Targeting ferroptosis to treat colorectal cancer

Cancer statistics, 2022

(2022) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

(2022) Peng Liao et al.   CANCER CELL

A Dual PI3K/HDAC Inhibitor Induces Immunogenic Ferroptosis to Potentiate Cancer Immune Checkpoint Therapy

(2021) Fushun Fan et al.   CANCER RESEARCH

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

(2020) Xiaoguang Liu et al.   NATURE CELL BIOLOGY

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

(2020) Junmei Yi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis is a type of autophagy-dependent cell death

(2019) Borong Zhou et al.   SEMINARS IN CANCER BIOLOGY

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Erastin-Like Anti-Warburg Agents Prevent Mitochondrial Depolarization Induced by Free Tubulin and Decrease Lactate Formation in Cancer Cells

(2017) David N. DeHart et al.   SLAS Discovery