Synthesis and evaluation of 8,4′-dideshydroxy-leinamycin revealing new insights into the structure–activity relationship of the anticancer natural product leinamycin

Title
Synthesis and evaluation of 8,4′-dideshydroxy-leinamycin revealing new insights into the structure–activity relationship of the anticancer natural product leinamycin
Authors
Keywords
Antitumor antibiotic, DNA alkylation, Leinamycin, Metabolic pathway engineering, Structure–activity relationship
Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 21, Pages 4899-4902
Publisher
Elsevier BV
Online
2015-05-30
DOI
10.1016/j.bmcl.2015.05.078

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