dl ‐3‐n‐butylphthalide preserves white matter integrity and alleviates cognitive impairment in mice with chronic cerebral hypoperfusion

Dl-3-n-Butylphthalide (NBP)：A Promising Therapeutic Agent for Ischemic Stroke

(2018) S Wang et al.   CNS & Neurological Disorders-Drug Targets

FasL incapacitation alleviates CD4 + T cells-induced brain injury through remodeling of microglia polarization in mouse ischemic stroke

(2018) Haoran Zhao et al.   JOURNAL OF NEUROIMMUNOLOGY

TRPM2 Channel Aggravates CNS Inflammation and Cognitive Impairment via Activation of Microglia in Chronic Cerebral Hypoperfusion

(2018) Jun Miyanohara et al.   JOURNAL OF NEUROSCIENCE

DL-3-n-butylphthalide alleviates vascular cognitive impairment induced by chronic cerebral hypoperfusion by activating the Akt/Nrf2 signaling pathway in the hippocampus of rats

(2018) Qianqian Qi et al.   NEUROSCIENCE LETTERS

Long-Term DL-3-n-Butylphthalide Treatment Alleviates Cognitive Impairment Correlate With Improving Synaptic Plasticity in SAMP8 Mice

(2018) Chaonan Lv et al.   Frontiers in Aging Neuroscience

Variability of functional outcome measures used in animal models of stroke and vascular cognitive impairment – a review of contemporary studies

(2018) Tuuli M Hietamies et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A new era for stroke therapy: Integrating neurovascular protection with optimal reperfusion

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From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives

(2018) Longjian Huang et al.   PHARMACOLOGICAL RESEARCH

Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study

(2018) Jing‐Wen Yang et al.   CNS Neuroscience & Therapeutics

Oxygen-Glucose Deprivation in Mouse Astrocytes is Associated with Ultrastructural Changes in Connexin 43 Gap Junctions

(2018) Anja Beckmann et al.   NEUROSCIENCE

PSD-93 Attenuates Amyloid-β-Mediated Cognitive Dysfunction by Promoting the Catabolism of Amyloid-β

(2017) Linjie Yu et al.   JOURNAL OF ALZHEIMERS DISEASE

White matter hyperintensities associated with small vessel disease impair social cognition beside attention and memory

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The effects of environmental enrichment on white matter pathology in a mouse model of chronic cerebral hypoperfusion

(2017) Yoshiki Hase et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

DL-3-n-butylphthalide protects endothelial cells against advanced glycation end product-induced injury by attenuating oxidative stress and inflammation responses

(2017) Chang-Yun Liu et al.   Experimental and Therapeutic Medicine

Dl-3-n-Butylphthalide Treatment Enhances Hemodynamics and Ameliorates Memory Deficits in Rats with Chronic Cerebral Hypoperfusion

(2017) Zhilin Xiong et al.   Frontiers in Aging Neuroscience

Soluble epoxide hydrolase inhibition Promotes White Matter Integrity and Long-Term Functional Recovery after chronic hypoperfusion in mice

(2017) Yuxue Chen et al.   Scientific Reports

The effects of DL-3-n-butylphthalide in patients with vascular cognitive impairment without dementia caused by subcortical ischemic small vessel disease: A multicentre, randomized, double-blind, placebo-controlled trial

(2016) Jianping Jia et al.   Alzheimers & Dementia

Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions

(2016) Ying Yang et al.   NEUROCHEMISTRY INTERNATIONAL

Rodent Models of Vascular Cognitive Impairment

(2016) Yi Yang et al.   Translational Stroke Research

A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives

(2016) Idriss Ali Abdoulaye et al.   Biomed Research International

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

(2016) Raman Saggu et al.   Acta Neuropathologica Communications

Ecto-5′-nucleotidase (CD73) is involved in chronic cerebral hypoperfusion-induced white matter lesions and cognitive impairment by regulating glial cell activation and pro-inflammatory cytokines

(2015) X. Hou et al.   NEUROSCIENCE

The Effect of Butylphthalide on the Brain Edema, Blood–Brain Barrier of Rats After Focal Cerebral Infarction and the Expression of Rho A

(2014) Jinyang Hu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Apoptosis Signal–Regulating Kinase 1 Is a Novel Target Molecule for Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion

(2013) Kensuke Toyama et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

3-N-Butylphthalide (NBP) Attenuates the Amyloid-�-Induced Inflammatory Responses in Cultured Astrocytes via the Nuclear Factor-κB Signaling Pathway

(2013) Hong-Mei Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Therapeutic Effect of DL-3-n-Butylphthalide in Rats with Chronic Cerebral Hypoperfusion through Downregulation of Amyloid Precursor Protein and Matrix Metalloproteinase-2

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The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

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Matrix Metalloproteinases Are Associated With Increased Blood–Brain Barrier Opening in Vascular Cognitive Impairment

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Inflammation and the neurovascular unit in the setting of focal cerebral ischemia

(2008) G.J. del Zoppo   NEUROSCIENCE

Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia

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