Evidence That SOX2 Overexpression Is Oncogenic in the Lung

SOX2 Is an Oncogene Activated by Recurrent 3q26.3 Amplifications in Human Lung Squamous Cell Carcinomas

(2010) Thomas Hussenet et al.   PLoS One

Sex Determining Region Y-Box 2 (SOX2) Is a Potential Cell-Lineage Gene Highly Expressed in the Pathogenesis of Squamous Cell Carcinomas of the Lung

(2010) Ping Yuan et al.   PLoS One

The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium

(2009) Emma L. Rawlins et al.   Cell Stem Cell

Multiple roles for Sox2 in the developing and adult mouse trachea

(2009) J. Que et al.   DEVELOPMENT

Peripheral pulmonary papillary/glandular neoplasms with ciliated cells and a component of well-differentiated adenocarcinoma: report of three tumours

(2009) Yoshifumi Arai et al.   HISTOPATHOLOGY

An Active Role of the ΔN Isoform of p63 in Regulating Basal Keratin Genes K5 and K14 and Directing Epidermal Cell Fate

(2009) Rose-Anne Romano et al.   PLoS One

Sox2 Is Required for Maintenance and Differentiation of Bronchiolar Clara, Ciliated, and Goblet Cells

(2009) David H. Tompkins et al.   PLoS One

Basal cells as stem cells of the mouse trachea and human airway epithelium

(2009) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sox2 Expression in Pulmonary Non-small Cell and Neuroendocrine Carcinomas

(2009) Lynette M. Sholl et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Sox2 is important for two crucial processes in lung development: Branching morphogenesis and epithelial cell differentiation

(2008) Cristina Gontan et al.   DEVELOPMENTAL BIOLOGY

The Molecular Mechanism Governing the Oncogenic Potential of SOX2 in Breast Cancer

(2008) Yupeng Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

“Stemness” Genomics Law Governs Clinical Behavior of Human Cancer: Implications for Decision Making in Disease Management

(2008) Gennadi V. Glinsky   JOURNAL OF CLINICAL ONCOLOGY

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS