasis by enhancing glycolysis through AKT phosphorylation.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Chen Chen, Yang Liu, Lin Liu, Chaohua Si, Yanxin Xu, Xiaoke Wu, Chengzeng Wang, Zhenqiang Sun, Qiaozhen Kang
Summary: This study found that exosomes derived from colorectal cancer cells carry circTUBGCP4, which induces tip cell formation in vascular endothelial cells, promoting angiogenesis and tumor metastasis through the activation of the Akt signaling pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Liqun Yang, Zhigang Dong, Shuyu Li, Tieliang Chen
Summary: This study aimed to explore the influence of endothelial cell-specific molecule 1 (ESM1) expression on colorectal cancer (CRC) cells and analyze its possible mechanism. ESM1 overexpression was found to promote tumor angiogenesis in CRC and accelerate tumor progression. The study also revealed that ESM1 may promote angiogenesis in CRC by activating the PI3K/Akt/mTOR pathway.
Editorial Material
Medicine, General & Internal
Oladapo O. Yeku, Dan L. Longo
Summary: This editorial discusses the scientific basis of a clinical trial conducted by Prager and colleagues, which tested the efficacy of trifluridine-tipiracil and bevacizumab in treating patients with refractory metastatic colorectal cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Editorial Material
Oncology
Aaron M. Hosios, Brendan D. Manning
Summary: Research has deepened the understanding of oncogenic control of metabolism, particularly glycolysis. Current focus is on understanding the benefits and risks associated with glycolytic metabolism, and finding inhibitors that could be clinically beneficial for targeting glycolytic cancer cells.
Article
Cell Biology
Jihui Zheng, Wenjing Zhu, Fang He, Zhu Li, Na Cai, Hong-Hui Wang
Summary: Tumor angiogenesis is crucial in colorectal cancer development, and dysregulation of the receptor for the advanced glycation end-products (RAGE) signaling mediates inflammation leading to various cancers. This study revealed that an aptamer-based RAGE antagonist (Apt-RAGE) effectively inhibited RAGE/NF kappa B activation in colorectal cancer cells, decreasing proliferation and migration and inhibiting VEGF-A expression and secretion. The findings suggest that Apt-RAGE could be a potential therapeutic agent for colorectal cancer treatment through antiangiogenic effects.
MEDIATORS OF INFLAMMATION
(2021)
Article
Oncology
Qi Zhang, Changli Wang, Ruijia Li, Jingjing Liu, Jiyu Wang, Tianyi Wang, Bing Wang
Summary: BAP31 regulates colorectal cancer (CRC) angiogenesis by manipulating the tumor microenvironment. Exosomes from BAP31-overexpressing CRCs induce the transformation of normal fibroblasts into proangiogenic cancer-associated fibroblasts (CAFs). Moreover, miR-181a-5p, a microRNA present in the exosomes, directly targets the RECK gene and promotes endothelial cell angiogenesis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Mingxia Zhou, Jing He, Yingxia Li, Libin Jiang, Jiaxuan Ran, Chang Wang, Chenxi Ju, Dan Du, Xinyu Xu, Xuexin Wang, Hongle Li, Fucheng He, Hongtao Wen
Summary: REG1a is significantly increased in CRC tissues and serum, and positively associated with lymph node metastasis, advanced tumor stage, and unfavorable prognosis in CRC patients. REG1a regulates glycolysis via the ss-catenin/MYC axis, promoting CRC proliferation and metastasis. These findings suggest that REG1a could serve as a novel biomarker and potential therapeutic target for CRC.
CELL DEATH & DISEASE
(2023)
Editorial Material
Cell Biology
Hong Yan, Ronan Talty, Caroline H. Johnson
Summary: Ferroptosis has emerged as a promising target for colorectal cancer treatment, and besides disrupting glutathione metabolism, there are additional key pathways linking ferroptosis to CRC pathogenesis.
TRENDS IN CELL BIOLOGY
(2023)
Article
Oncology
Jinbiao Han, Xia Hu
Summary: This study found that the high expression of SIX4 is associated with low overall survival rates in ovarian cancer patients. Silencing SIX4 can inhibit proliferation, migration, invasion, and angiogenesis of ovarian cancer cells. Overexpression of IGF2BP3 improves the stability of SIX4 mRNA and reverses the inhibitory effect of SIX4 interference on ovarian cancer cell phenotypes.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Oncology
Shiki Fujino, Norikatsu Miyoshi, Aya Ito, Masayoshi Yasui, Masayuki Ohue, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Chu Matsuda, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi
Summary: The newly developed molecularly targeted therapy crenolanib shows potential as a treatment for colorectal cancer patients with KRAS and BRAF mutations by inhibiting cell growth, reducing stem cell marker expression, and exhibiting additive or synergistic effects when used in combination with other cytotoxic drugs. This suggests that crenolanib could be a useful targeted agent for colorectal cancer patients, particularly those with KRAS/BRAF mutations.
MOLECULAR CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Seung-hwan Jeong, Myung Jin Yang, Seunghyeok Choi, JungMo Kim, Gou Young Koh
Summary: STING agonists have been shown to induce early apoptosis of endothelial cells in subcutaneous xenografts models, while additional inhibition of AKT is required for efficient induction of apoptosis in primary tumors. This study proposes a more advanced avenue for treating primary tumors that are refractory to single STING agonist therapy.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Shin-Yi Chung, Ta-Chung Chao, Yeu Su
Summary: The study demonstrates that human CRCSCs with high GATA6 expression promote stronger angiogenesis by producing higher amounts of angiogenic factors through activation of the EGFR/AKT/NF-kappa B pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Hui Li, Bingxin Guan, Sen Liu, Haiting Liu, Lin Song, Guohao Zhang, Ruinan Zhao, Chengjun Zhou, Peng Gao
Summary: Gastric cancer is a highly heterogeneous disease with poor prognosis. Protein tyrosine phosphatases, specifically PTPN14, play a vital role in gastric cancer by promoting cell proliferation, migration, and invasion.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Hannah J. Wiedner, R. Eric Blue, Matheus Sadovsky, C. Allie Mills, Xander H. T. Wehrens, Laura E. Herring, Jimena Giudice
Summary: Alternative splicing is a prevalent gene-regulatory mechanism, and it plays a vital role in muscle cell differentiation by interacting with transcription factors SIX4 and ZBTB1 to control gene expression, and being regulated by splicing factor RBFOX2.