Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement

Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins

(2015) Bo Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Synthesis and evaluation of 8,4′-dideshydroxy-leinamycin revealing new insights into the structure–activity relationship of the anticancer natural product leinamycin

(2015) Tao Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species

(2015) Sheng-Xiong Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C-S bond cleavage by a polyketide synthase domain

(2015) Ming Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improvement of Wuyiencin Biosynthesis in Streptomyces wuyiensis CK-15 by Identification of a Key Regulator, WysR

(2015) Yanyan Liu et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Comprehensive Computational Analysis of Bacterial CRP/FNR Superfamily and Its Target Motifs Reveals Stepwise Evolution of Transcriptional Networks

(2013) Motomu Matsui et al.   Genome Biology and Evolution

Molecular Regulation of Antibiotic Biosynthesis in Streptomyces

(2013) G. Liu et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0

(2013) Koichiro Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Analysis Tool Web Services from the EMBL-EBI

(2013) Hamish McWilliam et al.   NUCLEIC ACIDS RESEARCH

Noncovalent DNA Binding Drives DNA Alkylation by Leinamycin: Evidence That theZ,E-5-(Thiazol-4-yl)-penta-2,4-dienone Moiety of the Natural Product Serves as an Atypical DNA Intercalator

(2011) Mostafa I. Fekry et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation

(2010) Yihua Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY