SOX2 is required for inner ear growth and cochlear nonsensory formation before sensory development

Chd7 Collaborates with Sox2 to Regulate Activation of Oligodendrocyte Precursor Cells after Spinal Cord Injury

(2017) Toru Doi et al.   JOURNAL OF NEUROSCIENCE

SOX2 is required for inner ear neurogenesis

(2017) Aleta R. Steevens et al.   Scientific Reports

Comprehensive profiling reveals mechanisms of SOX2-mediated cell fate specification in human ESCs and NPCs

(2016) Chenlin Zhou et al.   CELL RESEARCH

SOX2 is sequentially required for progenitor proliferation and lineage specification in the developing pituitary

(2016) Sam Goldsmith et al.   DEVELOPMENT

Lineage tracing of Sox2-expressing progenitor cells in the mouse inner ear reveals a broad contribution to non-sensory tissues and insights into the origin of the organ of Corti

(2016) Rende Gu et al.   DEVELOPMENTAL BIOLOGY

Dual role for Sox2 in specification of sensory competence and regulation of Atoh1 function

(2016) Chandrakala Puligilla et al.   Developmental Neurobiology

CHD7, Oct3/4, Sox2, and Nanog control FoxD3 expression during mouse neural crest-derived stem cell formation

(2016) Kyohei Fujita et al.   FEBS Journal

Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance

(2016) Martina Dvorakova et al.   Scientific Reports

Sox2 in the differentiation of cochlear progenitor cells

(2016) Judith S. Kempfle et al.   Scientific Reports

SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis

(2015) Alejandro Amador-Arjona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C-MYC Transcriptionally Amplifies SOX2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells

(2015) Kelvin Y. Kwan et al.   Stem Cell Reports

Sox2 Acts in a Dose-Dependent Fashion to Regulate Proliferation of Cortical Progenitors

(2014) Daniel W. Hagey et al.   Cell Reports

Opposing Regulation of Sox2 by Cell-Cycle Effectors E2f3a and E2f3b in Neural Stem Cells

(2013) Lisa M. Julian et al.   Cell Stem Cell

The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate

(2013) Abby Sarkar et al.   Cell Stem Cell

Sox proteins: regulators of cell fate specification and differentiation

(2013) Y. Kamachi et al.   DEVELOPMENT

Progression of Neurogenesis in the Inner Ear Requires Inhibition of Sox2 Transcription by Neurogenin1 and Neurod1

(2013) L. Evsen et al.   JOURNAL OF NEUROSCIENCE

Sox2 Expression Is Regulated by a Negative Feedback Loop in Embryonic Stem Cells That Involves AKT Signaling and FoxO1

(2013) Briana D. Ormsbee Golden et al.   PLoS One

SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors

(2013) F. Cimadamore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells

(2013) Jinwoong Bok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concise Review: The Sox2-Oct4 Connection: Critical Players in a Much Larger Interdependent Network Integrated at Multiple Levels

(2013) Angie Rizzino   STEM CELLS

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear

(2012) M. Ahmed et al.   DEVELOPMENT

Eya1-Six1 Interaction Is Sufficient to Induce Hair Cell Fate in the Cochlea by Activating Atoh1 Expression in Cooperation with Sox2

(2012) Mohi Ahmed et al.   DEVELOPMENTAL CELL

Sox2 regulation of hair cell development: incoherence makes sense

(2012) Joana Neves et al.   HEARING RESEARCH

Regulation of p27Kip1 by Sox2 Maintains Quiescence of Inner Pillar Cells in the Murine Auditory Sensory Epithelium

(2012) Z. Liu et al.   JOURNAL OF NEUROSCIENCE

The Prosensory Function of Sox2 in the Chicken Inner Ear Relies on the Direct Regulation of Atoh1

(2012) Joana Neves et al.   PLoS One

Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice

(2011) Katrin Arnold et al.   Cell Stem Cell

Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: a mechanism for sensory organ specification

(2011) J. Neves et al.   DEVELOPMENT

Shaping sound in space: the regulation of inner ear patterning

(2011) A. K. Groves et al.   DEVELOPMENT

Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear

(2011) Benjamin Kopecky et al.   DEVELOPMENTAL DYNAMICS

Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes

(2011) Erik Engelen et al.   NATURE GENETICS

The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear

(2010) E. A. Hurd et al.   DEVELOPMENT

Independent regulation of Sox3 and Lmx1b by FGF and BMP signaling influences the neurogenic and non-neurogenic domains in the chick otic placode

(2010) G. Abelló et al.   DEVELOPMENTAL BIOLOGY

Sox2 Induces Neuronal Formation in the Developing Mammalian Cochlea

(2010) C. Puligilla et al.   JOURNAL OF NEUROSCIENCE

Evidence That SOX2 Overexpression Is Oncogenic in the Lung

(2010) Yun Lu et al.   PLoS One

Pax6 is essential for lens fiber cell differentiation

(2009) O. Shaham et al.   DEVELOPMENT

Multiple roles for Sox2 in the developing and adult mouse trachea

(2009) J. Que et al.   DEVELOPMENT

SOX–partner code for cell specification: Regulatory target selection and underlying molecular mechanisms

(2009) Hisato Kondoh et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Impaired generation of mature neurons by neural stem cells from hypomorphic Sox2 mutants

(2008) M. Cavallaro et al.   DEVELOPMENT

Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea

(2008) A. Dabdoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA