Repurposing benzbromarone for pulmonary arterial hypertension: can channelling the past deliver the therapy of the future?

Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic PAH

(2019) Rita Papp et al.   EUROPEAN RESPIRATORY JOURNAL

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

(2018) Stefan Gräf et al.   Nature Communications

Germline BMP9 mutation causes idiopathic pulmonary arterial hypertension

(2018) Xiao-Jian Wang et al.   EUROPEAN RESPIRATORY JOURNAL

Widening the landscape of heritable pulmonary hypertension mutations in pediatric and adult cases

(2018) Mélanie Eyries et al.   EUROPEAN RESPIRATORY JOURNAL

Repurposing Medications for Treatment of Pulmonary Arterial Hypertension: What's Old Is New Again

(2018) Kurt W. Prins et al.   Journal of the American Heart Association

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients

(2017) Evangelos D. Michelakis et al.   Science Translational Medicine

A burden of rare variants in BMPR2 and KCNK3 contributes to a risk of familial pulmonary arterial hypertension

(2017) Koichiro Higasa et al.   BMC Pulmonary Medicine

Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial HypertensionCLINICAL PERSPECTIVE

(2016) Fabrice Antigny et al.   CIRCULATION

A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells

(2015) Johanna Bertrand et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

(2015) Lu Long et al.   NATURE MEDICINE

Chloroquine Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Lysosomal Bone Morphogenetic Protein Type II Receptor Degradation

(2013) Lu Long et al.   CIRCULATION RESEARCH

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

(2013) Edda Spiekerkoetter et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel Channelopathy in Pulmonary Arterial Hypertension

(2013) Lijiang Ma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension

(2012) Abigail S. Forrest et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Chronic hypoxia-induced upregulation of Ca2+-activated Cl−channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity

(2012) Hui Sun et al.   JOURNAL OF PHYSIOLOGY-LONDON

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

(2012) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Functional Single-Nucleotide Polymorphism in the TRPC6 Gene Promoter Associated With Idiopathic Pulmonary Arterial Hypertension

(2009) Ying Yu et al.   CIRCULATION

A Benefit-Risk Assessment of Benzbromarone in the Treatment of Gout

(2009) Ming-Han H Lee et al.   DRUG SAFETY